The intensive mentorship portion of this research experience will reflect each scholar's interests and career goals as an EM researcher. As they begin the training program, scholars will meet with several potential mentors and, with the guidance of program leadership, will select two primary mentors:
- A research mentor whose content and methodological expertise match the interests of the scholar; and
- A career development mentor whose career trajectory has been similar to the intended trajectory of the scholar.
Scholars will draw from a mentorship team of over 35 seasoned researchers from 18 departments, divisions, institutes and schools within OHSU – allowing research foci from bench-to-bedside, to community, to policy-making, in a broad range of content areas.
Areas of Focus
MentorsThe below divisions, departments, institutes and centers are listed with related mentors. Many mentors have multiple departmental appointments, enhancing institutional collaboration.
Eric Orwoll, MD, FACP, is Director of the OCTRI, Professor of Medicine, Program Director for the OHSU Bone & Mineral Unit, Associate Dean for Research in the School of Medicine, and Associate Vice President for Research. Dr. Orwoll's research interests include the epidemiology, etiology and therapy of osteoporosis, the effects of sex steroids on skeletal biology, skeletal genetics, and the regulation of the androgen receptor in osteoblasts. He is the PI of several NIH research grants, including Osteoporotic Fractures in Men (MrOS), and has authored over 150 peer reviewed publications, reviews, book chapters, and books.
OCTRI faculty members listed elsewhere: Morris
Nabil Alkayed, MD, is Professor of Anesthesiology & Perioperative Medicine, with a joint appointment in the basic science Department of Physiology & Pharmacology. He is Director of the Division of Cerebrovascular Research and Associate Director of the Research Center for Gender-Based Medicine. He serves on the Program for Molecular and Cellular Biosciences and the Neuroscience Graduate Program. His research, currently funded by NINDS, is aimed at understanding the mechanisms of ischemic cell death in brain, and at identifying vascular and non-vascular endogenous mechanisms of neuroprotection. The ultimate goal of his research is the development of novel, mechanism-based therapeutic agents against ischemic brain damage, such as occurs in stroke. Dr. Alkayed has mentored 16 trainees over the past 10 years.
Michael P. Hutchens, MD, MA, is Assistant Professor in the Department of Anesthesiology & Perioperative Medicine. He has trained many of the department's postdoctoral fellows in the Department's murine cardiac arrest model, along with macro- and micro-physiology of cardiac arrest and how it connects to organ dysfunction through molecular biology. His recent work has focused on in-vivo and in-vitro correlates of glomerular events leading to renal failure during severe ischemia-reperfusion injury such as cardiac arrest. Dr. Hutchens is currently funded under NIH K08 grant # DK090754-02.
Jeffrey Kirsch, MD, is Associate Dean for Veterans and Clinical Affairs in the OHSU School of Medicine and Professor and Chair of the Department of Anesthesiology & Perioperative Medicine. His NIH funding has included a K08 award and a program project grant for two 5 year cycles. His research has focused on the mechanism of brain injury following cerebral ischemia – both understanding the pathophysiology and defining opportunities for intervention to improve outcomes. Most of his work to address possible treatment interventions has been completed in large animal models (e.g. primate, pig, dog, cat), whereas his mechanistic research has been completed in cell culture and rodents. Over the past 20 years, he has mentored many trainees, both in the clinical environment and in their research.
Matthias Merkel, MD, PhD, is Assistant Professor in the Department of Anesthesiology & Perioperative Medicine. He serves as an anesthesiologist/intensivist in the Cardiothoracic Surgical Intensive Care Unit. His research interests focus on the mechanism of induced cardioprotection and related gender differences. His laboratory investigates novel targets of cardioprotection, focusing on the reperfusion phase following acute myocardial ischemia. Trainees in his laboratory are exposed to in vivo and in vitro models and to molecular techniques, including silencing RNA techniques to study acute myocardial ischemia-reperfusion injury and potential therapeutic approaches to reduce cell death and infarct size and to improve cardiac function.
