Charles Keller Lab

Charles Keller Lab


The Keller Laboratory studies the driving mechanisms and therapeutic targets in the childhood muscle cancers, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma, and the childhood brain tumor, medulloblastoma.

Latest from the Keller Lab Blog

Be a Dog's Best Friend

Can finding new treatments for dogs with soft tissue sarcomas also help develop new drugs for children and adults with soft tissue sarcomas?  This possibility is raised by today's publication by collaborator Milan Milovance entitled, Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcoma.  Co-authors of this study include Charles, as well as long time collaborator adult sarcoma pathologist, Atiya Mansoor.  [ pictured: undifferentiated sarcoma (also called UPS, or MFH) in dog and human ]  

The Art of Survivorship

This month the collection, "Mother & Son: The Art of a Mom’s Journey through Childhood Cancer with Her Son" will be on display at Tiny’s Coffee 1412 SE 12th Portland, Oregon.  The artist, April, is an advocate for childhood cancer survivorship, her son now thriving after a challenging period with sarcoma.  The mixed media of paint-on-radiograph is accompanied by the history, from a mother's perspective, of the experience.  


AACR Pediatric Cancer Think-Tank

This week the AACR held a think-tank in Philadelphia on the critical issues in childhood cancer research and care delivery.   In attendance were 43 invitees from universities, pharmaceutical companies and patient advocacy groups.  Topics included prevention (yes, prevention!), improved care for hereditable cancer predispositions, making drugs available for children with cancer, and the promise of genomics in delivering personalized cancer care.  Charles presented on the topic that not only mutation but also cell of origin strongy influences response to treatment - and the types of epigenetic therapies that can be given.