OHSU

TEG & TBI Progression

Thrombelastography Identifies Differences in Coagulation in Brain Injured Patients with and without Progression of Intracranial Hemorrhage

Principal Investigator: Susan Rowell, MD

What is the TEG &TBI Progression study?

Thrombelastography (TEG) is a different type of test that tells us many details about how blood clots. The purpose of this study is to find out if TEG is better than our current blood tests at predicting which patients with bleeding in the brain will get worse and which patients will not get worse.

Why do this study?

Whole blood is made up of four main parts that can be separated out: red blood cells, white blood cells, plasma, and platelets. TEG is different than traditional tests because it uses all parts of the blood (whole blood) to measure how well the blood clots and if the clotting changes after the traumatic brain injury. We will compare and analyze the TEG results with the standard coagulation tests. We want to see if the TEG is more sensitive and better able to predict worsening of brain injury on CT exams, the need for neurosurgical procedures, and mortality of patients.

Who will be included?

Any trauma patient admitted through the OHSU Emergency Department (ED) with a closed head injury and confirmed head bleed shown on a CT scan.

What is involved?

Each patient will have 5 small blood draws with each blood draw being about 1.5 teaspoons. The blood draws begin when the patient arrives in the ED, then at 6 hours, 12 hours, 24 hours, and 48 hours after arrival to the ED. We will review the medical record for medications, age, sex, height, weight, certain blood tests, vital signs, procedures or operations, complications and the amount of time the subject is in the hospital. We will also collect information about how the injury happened and transport to the hospital. We are collecting this data because we do not know if there are other reasons that could play a role in the blood’s ability to form clots.

For more information contact Diane Lape at 503 418-2138 or by email at