Bill B. Messer, MD, PhD

Bill Messer, MDBill B. Messer, MD, PhD
Assistant Professor of Medicine
Division of Infectious Diseases, OHSU


MD, University of North Carolina at Chapel Hill School of Medicine, 2006
PhD, University of North Carolina at Chapel Hill, 2003


Internal Medicine, University of North Carolina Hospitals, Chapel Hill, NC, 2009


Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, 2012

Research Interest:

Dr. Messer's research focuses on dengue virus, a pathogen transmitted by mosquitos and endemic throughout the tropical and sub-tropical world.  His particular interest is in viral genetics and evolution and how those factors affect viral fitness, viral pathogenicity and the human immune response to dengue virus infection.  Dr. Messer's has three areas of active research: 1) the genetic determinants of virus fitness in the mosquito vector Aedes aegypti, 2) vaccine strategies that provide robust cross-protective immunity to dengue infection, and 3) using reverse genetics to identify mutations critical to viral RNA function and to virus mouse adaptation.

Clinical Interest:

Dr. Messer is trained in diagnosing and treating infections in the general population, international travelers and immune compromised hosts, including long-term management of HIV patients.


Dr. Messer completed his PhD in Ecology in 2003 under the mentorship of Dr. Tom Whitmore in the Department of Geography and in the lab of Dr. Aravinda de Silva in the Department of Microbiology and Immunology at UNC Chapel Hill.  His dissertation focused on the evolution of dengue virus serotype 3 and the emergence of dengue hemorrhagic fever in Sri Lanka.  After completing his MD and residency and his residency in Internal Medicine at UNC in 2008 he joined the lab of Dr. Ralph Baric where he took primary responsibility for the dengue virus research program, supported by the Southeast Regional Center for Excellence in Biodefense.   In May, 2012, following completion of his fellowship in Infectious Diseases, Dr. Messer was appointed Clinical Assistant Professor in the Department of Medicine in the UNC School of Medicine. In November, 2012, Dr. Messer joined the faculty in the Departments of Medicine and Molecular Microbiology and Immunology at Oregon Health & Science University as an Assistant Professor where he continues to study dengue virus genetics.

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