OHSU

Cong-Qiu Chu MD, PhD

Cong-Qiu Chu, MD, PhDCong-Qiu Chu, MD, PhD
Assistant Professor of Medicine, OHSU
Director, OHSU Early Arthritis Clinic
Staff Rheumatologist, Portland VA Medical Center
Course Director, Immunology for Rheumatology Fellows

Education and Training

Medical School: Jilin University Norman Bethune Medical College Changchun, Jilin, China
IM Residency: Wayne State University Medical School, Detroit, Michigan
Rheumatology Fellowship: University of Washington Medical School, Seattle, Washington

Biography

Dr. Chu is keenly interested in gaining insights into the pathogenesis and management of rheumatoid arthritis (RA). His contributions include the seminal finding that identified tumor necrosis factor (TNF) as a target for RA therapy. Dr. Chu's research on the role of T cells in arthritis and other autoimmune diseases helped to identify Th17 rather than Th1 cells as pathogenic T cells in arthritis models of RA. His current research is focused on using small interfering RNA (siRNA) to target IL-17 in Th17 cells for therapy in RA and other autoimmune inflammatory diseases. Dr. Chu now leads the OHSU Early Arthritis Clinic and works on strategies to induce and maintain remission in early RA in clinical studies.

Recent Publications

  1. Chu CQ, Field M, Feldmann M, Maini RN. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum. 1991, 34(9):1125-32.
  2. Chu CQ, Wittmer S, Dalton DK. Failure to suppress the expansion of the activated CD4 T cell population in interferon-gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med. 2000, 192(1):123-8.
  3. Chu CQ, g regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum. 2007, 56(4):1145-1151.
  4. Morita Y, Ismail DM, Keith B. Elkon KB, Chu CQ.Dichotomous response to TGF-β after TCR activation by naïve CD4+ T cells from DBA/1 mice: enhanced RORgt yet reduced Foxp3 expression. Arthritis Rheum. 2011, 63: 118-26.
  5. Yomogida K, Chou Y, Pang J, Baravati B, Maniaci BJ, Wu S, Zhu Y and Chu CQ. Streptavidin suppresses T cell activation and inhibits IL-2 production and CD25 expression. Cytokine, 2012, 58:431-6
  6. Yomogida K, Wu S, Baravati B, Avendano C, Caldwell T, Maniaci B, Zhu Y and Chu CQ. Cell penetrating recombinant Foxp3 protein enhances Treg function and ameliorates arthritis. Biochem Biophys Res Commun, 2013, in press

 

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