Jacob Raber, PhD
Behavioral Neuroscience, Neurology, and Radiation Medicine
Affiliate Scientist, Division of Neuroscience, ONPRC
Characterization of detrimental effects of genetic and environmental factors on the brain and to develop treatments to antagonize these effects. For the genetic factor, we particularly study the isoform-dependent effects of apoE. The three major human apoE isoforms (apoE2, apoE3, and apoE4) differ in their risk to develop cognitive impairments with age and following environmental challenges. As environmental factors, we focus on cognitive impairments due to exposure of the adult brain to radiation.
1980-1983 Free University, Amsterdam, The Netherlands; BSc in Chemistry, 1983
1983-1986 Free University, Amsterdam, The Netherlands; MSc in Pharmacochemistry; Thesis Title: Desensitization of adrenergic receptors. Minor in Immunochemistry; Second Minor in Yiddish language and literature
1986-1991 The Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Genetics and Virology; Ph.D. in Molecular Genetics and Virology, 1991.
Thesis Title: Regulation of expression of the Interferon induced 2'-5' oligo A synthetase, in relation to cell growth and differentiation, viral infection and drugs affecting intracellular pathways. Advisor: Michel Revel, M.D., Ph.D.
1991-1995 Postdoctoral Researcher at the Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, with Dr. F. E. Bloom
Professor, Departments of Behavioral Neuroscience, Neurology, and Radiation Medcine. Affiliate Scientist, Division of Neuroscience, ONPRC Member, Knight Cardiovascular Institute and Knight Cancer Institute
Effects of genetic and environmental factors on the brain and to develop treatments to antagonize these effects. Patents: (2000) 'Gene expression by positive feedback activation of a cell type-specific promoter'. Vile RG, Gough MJ #09/721,391.
Antino R. Allen, Kirsten Eilertson, Sourabh Sharma, Jennifer Baure, Barrett Allen, David Leu, Susanna Rosi, Jacob Raber, Ting-Ting Huangg,and John R. Fikec Delayed Administration of Alpha-Difluoromethylornithine Prevents Hippocampus-Dependent Cognitive Impairment after Single and Combined Injury in Mice
RADIATION RESEARCH 182, 489–498 (2014) http://www.ncbi.nlm.nih.gov/pubmed/25375198
Jacob Raber, Emil Rudobeck, Mary Campbell-Beachler, Antino R. Allen, Barrett Allen, Susanna Rosi,Gregory A Nelson, Shaila Ramachandran, Jennifer Turner, John R. Fiked, and Roman Vlkolinsky. Silicon Radiation-Induced Enhancement of Synaptic Plasticity in the Hippocampus of Naıve and Cognitively Tested Mice
Raber, J., Rola, R., LeFevour, A., Morhardt, D., Curley, J., Mizumatsu, S., Fike, J.R. (2004) Radiation–induced cognitive impairments associated with changes in hippocampal neurogenesis. Radiation Research 162, 39-47.http://www.ncbi.nlm.nih.gov/pubmed/15222778
Raber, J., Fan, Y., Matsumori, Y., Weinstein, P.R., Fike, J., Liu, J. (2004) Irradiation attenuates neurogenesis in the dentate gyrus and exacerbates ischemia-induced functional deficits. Annals of Neurology, 55, 381-390. http://www.ncbi.nlm.nih.gov/pubmed/14991816
Rola, R., Raber, J., Risk, A, Vandenberg, S., Morhardt, D.T., Otsuka, S, Fike, J.R. (2004) Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Experimental Neurology 188, 316-330. http://www.ncbi.nlm.nih.gov/pubmed/15246832
Villasana, L., Poage, C., van Meer, P., Raber, J. (2008) Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice. Radiation Biology Radioecology, 48, 191-194. http://www.ncbi.nlm.nih.gov/pubmed/18666648
Acevedo, S.F., McGinnis, G., Raber, J. (2008) Effects of 137Cesium irradiation on cognitive performance and measures of anxiety of Apoe-/- and wild-type female mice. Radiation Research, 170, 168-184.
