OHSU

Richard Bryant, MD

Richard Bryant, MD

Richard Bryant, MD
Professor Emeritus of Medicine
Division of Infectious Diseases, OHSU

Degrees:

B.S. – Southern Methodist University , 1954
M.D. – Washington University School of Medicine, 1958

Residency:

Medicine – Yale University SOM, New Haven, CT, 1958-1959
Medicine – University of Texas , Southwestern Medical School, 1959-1961

Fellowship:

ID – Southwestern Medical School, 1961-1962
USAF – ID Officer – Willford Hall USAF Hospital, Lackland AFB, TX 1962-1964
ID – Vanderbilt University Medical School, 1964-1965

Research Interest:

Abscesses and suppurative infection

Clinical Interests:

Abscesses, Pneumonia, osteomyelitis, Lyme disease

Representative Publications:

  1. Bryant RE, Hood AF, Hood CE, Koenig MG. Factors affecting mortality of gram-negative rod bacteremia. Arch Int Med 1971; 127:120.
  2. Wray TM, Bryant RE, Killen DA. Sternal osteomyelitis and costochondritis following median sternotomy. J Thor & Cardiovas Surg 1973; 65:277.
  3. Bryant RE, Stucliffe MC. The effect of cyclic 3', 5'-adenosine monophosphate on granulocyte adhesion. J of Clin Invest 1974; 54:1241.
  4. Bryant RE, Hammond D. Interaction of purulent material with antibiotics used to treat Pseudomonas infections. Antimicrobial Agents and Chemo 1974; 6:902.
  5. Bryant RE, Alford RH. Unsuccessful treatment of staphylococcal endocarditis with cefazolin. JAMA 1977; 237:569.
  6. Kimbrough RC, III, Bryant RE. Infective Endocarditis. S. Rahimtoola (ed.). New York : Grune & Stratton, December 1977.
  7. Bryant RE, Rashad A, Mazza J, Hammond D. B-lactamase activity in human pus. J Inf Dis 1980; 142:594.
  8. Bryant RE. Endocarditis and valve-ring abscess caused by Staphylococcus epidermidis – an opportunistic pathogen keeping pace with progress. Medical Grand Rounds 1982; 1:3,245.
  9. Korzeniowski O, Sande MA, The National Collaborative Endocarditis Study Group. Combination antimicrobial therapy for Staphylococcus aureus endocarditis in patients addicted to parenteral drugs and in non addicts. Ann Int Med 1982; 97:496.
  10. Norden C, Fierer J, Bryant RE, Morthland V, The Chronic Staphylococcal Osteomyelitits Study Group. Chronic staphylococcal osteomyelitis: Treatment with regimens containing rifampin. Rev Inf Dis 1983; 5(Suppl 3):495.
  11. Chambers HF, Korzeniowski OM , Sande MA, The National Collaborative Endocarditis Study Group. Staphylococcus aureus endocarditis. Clinical manifestations in addicts and nonaddicts. Medicine 1983; 62:170.
  12. Bryant RE. Viral pneumonia. Infectious Diseases and Microbiology, A Brande, C Davis, J Flerer (eds.). 2nd edition. Philadelphia : WB Saunders Co., 1986.
  13. Norden C, Bryant RE, et al. Controlled clinical trial of therapy with either nafcillin or nafcillin plus rifampin in chronic osteomyelitis caused by S. aureus. Southern Medical Journal 1986; 78:8;947.
  14. Bryant RE. Pus: Friend or foe. Contemporary Issues in Infectious Diseases: New Surgical and Medical Approaches, Vol V. R Root, D Trunkey and M Sande (eds.). New York : Churchill Livingstone, Inc., 1987.
  15. Bryant RE, Mazza JA. Effect of the abscess environment on the antimicrobial activity of ciprofloxacin. American Journal of Medicine 1989; 87:5A-23S.
  16. Drach F, Bryant RE. Spotting pneumococcus in today's pneumonia milieu. J Resp Dis 1993; 14:198-216.
  17. Drach F, Bryant RE. Pneumococcal pneumonia: Update on therapy. J Resp Dis 1993; 14:586-597.
  18. Bryant RE. Skin and subcutaneous infections. Internal Medicine, 5th Ed. Stein JH, (ed-in-chief). Mosby , Missouri , 1998:1419-1425.
  19. Bryant RE. Pleural Effusion and Empyema. Principles and Practices of Infectious Diseases. Mandell GL, Bennett JE, Dolin R (eds.) Philadelphia , PA : Churchill Livingstone, 2000.

Biosketch:

My research interests have focused on factors affecting white blood cell participation in the inflammatory process and on the effect of absesses on antimicrobial efficacy. Our work helped to characterize the composition of pus including physical, chemical, and electrolyte concentrations thereof. We identified B lactase in pus from patients with polymicrobic anaerobic infection and studied animal models to characterize the relevance of those findings. We identified abscess components capable of binding aminoglycoside antibiotics and demonstrated the DNA in absesses were capable of binding fluoroquinolone antibiotics. The impact of the abscess environment of antibiotic efficacy is a continuing clinical interest.

I'm interested in the role of infection and inflammation in the syndromes of chronic fatigue. There is a a gradual expansion of knowledge concerning the effects of treatment of these disorders..

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