Lead investigator. This aspect of the ADHD Program is directed by Dr. Nigg.
Funding. This work has received intramural funding from the OHSU Office of the Vice President, from the OHSU Moore Foundation, and from philanthropic funds through the Department of Psychiatry.
OHSU co-Investigators. Elinor Sullivan, Ph.D., Jackilen Shannon, Ph.D., Diane Stadler, Ph.D., Jennifer Loftis, Ph.D., Damien Fair, Ph.D. This work is also supported by the OCTRI core facility bionutrition team.
Outside OHSU collaborators and consultants. Martha Cox, Ph.D. (University of North Carolina), Cathi Propper (Ph.D), University of North Carolina, Jeffrey Measelle, Ph.D. (University of Oregon), John Richards, Ph.D. (University of South Carolina), John Gilmore, M.D., (University of North Carolina), Jennifer Ablow, Ph.D. (University of Oregon), Steve West, Ph.D. (University of Arizona), Ben Lahey, Ph.D., University of Chicago.
Aims. This initiative seeks to create a cohort of infants followed from the second trimester of their mother's pregnancy, to examine prenatal and postnatal predictors and identify early life biomarkers of future ADHD onset. We plan to examine nutrition, stress, and environmental toxicant effects in relation to offspring behavior. We can also examine epigenetic effects. Finally, we are conducting MRI scans of infants to identify brain biomarkers of prenatal risk and post-natal future outcome.
Productivity. To date this new pilot effort has enrolled a cohort of 50 women and the oldest of the offspring are now 36 months of age. We are conducting initial data analysis to examine prenatal predictors of infant behavior, with papers in preparation. We have submitted several large grant proposals and continue to seek funding to expand this pilot project.