Christopher S. Lee, Ph.D., R.N., F.A.H.A., F.A.A.N., F.H.F.S.A.

Christopher Lee
Carol A. Lindeman Distinguished Professor & Associate Professor
Assistant PhD Program Director
Oregon Health & Science University
School of Nursing Portland Campus
3455 SW US Veterans Hospital Road, SN-6N
Portland, Ore. 97239
Phone: 503 494-4410
Fax: 503 494-4456

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My main research interest involves “biobehavioral profiling” of adults with chronic cardiovascular disease in general and with advanced heart failure in particular. This innovative research process, informed by extensive interdisciplinary training and collaboration, employs advanced statistical techniques to mine heterogeneous responses to heart failure and identify patient subgroups that are particularly vulnerable to poor clinical outcomes and quality-of-life. My prior research (1F31NR010299) has informed how favorable self-care behaviors are associated with better intermediary (biomarkers of systemic inflammation and myocardial stress, and intra-thoracic impedance parameters), humanistic (health status), economic (direct inpatient cost), and clinical outcomes (event-free survival). My current clinical research focuses on characterizing gender differences in physical and psychological symptom profiles (K12HD043488), identifying favorable patterns of self-care behaviors over time among adults with heart failure (11BGIA7840062), and identifying common and distinct trajectories of change in symptoms and pathogenic biomarkers in heart failure patients undergoing the advanced therapy of mechanical circulatory support (1R01NR013492). Unexplained heterogeneity in response to heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education and anticipatory guidance, and personalize monitoring and management strategies. Findings from my past, current, and planned research will lead seamlessly to the development of a new breed of interventions in heart failure that are tailored to observed biobehavioral profiles.


2010    Post-Doctoral Fellowship, University of Arizona College of Pharmacy
2009    PhD, Nursing, Univ. of Pennsylvania School of Nursing
2005    MSN, Adult Acute Care, University of Pennsylvania School of Nursing
1996    BSN, Nursing, University of New Hampshire School of Nursing


NURS 629 Analysis Methods for Quantitative Research: Applied Statistics II


NIH/NINR 1R01NR013492; (Lee): OHSU School of Nursing; (Lee/Lyons): IN-STEP OHSU Hartford Center; (Lee): ASCENSION OHSU Alumni Association; (Lee): ORION NIH/NINR F31NR015195; (Miller): NIH/NINR F31NR014760; (Bidwell):

Funded Research

NIH/NINR 1R01NR013492;PI, (PI: Lee).
NIH/NINR R01NR016017;Co-I, (PI: Hansen).
NIH/NHLBI R01HL130502;Site-PI, (PI: Grady).
NIH/NINR F31NR015195;Sponsor, (PI: Miller).
NIH/NINR F31NR014760;Sponsor (PI: Bidwell)
NIH/NINR F31NR015936;Sponsor (PI: Denfeld).
NIH/ORWH K12HD043488;Sponsor (PI: Tilden).

Service activities

Interdisciplinary Advocacy Committee, HFSA
American Academy of Nursing Institute for Nursing Leadership, Advisory Board Member
National Institutes of Health Nursing and Related Clinical Sciences Standing Study Section

Selected Publications

Lee, C.S., Hiatt, S.O., Denfeld, Q.E., Mudd, J.O., Chien, C.V., Gelow, G.M. Symptom-hemodynamic mismatch and heart failure event risk (2015). Journal of Cardiovascular Nursing. 30(5):394-402. PMCID: PMC4281513.

Lee, C.S., Vellone, E. Lyons, K.S., Cocchieri, A., Bidwell, J.T., D'Agostino, F., Hiatt, S.O., Alvaro, R., Buck, H.G., Riegel, B. Patterns and predictors of patient and caregiver engagement in heart failure care: a multi-level dyadic study (2015). International Journal of Nursing Studies. 52(2):588-597 (PMID: 25468283).

Lee, C.S., Gelow, J.M., Denfeld, Q.E., Mudd, J.O., Burgess, D., Green, J.K., Hiatt, S. O., Jurgens, C.Y. Physical and psychological symptom profiling and event-free survival in adults with moderate to advanced heart failure (2014). Journal of Cardiovascular Nursing. 29(4), 315-323;(PMCID: PMC3762955).

Lee, C.S., Mudd, J.O., Hiatt, S.O., Gelow, J.M., Chien, C.V., Riegel, B. Trajectories of heart failure self-care management and changes in quality of life (2015). European Journal of Cardiovascular Nursing. 14(6):486-94. PMID: 24982435).

Lee, C.S., Chien, C.V., Bidwell, J.T., Gelow, J.M., Denfeld, Q.E., Masterson Creber, R., Buck, H.G., Mudd, J.O. Comorbidity profiles and inpatient outcomes during hospitalization for heart failure: an analysis of the U.S. nationwide inpatient sample (2014). BMC Cardiovascular Disorders. 14:73 (PMCID: PMC4057902).

Lee, C. S., Greenberg, B. H., Laramee, A. S., Ammon, S. E., Prasun, M., Galvao, M., Doering, L. V., Sherman, M. E., Stevenson, L. W., Gregory, D. D., Heidenreich, P. A., Kapur, N. K., O'Connell, J. B., Taylor, A. L., Hill, J. A., Baas, L., Gibbs, A., Rasmusson, K., Lewis, C., Kirkwood, P., Reigle, J., Rathman, L.,Bither, C. HFSA and AAHFN Joint Position Statement: Advocating for a Full Scope of Nursing Practice and Leadership in Heart Failure. Journal of Cardiac Failure (2012). 18(11):811-2 (PMID: 23141852).