Yiyi Chen, PhD

Associate Professor


BA (1998) Zhejiang University, Economics
MA (2001) Fudan University, Economics
MA (2004) University of Iowa, Economics
MS (2005) University of Iowa, Biostatistics
PhD (2008) University of Iowa, Biostatistics

Major Areas of research

Design and analysis of clinical trials; Bayesian statistics

Experience and Interests

Dr. Chen is a biostatistician with primary interest in oncology clinical trials and cancer research. Her current interest is in adaptive design for early phase clinical trials, Diagnostic Medicine, Statistical Methods for Personalized Medicine and Big Data for Public Health and Medicine.

Selected Publications

Schlansky B, Chen Y, Scott DL, Austin D, Naugler WE (2014). Waiting Time Predicts Survival after Liver Transplantation for Hepatocellular Carcinoma: a Cohort Study in the UNOS Registry. Liver Transplantation. doi: 10.1002/lt.23917.

Cowan N, Chen Y, Downs T, Bochner B, Apolo A, Porter MP, Rochelle JL, Amling C, Koppie T (2014). Neoadjuvant Chemotherapy Use in Bladder Cancer: A Survey of Current Practice and Opinions. Advances in Urology.

Huang W, Li X, Chen Y, Li X, Chang M-C, Oborski M, Malyarenko D, Muzi M, Jajamovich GH, Fedorov A, Tudorica A, Gupta SN, Laymon CM, Marro KI, Dyvorne HA, Miller JV, Barboriak DP, Chenevert TL, Yankeelov TE, Mountz JM, Kinahan PE, Kikinis R, Taouli B, Fennessy F, Kalpathy-Cramer J (2014). Variations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Evaluation of Breast Cancer Therapy Response: A Multicenter Data Analysis Challenge. Translational Oncology. 7(1):153-66.

VanDlac AA, Cowan NG, Chen Y, Anderson RE, Conlin MJ, La Rochelle JC, Amling CL, Koppie TM (2013). Timing, Incidence, and Risk Factors of Venous Thromboembolism in Patients Undergoing Radical Cystectomy for Malignancy: A Case for Extended Duration Pharmacologic Prophylaxis. The Journal of Urology. 191(4):943-7.

Chen Y, Chen Z, Motomi M (2012). A New Statistical Decision Rule for Single-arm Phase II Oncology Trials. Statistical Methods in Medical Research. doi: 10.1177/0962280212442584.

Tudorica LA, Oh KY, Roy N, Kettler MD, Chen Y, Hemmingson SL, Afzal A, Grinstead JW, Laub G, Li X, Huang W (2012) A Feasible High Spatiotemporal Resolution Breast DCE-MRI Protocol for Clinical Settings. Magnetic Resonance Imaging. 30(9):1257-67.

Tanyi JA, Doss EJ, Kato CM, Monaco DL, Meng LZ, Chen Y, Kubicky CD, Marquez CM, Fuss M (2012). Dynamic Conformal Arc Cranial Stereotactic Radiosurgery: Implications of Multileaf Collimator Margin on Dose-volume Metrics. The British Journal of Radiology. The British Journal of Radiology. 85(1019):e1058-66.

Larsen GK, Evans J, Lambert WE, Chen Y. Raitt M (2011). Shocks Burden and Increased Mortality in Implantable Cardioverter Defibrillator Patients. Heart Rhythm. 8(12):1881-6.

Tanyi JA, Kato C, Chen Y, Chen Z, and Fuss M (2011). Impact of the High-definition Multileaf Collimator (HD-MLC) on Linear-accelerator-based Intracranial Stereotactic Radiosurgery (SRS).  British Journal of Radiology. 84(1003):629-38.

Spurgeon SE, Pindyck T, Okada C, Chen Y, Chen Z, Mater E, Abbi K, & Epner EM (2011). Cladribine Plus Rituximab is an Effective Therapy for Newly Diagnosed Mantle Cell Lymphoma. Leukemia & Lymphoma 52(8):1488-94.

Chen Y and Smith BJ (2009). Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. Statistics in Medicine 28: 3347-3362.

Tanyi JA, Summers PA, McCracken CL, Chen Y, Ku L-C and Fuss M (2009). Implications of a High-Definition Multi Leaf Collimator (HD-MLC) on Treatment Planning Techniques for Stereotactic Body Radiation Therapy (SBRT): a Planning Study. Radiation Oncology. 10, 4:22.

Polgreen PM, Chen Y, Beekmann S, Srinivasan A, Neill MA, Gay T and Cavanaugh JE (2008).  Elements of Influenza Vaccination Programs that Predict higher Vaccination Rates: Results of an Emerging Infections Network Survey.  Clinical Infectious Diseases, 46(1), 14-19.

Herwaldt LA, Appelgate D, Kuntz J, Chen Y and Pottinger J (2007). Infection Control Resources in Iowa. American Journal of Infection Control, 35(10), 662-665.

Quinn LK, Chen Y, and Herwaldt LA (2007).  Survey of Long-Term Care Facilities in Iowa for Policies and Practices Regarding Residents with Clostridium Difficile Infection.  Infection Control and Hospital Epidemiology, 28(11), 1228-1232.

Polgreen P, Chen Y, Cavanaugh J, Ward M, Coffman S, Hornick D, Diekema DJ, Herwaldt LA(2007). An Outbreak of Severe Clostridium Difficile-Associated Disease Possibly Related to Inappropriate Antimicrobial Therapy for Community-Acquired Pneumonia. Infection Control and Hospital Epidemiology, 28(2), 212-214.

Polgreen P, Beekmann SE, Chen Y, Doern GV, Pfaller MA, Brueggemann AB, Herwaldt LA, Diekema DJ (2006). Epidemiology of Methicillin-Resistant Staphylococcus Aureus and Vancomycin-Resistant Enterococcus in a Rural State. Infection Control and Hospital Epidemiology, 27(3), 252-256.