Stephanie Murphy, VMD, PhD, is Associate Professor of Anesthesiology & Perioperative Medicine. For the past 14 years, her research has addressed gender biology and its relevance to cerebrovascular disease outcomes. She is best known for her work on the neuroprotective potential of progesterone alone or in combination with estrogen in female ischemic brain. She continues to impact the field of stroke through her studies examining sex differences and sex-specific mechanisms in anesthetic neuroprotection and preconditioning in ischemic brain – research that has direct clinical application to stroke patients in the ED. She has recently expanded her preclinical stroke research program to compare the effects of acute alcohol exposure on female versus male brain susceptibility to stroke and how that might impact on acute outcomes and management. Regarding mentorship, she has served as the chair of the Mentoring Committee within the American College of Laboratory Animal Medicine. She currently serves as a faculty mentor on 2 T32 grants at OHSU focusing on neuroscience and aging (pre- and post-doctoral trainees) and on translational training in Anesthesiology research (anesthesiology MD residents), as well as on an R25 at the Oregon National Primate Research Center for Nonhuman Primate Veterinary Clinical Education Program (DVM/VMD residents).
Anesthesiology & Perioperative Medicine faculty members listed elsewhere: Habecker, Hurn
Sumeet Chugh, MD, initiated the Oregon Sudden Unexpected Death Study (SUDS), an NHLBI-funded comprehensive assessment of sudden cardiac arrest victims in the Portland Metropolitan Area, ongoing for the last 7 years. Although his primary academic homes are now the Cedars-Sinai Heart Institute, where he serves as Section Chief of Clinical Cardiac Electrophysiology, and UCLA, where he is a Professor of Medicine-in-Residence, he continues his Portland-based research and remains an Associate Professor of EM at OHSU. This research is shedding light on the risk factors, triggers and genetic defects related to sudden cardiac arrest, with the overall goal of designing novel techniques for prevention of this condition. He has published over 130 articles and abstracts in professional journals.
Mohamud R. Daya, MD, MS, is an Associate Professor in the Department of Emergency Medicine. He combines research with his clinical and administrative expertise in Emergency Medical Services. As PI of OHSU's ROC site, he leads OHSU's participation in these pre-hospital clinical trials of therapies for cardiac arrest and major trauma; this work is informed by his role as EMS Medical Director for Tualatin Valley Fire & Rescue, Forest Grove Fire & Rescue and the Washington County 911 center. He is also a co-investigator for the Oregon SUDS project with Dr.Chugh. He chairs the EMS section within the DEM and serves as Fellowship Director for the OHSU EMS and Global Health Fellowships. Dr. Daya has a long track record in mentoring students, residents, fellows, and junior faculty in research.
O. John Ma, MD, is Professor and Chair of the Department of Emergency Medicine. His research has focused on applications of ultrasound in diagnosing injuries in trauma patients and on EMS. He also has co-edited 12 textbooks that have been published in over 10 languages. He has served as the primary scholarly activity mentor for nearly 50 residents and medical students. He has received 4 Teacher of the Year awards and the 2005 Society for Academic Emergency Medicine Excellence Award in Ultrasound Education. Dr. Ma has served as PI on several foundation-funded studies and site PI or co-investigator on federally-funded studies, enabling him to serve as a career development mentor and to work effectively with a trainee's research mentor.
K. John McConnell, PhD, is Associate Professor in the DEM and the Department of Public Health & Preventive Medicine. His research has focused on health policy and health services, with particular emphasis on trauma care and ED crowding. He is currently the PI of an R01 funded by AHRQ that investigates the clinical impact of management practices in cardiac care units. Dr. McConnell's work has been noteworthy for his close collaboration with key stakeholders, frequently working with provider groups and associations or serving as an advisor and health economist to the Oregon Legislature and state policy makers. He has served as mentor or co-mentor to EM research fellows and OHSU MPH students. He developed a new Healthcare Management MBA Program sponsored jointly by OHSU and Portland State University and currently teaches a Health Economics course in that program. He is currently the PI of an R01 funded by AHRQ that investigates the clinical impact of management practices in cardiac care units. Dr. McConnell serves as the Director of OHSU's Center for Health Systems Effectiveness.
