Suzanne Mitchell, Ph.D.
OHSU Department of Behavioral Neuroscience
State University of New York at Stony Brook
Impulsive decision-making including the basic neurocognitive mechanisms underlying this process and its relationship to drug abuse.
Current Extramurally Funded Research
SHM Ongoing Research Support
R03 DA024195 Mitchell (PI) 05/15/09 - 05/14/10
Imaging temporal discounting in smokers and nonsmokers The main goal of the project is to identify the neural substrates of impulsive decision making associated with chronic exposure to drugs of abuse. This project focuses on differences in brain activation patterns in smokers and nonsmokers corresponding to the behavioral differences on a temporal discounting task using functional magnetic resonance imaging (fMRI) techniques. Role: PI
R01 DA016727 – Mitchell (PI) 02/01/05 - 01/31/11 (no cost extension) NIH/NIDA
Reinforcer efficacy: Measures and neural mechanisms The main goal of this project is to evaluate the impact of delay, uncertainty and effort on reinforcer efficacy in rats and to examine the effects of behavioral and drug manipulations on the valuation of rewards. Role: PI
R03 DA027580 Mitchell (PI) 09/30/09 - 08/31/12
Exercise-induced changes in impulsivity and cocaine self-administration The overall aim of the proposed research is to understand the effects of exercise on impulsivity (delay discounting) and drug use (cocaine self-administration), and to determine whether there is a common mechanism underlying these effects.
P50 DA018165 Janowsky (Center PI) 09/01/06 - 11/30/10
Methamphetamine Abuse Research Center Research in the Methamphetamine Abuse Research Center (MARC) focuses on four themes: neuroadaptation to MA, neuroanatomical locations, relationship to impulsivity and stressor responsivity.
P60 AA10760 Crabbe (Center PI) 01/01/06 - 12/31/10
Behavioral Genomics of Alcohol Neuroadaptation The Portland Alcohol Research Center (PARC) addresses goals related to etiology and prediction of risk of alcohol abuse, alcoholism, and specific alcohol-related health problems. One hypothesis developed from the synthesis of PARC findings with other connected projects is that impulsivity is a significant genetic risk factor for high alcohol drinking. The groundwork to test this hypothesis will be laid in Component 8, where mouse models of impulsivity and drinking. Role: Component PI R01
DA021695 Waldron (PI) 09/01/07 - 05/31/11
Development of a family-based treatment for adolescent methamphetamine abuse The main goal of the project is to evaluate the potential of an intervention that integrates family therapy with age-appropriate elements from adult treatment programs. To inform the treatment approach, fMRI and behavioral procedures will be used to assess changes in the function of decision-making reward pathways known to be affected by methamphetamine.