Kris Weymann, Ph.D., R.N.
Oregon Health & Science University
School of Nursing Portland Campus
3455 SW US Veterans Hospital Rd.
Portland, Ore. 97239-2941
I am interested in understanding mechanisms of disrupted sleep and wakefulness associated with illness and injury, and the effects of these disruptions on recovery. My experiences as a nurse working with people following brain injury from stroke, trauma, and cancer who had persistent difficulties with fatigue, disrupted wakefulness, and disrupted sleep drive my interest to develop targeted therapies for these symptoms. I found that cytotoxic chemotherapy disrupts orexin neuropeptide signaling in the brain. This disruption was associated with decreased wakefulness and activity in rodents. I am currently examining how long orexin signaling is impaired after chemotherapy treatment. I also conduct clinical research on sleep disordersin Veterans. My long term research goal is to improve recovery from brain injury by targeting sleep and wakefulness.
BS - Biology - University of California-Davis
BSN - Oregon Health & Science University
MS - North Carolina State University
PhD - Nursing - Oregon Health & Science University
NIH-NINR - summer genetics institute
Pathophysiology I and II (NRS 232, 233)
Pharmacology I and II (NRS230, 231)
Integrated Clinical Practicum (NRS 424, 425)
Weymann, K.B., Wood, L.J., Zhu, X., & Marks, D.L. (2014). A role for orexin in cytotoxic chemotherapy-induced fatigue. Brain, Behavior, and Immunity, 37, 84-94. PMID: 24216337.
Wood, L.J. & Weymann, K. (2013). Inflammation and neural signaling: etiologic mechanisms of the cancer treatment-related symptom cluster. Current Opinion in Supportive & Palliative Care. 7, 54-59 PMID: 23314015.
Smith, L.B., Leo, M.C., Anderson, C., Wright, .TJ., Weymann, K.B., & Wood, L.J. (2014). The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS): A study using cytokine receptor-deficient mice. Brain, Behavior, and Immunity. in press. doi: 10.1016/j.bbi.2013.12.022. PMID: 24412646.