Acevedo, S.F., Tittle, S., Raber, J. (2008) Transgenic expression of androgen receptors improves spatial memory retention of sham-irradiated and 137Cesium irradiated female mice. Radiation Research, 170, 161-167. http://www.ncbi.nlm.nih.gov/pubmed/18959467
Villasana, L., Rosenberg, J., Raber, J. (2010) Sex-dependent effects of 56Fe irradiation on contextual fear conditioning. Hippocampus, 20, 19-23.
Villasana, L., Pfankuch, T., Raber, J. (2010) Isoform-Dependent Effects of apoE on Doublecortin-Positive Cells and Microtubule-Associated Protein 2 Immunoreactivity following 137Cs Irradiation. Radiation and Environmental Biophysics, 49, 421-426. http://www.ncbi.nlm.nih.gov/pubmed/20458592
Villasana, L.E., Benice, T.S., Raber, J. (2010) Long-term effects of 56Fe irradiation on spatial memory of mice: Role of sex and apoE-isoform. International Journal of Radiation Oncology Biology Physics, 80, 567-573. PMID: 21549250 http://www.ncbi.nlm.nih.gov/pubmed/21549250
Dayger, C., Villasana, L., Pfankuch, T., Davis, M., Raber, J. (2010) Effects of the SARM ACA-264184 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice, Brain Research, 1381, 134-140. http://www.ncbi.nlm.nih.gov/pubmed/21219889
Raber, J. Villasana, L., Rosenberg, J., Zou, Y., Huang, T. T., Fike, J.R. (2011) Irradiation enhances hippocampus-dependent cognition in extracellular superoxide dismutase deficient mice. Hippocampus, 21, 72-80.
Raber, J., Rosi, S., Chakraborti, A., Fishman, K., Dayger, C., Davis, M.J., Villasana, L, Fike, J.R. (2011) Effects of 56Fe cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. Radiation Research, 80, 567-573. http://www.ncbi.nlm.nih.gov/pubmed/?term=raber+j+%2B+dayger+%2B+fishman
Haley, G.E., Villasana, L., Dayger, C., Davis, M.J., Raber, J. (2012) ApoE Genotype-Dependent Paradoxical Short-Term Effects of 56Fe Irradiation on the Brain. International Journal of Radiation Oncology Biology Physics, 84, 793-799. http://www.ncbi.nlm.nih.gov/pubmed/22401921
Villasana, L., Rosenthal, R., Doctrow, S., Pfankuch, T., Zuoloaga, D.G., PhD; MacColl Garfinkel, A., Raber, J. (2012). Effects of alpha-lipoic acid on associative and spatial memory of sham-irradiated and 56Fe-irradiated C57BL/6J male mice. Pharmacology, Biochemistry, and Behavior, 103, 487-493 http://www.ncbi.nlm.nih.gov/pubmed/23051895
Haley, G.E., Yeiser, L., Olsen, R., Davis, M.J., Johnson, L.A., Raber, J. (2013) Early effects of whole body 56Fe irradiation on hippocampal function in C57BL/6J mice. Radiation Research, 179, 590-596. http://www.ncbi.nlm.nih.gov/pubmed/23510274
Raber, J., Allen, A., Rosi, S., Sharma, S., Dayger, C., Davis, M.J., Fike, J.R. (2013) Effects of whole body 56Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus. Behavioural Brain Research, in press
Raber, J., Allen, A., Rosi, S., Sharma, S., Dayger, C., Davis, M.J., Fike, J.R. (2013) Effects of 56Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2). Behavioural Brain Research, in press
Raber. J., Rudobeck, E., Campbell-Beachler, M., Allen, A.R., Allen, B., Rosi, S., Nelson, G.A. Ramachandran, S., Turner, J., Fike, J.R., Vlkolinsky, R. (2013) 28Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice. Radiation Research, in press
Links of Interest
- Effect of behavioral testing on spine density of basal dendrites in the CA1 region of the hippocampus modulated by (56)Fe irradiation(PDF)
methamphetamine exposure prior to middle cerebral artery occlusion increases
infarct volume and worsens cognitive injury in Male mice(PDF)
irradiation induces persistent and tissue-specific DNA methylation changes in
the left ventricle and hippocampus(PDF)
- Wendy McGinnis presented at the Society for Neuroscience meeting
- Wendy McGinnis presented at the 2015 Wisconsin Symposium on Emotion
- OHSU’s Inter-disciplinary Radiobiology Team Presents Original Research