Craig R. Warden, MD, MPH, is Associate Professor in the Departments of EM and Pediatrics. Board-certified in EM, Pediatric EM, Pediatrics, and Toxicology, he also has extensive experience in EMS – serving as Medical Director for Clackamas County Fire and Rescue and the Oregon State Urban Search & Rescue Task Force. He is a co-investigator in ROC and co-PI with Dr. Lowe of OHSU's NETT site. Dr. Warden has advanced training in geographical information systems (GIS) and is a resource to researchers interested in this tool. He has mentored 7 trainees in the past 10 years.
Emergency Medicine faculty members listed elsewhere: Fu, Lowe, Newgard, Spiro
William Hersh, MD, is Professor and Chair of the Department of Medical Informatics & Clinical Epidemiology. His research, funded by the National Library of Medicine, AHRQ, and the National Science Foundation, focuses on the development and evaluation of information retrieval systems for biomedical practitioners and researchers. He has published over 100 scientific papers and is author of the book, Information Retrieval: A Health and Biomedical Perspective. Dr. Hersh is actively involved in clinical and translational research, serving as Director of the Biomedical Informatics Program of OCTRI. He also serves as Director of Informatics Educational Programs at OHSU, where he has led the development of educational programs at the certificate, master's, and doctoral levels. He has won numerous awards for his educational innovations, including the OHSU Faculty Senate Distinguished Faculty Award for outstanding teaching in 2007 and the 2008 American Medical Informatics Association Donald A.B. Lindberg Award for Innovation in Informatics.
Paul N. Gorman, MD, is Associate Professor in the Department of Medical Informatics & Clinical Epidemiology. His research is on the use of information by clinicians in real-world problem-solving, mainly patient care. Most often, his work uses observational methods to study the activities of individuals and groups as they use information to perform real world tasks, e.g., information needs, seeking and use, naturalistic decision making, distributed cooperative problem solving, distributed cognition, and social informatics. Dr. Gorman has mentored 11 trainees in the past 10 years.
Medical Informatics & Clinical Epidemiology faculty members listed elsewhere: Guise, Lowe, Morris, Thornburg
David M. Spiro, MD, MPH, is Associate Professor of Pediatrics and of EM and Director of the Pediatric EM Section. He is closely involved with training fellows in Pediatric EM, residents in Pediatrics and EM, medical students and physician assistant students. Dr. Spiro continues to perform clinical research in the pediatric ED. He has a strong interest in the judicious use of antibiotics and has published extensively on the subject of acute otitis media. Current projects include evaluating new electrolyte solutions for rehydration of young children and evaluating a new clinical pathway for children with suspected appendicitis.
Pediatrics faculty members listed elsewhere: Warden
Thomas M. Becker, MD, PhD, is Chair of the Department of Public Health & Preventive Medicine. Trained in Internal Medicine, Preventive Medicine, Epidemiology, and Anthropology, he has substantial experience in public health-related research, particularly among special populations. Dr. Becker has conducted 20 years of epidemiologic research in collaboration with Native populations. For the last 12 years he has had grant support for an education program to increase Native researchers' skills in designing and implementing chronic disease control projects, and he has substantial experience in teaching epidemiology to medical students, public health students and junior faculty at OHSU. His infectious disease-related research interests are focused on prevention and treatment of caries-producing oral flora in American Indian children and on infectious causes of cancer. He has published extensively on health-related topics among American Indians and Hispanics and has carried out several grant-funded cancer and infectious disease-related studies among the Navajo and Pueblo peoples of New Mexico and among Northwest tribal communities. For his work in HPV epidemiology, he was awarded the Oregon Faculty Excellence in Research award by the consortium of 3 Oregon universities that host the Oregon MPH program, and he is an elected member of the Western Society for Clinical Investigation.
Rongwei (Rochelle) Fu, PhD, is Associate Professor of Public Health & Preventive Medicine and of EM. She serves as the lead biostatistician for OHSU's AHRQ-funded Evidence-Based Practice Center and is the lead biostatistician on most CPR-EM studies. She teaches several courses in OHSU's MPH program. She has a particular interest in Bayesian models and complex meta-analysis methods.
