Christopher Sean Lee, Ph.D., R.N.
Oregon Health & Science University
School of Nursing Portland Campus
3455 SW US Veterans Hospital Road, SN-6N
Portland, Ore. 97239
Phone: 503 494-4410
Fax: 503 494-4456
E-mail: leechri@ohsu.edu
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My main research interest involves “biobehavioral profiling” of adults with chronic cardiovascular disease in general and with heart failure in particular. This innovative research process, informed by extensive interdisciplinary training and collaboration, employs advanced statistical techniques to mine heterogeneous responses to heart failure and identify patient subgroups that are particularly vulnerable to poor clinical outcomes and quality-of-life. My prior research (1F31NR010299) has informed how favorable self-care behaviors are associated with better intermediary (biomarkers of systemic inflammation and myocardial stress, and intra-thoracic impedance parameters), humanistic (health status), economic (direct inpatient cost), and clinical outcomes (event-free survival). My current clinical research focuses on characterizing gender differences in physical and psychological symptom profiles (K12HD043488), and on identifying favorable patterns of self-care behaviors over time among adults with heart failure (11BGIA7840062). Continuing this line of clinical inquiry, my pending research involves using technology from implanted therapeutic devices to characterizing distinct patterns of symptom recognition delays (1R21NR013234-pending), and identifying common and distinct trajectories of change in symptoms and pathogenic biomarkers in heart failure patients undergoing the advanced therapy of mechanical circulatory support (1R01NR013492-pending). Unexplained heterogeneity in response to heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education and anticipatory guidance, and personalize monitoring and management strategies. Findings from my past, current, and planned research will lead seamlessly to the development of a new breed of interventions in heart failure that are tailored to observed biobehavioral profiles.
Education
2010 Post-Doctoral Fellowship, University of Arizona College of Pharmacy2009 PhD, Nursing, Univ. of Pennsylvania School of Nursing
2005 MSN, Adult Acute Care, University of Pennsylvania School of Nursing
1996 BSN, Nursing, University of New Hampshire School of Nursing
Funded Research
Funded Research: NIH/ORWH K12 HD043488; (Lee); 7/2010-6/2012. Gender-differences in symptoms of heart failure.American Heart 11BGIA7840062; (Lee); 7/2011-6/2013. Patterns of symptom management behaviors in heart failure.
Service activities
AHA, Founder and Co-Chair, Early Career Committee, CV Nursing CouncilAHA, Outcomes & Qualitative Research – Therapeutic Clinical Trials Grant SRG
HFSA, Interdisciplinary Advocacy Committee
OHSU SON Research Council
OHSU Hospital Nursing Research Council
Selected Publications
Lee, C.S., Moser, D.K., Lennie, T.A., Tkacs, N.C., Margulies, K.B., Riegel, B. Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management. Journal of Cardiovascular Nursing, 2011, 26(4); 321-328 PMCID: PMC3114259).
Lee, C.S., Moser, D.K., Lennie, T.A. & Riegel, B. Event-free survival in adults with heart failure who engage in self-care management. Heart & Lung, 2011, 40(1); 12-20 (PMCID: PMC2943989).
Riegel, B., Lee, C.S., Chung, M., Albert, N., Lennie, T.A., Song, E.K., Bentley, B., Worral-Carter, L., Heo, S., Moser, D.K. From novice to expert: confidence and activity status determine heart failure self-care performance. Nursing Research 2011; 60(2): 132-8 (PMID: 21317825).
Buck, H.G., Lee, C.S., Moser, D.K., Albert, N., Lennie, T., Bentley, B., Worrall-Carter, L., Riegel, B. The relationship between self-care and health related quality of life in older adults with moderate to advanced heart failure. Journal of Cardiovascular Nursing (In Press) (PMID: 21558868).
Riegel, B., Lee, C.S., Dickson, V.V. Self-care in patients with chronic heart failure: predictors, outcomes, public-health and policy implications. Nature Reviews Cardiology. 2011, Epub ahead of print (PMID: 21769111).
Lee, C.S., Riegel, B., Driscoll, A., Suwanno, J., Moser, D.K., Lennie, T.A., Dickson, V.V., Cameron, J. & Worral-Carter, L. Gender differences in heart failure self-care: a multinational cross-sectional study. International Journal of Nursing Studies 2009; 46(11), 1485–1495 (PMCID: PMC2743780).
Lee, C.S., Suwanno, J., Riegel, B. The relationship between self-care and health status domains in Thai patients with heart failure. European Journal of Cardiovascular Nursing 2009; 8(4), 259–266 (PMCID: PMC2757500).
Riegel, B., Moser, D.K., Anker, D.K., Appel, L.J., Dunbar, S.B., Grady, K.L., Gurvitz, M., Havranek, E.P., Lee, C.S., Lindenfeld, J., Peterson, P., Pressler, S.J., Schocken, D.D., Whellan, D. State of the science: promoting self-care in persons with heart failure: Scientific Statement of the American Heart Association. Circulation 2009; 120, 1141-1163 (PMID: 19720935).
Lee, C.S., Tkacs, N., & Riegel, B. The influence of heart failure self-care on health outcomes: hypothetical cardioprotective mechanisms. Journal of Cardiovascular Nursing 2009; 24(3,) 179-189 (PMID: 19279494).
Lee, C.S. & Tkacs, N. Current concepts of neurohormonal activation in heart failure: mediators and mechanisms. AACN Advanced Critical Care 2008; 19(4), 364-385 (PMID: 18981739).
