Charles Keller Lab
The Keller Laboratory studies the driving mechanisms and therapeutic targets in the childhood muscle cancers, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma, and the childhood brain tumor, medulloblastoma.
Latest from the Keller Lab Blog
The Community takes the leadAn exciting initiative from families of rhabdomyosarcoma patients has begun at http://focusonrhabdo.org/. The group has the goal of making rhabdomyosarcoma a uniformly survivable disease with an improved quality of life. A great number of rhabdomyosarcoma researchers will provide support to this group, but the goals and mission are being set those who may know the disease best, the families.
Congratulations, Ken!Ken's recent paper on a fascinating and clinically-relevant aspect of alveolar rhabdomyosarcoma biology has just been accepted to PLoS Genetics. Co-authors included lab alumnist Imran Aslam (now a medicine resident at Johns Hopkins), OHSU collaborator Wolfram Laub, UTHSCSA collaborator Joel Michalek, Harvard collaborators Simone Hettmer and Amy Wagers, JHMI collaborators David Loeb and Bree Wilky and Cleveland Clinic collaborator Brian Rubin.
This is Ken's 8th paper (and 6th first author paper) from his 2 year postdoctoral fellowship in our lab (with one additional first author manuscript soon to be submitted). Amazing productivity for Ken, who is now faculty at Uji Takeda Hospital and Kyoto Prefectural University.
The study above was made possible by funding from the NCI.
Congratulations, Ken and Eri!Eri & Ken's co-first author study of the role of the retinoblastoma gene in rhabdomyosarcoma has been accepted to the journal, Skeletal Muscle. Co-authors include lab members Noah, Jinu and Matthew; lab alumni Olivia, Elaine and Koichi; as well as collaborators Ayeza & Atiya (OHSU Pathology), Sherrie (Univ of Utah), Paul & Sean (NCI), Harry, Lee Ann Chris, Yidong and Joel (UTHSCSA), Brian (Cleveland Clinic) and Monica (IMPPC, Barcelona).
[update 11/25/2013: the manuscript Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma is now available online here.]