Public Health & Preventive Medicine faculty members listed elsewhere: Guise, Lowe, McConnell, Morris, Newgard
Sanjiv Kaul, MD, is Distinguished Professor of Cardiology, Professor of Medicine and Radiology. Dr. Kaul's major clinical and research interest is coronary artery disease. He is a pioneer in cardiovascular imaging, having spearheaded most of the developments in myocardial contrast echocardiography and making major contributions to the field of nuclear cardiology. He studies coronary physiology and pathophysiology both in animal models and humans. Recently, Dr. Kaul has used targeted ultrasound contrast materials (gas filled microbubbles carrying ligands to endothelial selectins or integrins) as potential molecular imaging agents. These microbubbles are useful because they have a similar intravascular rheology to that of red blood cells, and this property allows them to be detected by ultrasound. These bubbles can also be used to deliver genes and pharmacological agents. Dr. Kaul is also interested in the no reflow phenomenon following myocardial ischemia. His participation offers the trainee the opportunity to study useful state-of-the-art technology applied to patients with cardiovascular disease.
Jonathan R. Lindner, MD, is Professor of Medicine and Associate Chief for Education for the Division of Cardiovascular Medicine. Dr. Lindner has expertise in the fields of contrast chocardiography, molecular imaging, and microvascular physiology. His research laboratory is currently funded by several R01 grants. Areas of research include the following: (1) application of molecular imaging techniques to evaluate atherosclerosis, angiogenesis, ischemic injury, thrombosis/platelet adhesion, and inflammation; (2) abnormalities in microvascular function in diabetes, obesity and insulin resistance; (3) novel methods for site-targeted gene and drug delivery with ultrasound; (4) microvascular responses to acute and chronic myocardial and limb ischemia; and (5) use of sonothrombolysis in acute coronary syndromes. Dr. Lindner has mentored 17 trainees in the past 10 years.
Kevin Wei, MD, is Associate Professor in the Division of Cardiovascular Medicine. His research is on the evaluation of pathophysiologic changes in the microcirculation in the setting of coronary artery disease, and he has applied these phenomena to the non-invasive detection and quantification of coronary stenosis severity in humans. More recently, he demonstrated the utility of perfusion imaging using myocardial contrast echocardiography as a diagnostic and prognostic tool in patients with acute coronary syndromes and with chronic coronary disease. Dr. Wei has mentored 8 trainees in the past 10 years.Cardiovascular Medicine faculty members listed elsewhere: Thornburg
Back to Areas of Focus
Grover C. Bagby, MD, is Professor of Medicine and Molecular and Medical Genetics, Founding Director of the OHSU Knight Cancer Institute, past president of the International Society of Experimental Hematology, and currently Associate Editor of Blood. Continuously peer-review funded since 1976 for studies on hematopoiesis and molecular pathogenesis of bone marrow failure, myelodysplastic syndrome, and leukemia, he is a member of the American Society of Clinical Investigation and the Association of American Physicians and chairman of the scientific advisory board of the Fanconi Anemia Research Fund. His current studies focus on the molecular pathogenesis of inherited bone marrow failure syndromes and have revealed the importance of abnormal cytokine production. Currently his laboratory focuses on molecular control points for the toll-like receptor signaling pathway and modulation of the inflammasome with a particular emphasis on tumor necrosis alpha, interleukin 1 and interleukin 18 production. Dr. Bagby's years of experience mentoring T1 researchers will enable him to serve as primary research mentor for trainees with relevant research interests, particularly those with interests in the pathogenesis of shock and cytokine mediated end organ damage, and to serve as a secondary mentor for trainees who will benefit from his expertise in laboratory research, grant-writing, and career development.
Richard T. Maziarz, MD, is Professor of Medicine and Medical Director of OHSU's Adult Stem Cell Transplantation Program and the Center for Hematologic Malignancies. His clinical research focuses on initiatives that can reduce the risks for morbidity and mortality associated with graft versus host disease. His current studies involve the impact of adult stromal stem cell populations on hematopoiesis and graft versus host disease; his findings have been translated to a national study. He also continues to investigate issues of immune deficiency and susceptibility to opportunistic infection. He has been principal or co- investigator on over 50 clinical trials including many investigator-initiated studies. He has mentored many team members including junior faculty, advanced practice providers, and Pharm Ds.
