OHSU

sophia Bornstein, MD, PhD

sbornsteinTitle:

Resident

Department:

Radiation Medicine

Specialty:

Radiation Medicine

Residency:

Oregon Health & Science University, Portland, Oregon

Resident Year:

PGY-5, 2014 - 2015, Oregon Health & Science University, Portland, OR
PGY-4 (Internal Medicine Preliminary Year), starting June 2010

Internship:

Preliminary Year (PGY-1), Providence St Vincent Medical Center, Portland, OR, 2010-2011

Radiation Oncology Training:

PGY-4 Oregon Health & Science University, 2011-2015.

Undergraduate:

BS, Biochemistry, Notre Dame de Namur University, Belmont, CA, 2002

Medical School:

MD PhD, Oregon Health & Science University, Portland, OR, 2010

Interest and Accomplishments:

Head and neck and GI malignancies, targeted cancer therapy, cancer mouse models, DNA repair and genomic instability, cancer stem cells, stem cell regeneration of radiation-induced cell damage.

Hobbies:

opera, jazz piano, hiking, eastern philosophy

Publications:

Bornstein S, White R, Malkoski SP, Oka M, Han G, Cleaver T, Reh D, Anderson P, Gross N, Olson S, Deng C, Lu SL, Wang XJ. Smad4 Loss Causes Spontaneous Head and Neck Cancer with Increased Genomic Instability and Inflammation. J Clin Invest. 2009 Nov; 119(11):3408-19..

Bornstein S, Han G, Hoot K, Lu SL, Wang XJ. TGF?-Mediated Epithelial Mesenchymal Transition and Metastasis in Skin and Head-and-Neck Cancer. New Trends in the Molecular Biological Basis for Clinical Oncology. 2009 Apr 5; doi: 10.1007/978-4-431-88663-1.

Bornstein S. Role of Smad4 Loss in Head and Neck Squamous Cell Carcinoma. PhD Dissertation. Oregon Health & Science University. 2008 July..

Bornstein S, Hoot K, Han G, Lu SL, Wang XJ. Distinct Roles of Individual Smads in Skin Carcinogenesis. Mol Carcinog. 2007 Aug; 46(8):660-4.

Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D, Tang CF, Siddiqui Y, Nord J, Andersen P, Corless C, Wang XJ. Loss of transforming growth factor- type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 2006 May 15; 20(10):1331-42.

Hodgson JG, Malek T, Bornstein S, Hariono S, Ginzinger DG, Muller WJ, Gray JW. Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res. 2005 Nov 1; 65(21):9695-704.

Melese SL, Bornstein S. “Micro-BRDF Laboratory: Measurements of Light Modulation by Small Surface Tilts.” SRI International. Menlo Park, California, November, 1998. *SRI Technical Note.

Conference Presentations:

Bornstein S, Owens P, Li Y, Weber S, Herrington H, Wang XJ, Lu SL. An integrative in vivo analysis of PIK3CA, PTEN, and AKT alterations in head and neck squamous cell carcinoma. American Association of Cancer Research 100th Annual Meeting, Denver, Colorado, April 18-22, 2009.

White R, Lu SL, Bornstein S, Salter K, Olson S, Anderson P, Reh D, Malkoski S, Deng C, Wang XJ. Smad4 deletion leads to spontaneous head and neck cancer formation associated with genomic instability. American Association of Cancer Research 100th Annual Meeting, Denver, Colorado, April 18-22, 2009.

White R, Lu SL, Bornstein S, Salter K, Olson S, Anderson P, Reh D, Malkoski SP, Deng C, Wang XJ. Smad4 Deletion Leads to Spontaneous Head and Neck Cancer Formation Associated with Reduced Expression of FancA and Brca1. Twentieth Annual Fanconi Anemia Research Fund Scientific Symposium, Eugene, Oregon, October 4-7, 2008.

Bornstein S, Lu, SL, Hoot K, White R, Anderson P, Corless C, Deng C, Wang XJ. Role of TGF? Signaling-Mediated Inflammation in HNSCC Carcinogenesis. 7th International Conference on Head and Neck Cancer. San Francisco, California, July 19-23, 2008.

White R, Lu SL, Bornstein S, Salter K, Olson S, Anderson P, Reh D, Malkoski S, Deng C, Wang XJ. Smad4 Deletion Leads to Spontaneous Head and Neck Cancer Formation Associated with Genomic Instability. 7th International Conference on Head and Neck Cancer. San Francisco, California, July 19-23, 2008. *Poster of Distinction.

Wu VF, Bornstein S, Anderson PE, Gross ND, Wang XJ, Lu SL. Downregulation of Let-7 MicroRNA Correlates with Ras Overexpression in Head and Neck Squamous Cell Carcinoma. 7th International Conference on Head and Neck Cancer. San Francisco, California, July 19-23, 2008.

Weber S, Bornstein S, Herrington H, Malkoski S, Wang D, Li Y, Rustgi A, Wang XJ, Lu SL.Tobacco-Specific Carcinogen NNK Induces AKT Activation in Head and Neck Epithelia. 7th International Conference on Head and Neck Cancer. San Francisco, California, July 19-23, 2008.

Bornstein S, Lu SL, Reh D, Malkoski SP, Salter K, Hoot K, Olson S, Anderson P, Deng C, Wang XJ. Deletion of Smad4 Leads to Head and Neck Squamous Cell Carcinoma Formation through Increased Genomic Instability and Inflammation. Keystone Symposia on TGF-? in Homeostasis and Disease. Santa Fe, New Mexico, February 3-8, 2008.

Bornstein S, Lu SL, Reh D, Malkoski SP, Salter K, Hoot K, Olson S, Anderson P, Deng C, Wang XJ. Deletion of Smad4 Leads to Head and Neck Squamous Cell Carcinoma Formation through Increased Genomic Instability and Inflammation. Mouse Models of Human Cancers Consortium. Bethesda, Maryland, January 7-8, 2008.

Bornstein S, Lu SL, Malkowski SP, Salter K, Reh D, Herrington H, Corless C, Wang XJ. Smad4 Deletion Initiates Carcinogenesis through Initiating Genomic Instability. 2nd Symposium of SCBA-Oregon. Portland, Oregon, April 21, 2007.

Lu SL, Bornstein S, Wang XJ. Developing Mouse Models for Head and Neck Cancer. AACR Special Conference in Cancer Research: Advances and Challenges in Aerodigestive Epithelial Cancer: Genetics, Diagnosis, and Therapy. Charleston, South Carolina, Feb 6-9, 2007.

Weber S, Herrington H, Bornstein S, Malkowski S, Wang D, Wang XJ, Rustgi A, Lu SL. Tobacco-specific carcinogen Nitrosamine 4-(methylnitrosamino)-1-butanone rapidly induces AKT activation in head and neck epithelia. AACR Special Conference in Cancer Research: Advances and Challenges in Aerodigestive Epithelial Cancer: Genetics, Diagnosis, and Therapy. Charleston, South Carolina, Feb 6-9, 2007.

Bornstein S, Lu SL, Wang XJ. Activation of K- or H-Ras in combination with TGF?RII deletion from mouse head and neck epithelia caused metastatic head and neck squamous cell carcinoma (HNSCC) with complete penetrance. 5th Annual Timberline Symposium on Epithelial Cell Biology. Mt Hood, Oregon, February 4-7, 2006.