Christopher S. Lee, Ph.D., R.N., F.A.H.A.

Christopher Lee
Associate Professor
Oregon Health & Science University
School of Nursing Portland Campus
3455 SW US Veterans Hospital Road, SN-6N
Portland, Ore. 97239
Phone: 503 494-4410
Fax: 503 494-4456

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My main research interest involves “biobehavioral profiling” of adults with chronic cardiovascular disease in general and with advanced heart failure in particular. This innovative research process, informed by extensive interdisciplinary training and collaboration, employs advanced statistical techniques to mine heterogeneous responses to heart failure and identify patient subgroups that are particularly vulnerable to poor clinical outcomes and quality-of-life. My prior research (1F31NR010299) has informed how favorable self-care behaviors are associated with better intermediary (biomarkers of systemic inflammation and myocardial stress, and intra-thoracic impedance parameters), humanistic (health status), economic (direct inpatient cost), and clinical outcomes (event-free survival). My current clinical research focuses on characterizing gender differences in physical and psychological symptom profiles (K12HD043488), identifying favorable patterns of self-care behaviors over time among adults with heart failure (11BGIA7840062), and identifying common and distinct trajectories of change in symptoms and pathogenic biomarkers in heart failure patients undergoing the advanced therapy of mechanical circulatory support (1R01NR013492). Unexplained heterogeneity in response to heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education and anticipatory guidance, and personalize monitoring and management strategies. Findings from my past, current, and planned research will lead seamlessly to the development of a new breed of interventions in heart failure that are tailored to observed biobehavioral profiles.


2010    Post-Doctoral Fellowship, University of Arizona College of Pharmacy
2009    PhD, Nursing, Univ. of Pennsylvania School of Nursing
2005    MSN, Adult Acute Care, University of Pennsylvania School of Nursing
1996    BSN, Nursing, University of New Hampshire School of Nursing


NURS 631 Nursing Science Focus Area
NURS 629 Analysis Methods for Quantitative Research: Applied Statistics II

Funded Research

NIH/ORWH K12HD043488; (Lee); 7/2010-6/2012.

American Heart 11BGIA7840062; (Lee); 7/2011-6/2013.

NIH/NINR 1R01NR013492; (Lee); 4/2012-3/2016.

Service activities

Chair, Early Career Committee, CVN Council, AHA

Scientific Review Group, Outcomes & Qualitative Research – Therapeutic Clinical Trials, AHA

Interdisciplinary Advocacy Committee, HFSA

Research Council and PhD Admission and Progression, OHSU SON

Selected Publications

Lee, C.S., Lyons, K.S., Gelow, J.M., Mudd, J.O., Hiatt, S.O., Nguyen, T. Jaarsma T. Validity and reliability of the european heart failure self-care behavior scale among U.S. adults with symptomatic heart failure. European Journal of Cardiovascular Nursing (In Press).

Lee, C.S., Gelow, J.M., Bidwell, J.T., Mudd, J.O., Green, J.K, Jurgens, C.Y., Woodruff-Pak, D.S. Blunted responses to heart failure symptoms in adults with mild cognitive dysfunction. Journal of Cardiovascular Nursing (In Press).

Lee, C.S., Greenberg, B.H., Laramee, A.S., Ammon, S.E., Prasun, M., PhD, Galvao, M., et al. (2012) HFSA and AAHFN Joint Position Statement: Advocating for a Full Scope of Nursing Practice and Leadership in Heart Failure. Journal of Cardiac Failure 18(11):811-2 published simultaneously in Heart & Lung, 41(6), 531-533.

Riegel, B., Lee, C.S., Ratcliffe, S.J., De Geest, S., Potashnik, S., Patey, M., Sayers, S.L., Goldberg, L.R., Weintraub, W.S. (2012) Predictors of objectively measured medication nonadherence in adults with heart failure. Circulation: Heart Failure, (In Press).

Lee, C.S., Moser, D.K., Lennie, T.A., Tkacs, N.C., Margulies, K.B., Riegel, B. (2011). Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management. Journal of Cardiovascular Nursing, 26(4), 321-328.

Riegel, B., Lee, C.S., Dickson, V.V. (2011). Self-care in patients with chronic heart failure: Predictors, outcomes, public-health and policy implications. Nature Reviews Cardiology, 8(11):644-654.

Lee, C.S., Moser, D.K., Lennie, T.A. & Riegel, B. (2011). Event-free survival in adults with heart failure who engage in self-care management. Heart & Lung, 40(1), 12-20.

Lee, C.S., Riegel, B., Driscoll, A., Suwanno, J., Moser, D.K., Lennie, T.A., Dickson, V.V., Cameron, J. & Worral-Carter, L. (2009). Gender differences in heart failure self-care: a multinational cross-sectional study. International Journal of Nursing Studies, 46(11), 1485–149.

Lee, C.S., Tkacs, N., & Riegel, B. (2009). The influence of heart failure self-care on health outcomes: hypothetical cardioprotective mechanisms. Journal of Cardiovascular Nursing, 24(3), 179-189.

Riegel, B., Moser, D.K., Anker, D.K., Appel, L.J., Dunbar, S.B., Grady, K.L., Gurvitz, M., Havranek, E.P., Lee, C.S., Lindenfeld, J., Peterson, P., Pressler, S.J., Schocken, D.D., Whellan, D. (2009). State of the science: Promoting self-care in persons with heart failure: Scientific Statement of the American Heart Association. Circulation, 120, 1141-1163.