Thomas G. Deloughery, MD, FACP, is a Professor in the Departments of Medicine and Pediatrics (Division of Hematology & Medical Oncology) and the Department of Pathology (Division of Laboratory Medicine). His clinical research interests are in hemostasis and thrombosis, topics of direct relevance for emergency care of ED patients with coagulopathies or bleeding after major trauma. He also has an interest in the hematologic aspects of sport and travel medicine and is Chair of the Research Committee of the Wilderness Medicine Society. He has won numerous teaching awards and has given education sessions to the American Society of Hematology, the American Society of Clinical Oncology, and American College of Rheumatology, American Society of Pediatric Hematology/Oncology and the Society for Critical Care Medicine. In 2001 he was one of two hematologists asked by the NIH to lecture in Vietnam.Back to Areas of Focus
Allison D. Fryer, PhD, is Professor in the Division of Pulmonary & Critical Care Medicine. Dr. Fryer has shown that airway hyperreactivity similar to asthma is accompanied by recruitment of eosinophil inflammatory cells to airway nerves. These eosinophils are activated and release a preformed protein, eosinophil major basic protein, which binds to and blocks M2 muscarinic receptors on nerves. M2 blockade increases neurotransmitter release and increases bronchoconstriction, similar to asthma. Her lab is examining what mechanisms underlie recruitment and activation of eosinophils at the autonomic nerves in the lungs. Her lab is also working to understand how exposure to viral infection, organophosphate pesticides, ozone, or allergens all induce loss of M2 receptor function in the nerves, and the role of eosinophils in the resulting airway hyperreactivity. She has mentored 20 trainees in the past 10 years.
Pulmonary & Critical Care Medicine faculty members listed elsewhere: Jacoby
David H. Ellison, MD, is Professor of Medicine and Chief of the Division of Nephrology & Hypertension. His research addresses the molecular regulation of renal salt excretion and its impact on blood pressure, as well as the pathogenesis and treatment of edema. He has mentored numerous trainees during the past 20 years. He is Associate Director of the OHSU Nephrology T32 training grant and previously served as Associate Director of the OHSU Medical Scientist Training Program. He has supervised MD, PhD and MD/PhD investigators, during the course of their funded research training. In this capacity, he has acted as sponsor for trainees on NRSA grants from NIH, on fellowship grants from AHA, and on K01 and K08 grants through NIH.
Richard J. Mullins, MD, is Professor of Surgery in the Division of Trauma, Critical Care & Acute Care Surgery. From 1992 to 2004, he was supported by a series of grants from the Centers for Disease Control and Prevention, creating OHSU's Rural Trauma System Study Group – a collaboration between Trauma Surgery and EM that led to over 20 publications and motivated the establishment of Oregon's statewide trauma system.
Martin A. Schreiber, MD, is Director of the Division of Trauma, Critical Care & Acute Care Surgery and Chairman of the Committee on Trauma in Oregon. Dr. Schreiber's laboratory, which has been federally funded since 1999, focuses on trauma research related to novel blood products, resuscitation of hemorrhagic shock, early hemorrhage control, and coagulation and inflammatory changes after injury. The laboratory performs clinical, basic science and animal research. Much of this research has combat relevance as Dr. Schreiber is also a Lieutenant Colonel in the US Army Reserve and has been deployed to Iraq and Afghanistan. He mentors between 2 and 5 residents per year in his laboratory. Residents in the laboratory have a long history of giving presentations at national meetings, publishing in high impact journals and winning awards for their research. Many have gone on to successful academic careers in leadership positions. Dr. Schreiber has also mentored PhDs, post-doctoral fellows, clinical fellows, medical students and college students.
Joe Gray, PhD, is a Gordon Moore Endowed Chair, Chair of the Department of Biomedical Engineering, Director of the OHSU Center for Spatial Systems Biomedicine, and Associate Director for Translational Research, OHSU Knight Cancer Institute. The Gray laboratory explores mechanisms by which genomic, transcriptional and proteomic abnormalities occur in selected cancers, elucidates how these abnormalities contribute to cancer pathophysiologies and assesses the ways in which these abnormalities influence responses to gene targeted therapies.
