Morgan Research Laboratory

Our primary research mission is to determine how abnormal blood flow to the placenta leads to common maternal pregnancy complications and fetal programming of adult onset disease in their progeny. In about 10% of pregnancies, uteroplacental blood flow does not work properly, leading to small babies, early labor, and/or pregnancy-induced hypertension. Small babies have an increased risk of developing heart disease, diabetes, essential hypertension, and some cancers as adults. We study a transgenic mouse model that simulates a common human angiotensinogen (AGT) promoter variant that is associated with fetal growth restriction and maternal pregnancy-induced hypertension. Our potential breakthrough using novel “microbubble technology” has been to discover that these mice have faster blood flow to their placentas and lack conspicuous spiraling of their uterine spiral arteries. We plan to investigate the effects of faster uteroplacental blood flow on nutrient transfer between mother and baby, fetal cardiovascular development, and epigenetic regulation of gene expression in their kidneys to help us better understand the molecular pathways involved in fetal programming of common adult onset diseases.



Terry K. Morgan, MD, PhD
Associate Professor of Pathology and Obsetrics & Gynecology, OHSU
Principal Investigator

Jessica Hebert, BS
PhD Graduate Student, PSU
Laboratory Technician

Amy Schilling, BS
Research Associate
Laboratory Technician

Mayu Morita
Research Associate
Laboratory Technician


Martha Choate Monson, MD
Ob/Gyn Resident, University of Utah
Research Technician, 2007 - 2008

Ross Anderson, MD
OHSU Medical School
Research Technician, 2008 - 2009

Elisabeth DuPriest, PhD
Assistant Professor, Warner Pacific University
Post-Doctoral Fellow, 2008 - 2009

Emily King Meserve, MD, MPH
Pathology Resident, Harvard University
MD/MPH Graduate Student, 2007 - 2010

James Sinclair, MS
Law Student, Lewis & Clark
Work Study Student, 2009 - 2011