Tamara Hayes, MASc, MSc, PhD, is Assistant Professor in the Division of Biomedical Engineering. She is a biomedical engineer with both industry experience in product development and academic experience in clinical research. Over the past 7 years, her research has focused on developing a new paradigm of care management and clinical research that moves the locus of research from the clinic into the home, where functional behavior can be continuously assessed in a naturalistic setting. She has provided translational research leadership to numerous grants and projects, including a 600-person randomized trial of home-based assessment methods supported by NIA, and a $3 million technology development and evaluation project supported by Intel. She has mentored 7 trainees.
Misha Pavel, PhD, is Professor and Head of the Department of Biomedical Engineering. His research is on multimodal communication systems between humans and machines, analysis and modeling of complex anthropic behaviors including visual and auditory processing, pattern recognition, information fusion and decision making. He develops systems with anthropic abilities for speech and video communication, machine vision, visually guided vehicular control and virtual reality.
Biomedical Engineering faculty members listed elsewhere: Thornburg
Mary M. Heinricher, PhD, is a Professor in the basic science Departments of Behavioral Neuroscience and Physiology & Pharmacology, as well as Vice-Chair for Research in the clinical Department of Neurological Surgery. Her laboratory studies the properties of brainstem modulatory circuits important in the body's defense mechanisms. Her current research focus is understanding how different neuronal classes in the brainstem act in concert as part of the defense response, how these circuits are wired up, and how they are activated under physiological and pathophysiological conditions through bottom-up and top-down mechanisms. She uses a combination of electrophysiology with behavioral testing and pharmacological manipulations to investigate these questions. With her background in pain and pain modulation, her primary focus has been on sensory modulation in the response to external threats and tissue damage. This work is thus highly relevant to trauma. However, in the last several years, she has come to realize that this system is also engaged in the context of internal threats. As a result, her lab is now studying brainstem integrative systems and their role in the response to cerebrovascular events such as subarachnoid hemorrhage and stroke.
John Adelman, PhD, is a Professor in the Departments of Cell & Developmental Biology and of Molecular & Medical Genetics and a Senior Scientist in the Vollum Institute. His laboratory studies the structure, function, and physiological roles of small conductance calcium-activated potassium channels (SK channels) in the brain. To understand the physiological roles of each of the 3 members of the SK channel family, he developed a powerful new approach to transgenic mice and has used homologous recombination to engineer mice in which each of the SK channel genes may be acutely regulated (switched on or off) in vivo, while retaining precise tissue-specific and developmental-specific expression. His lab is currently using these animals to study paradigms of neuronal function and learning and memory pathways, as well as a host of peripheral tissue physiology. Dr. Adelman's research has direct relevance to neuro-protection after cardiac arrest. Dr. Adelman has mentored 14 trainees in the past 10 years.
Kent L. Thornburg, PhD, holds the M. Lowell Edwards Chair in the Department of Medicine. He is Director of the Heart Research Center and Professor of Cardiovascular Medicine, with additional appointments in the Departments of Medicine, Obstetrics & Gynecology, Medical Informatics & Clinical Epidemiology, Biomedical Engineering, and Physiology & Pharmacology. He leads a team of scientists who are studying how mechanical forces alter gene expression in the developing embryo heart. His models are designed to study the roles of shear and wall stresses as signals to developing cardiac structures. His laboratory team also studies fetal heart development and the roles of growth factors and signaling molecules in programming the immature heart and coronary arteries for lifelong vulnerability for disease.
Lowell E. Davis, MD, is Professor in the Heart Research Institute and the Department of Obstetrics & Gynecology Maternal-Fetal Medicine Division. He specializes in maternal heart disease, anemia, hypertension and preterm labor. His research interests include fetal cardiac function and problems of amniotic fluid volume regulation. His background in basic science research includes fetal cardiovascular function and growth of fetal coronary blood vessels during hypoxemia using a model of anemia. Additionally, his interests in the laboratory include the regulation of fetal renal function and amniotic fluid volume. He is former program director for the Oregon BIRCWH K12 program. Dr. Davis has served as the PI of the NICHD Maternal Fetal Medicine Units Network for the Oregon site and has been involved in clinical studies of pregnancy and outcomes.Back to Areas of Focus
Beth A. Habecker, PhD, is Professor of Physiology & Pharmacology and of Anesthesiology & Perioperative Medicine. Her lab researches the changes that occur in cardiac innervation following ischemia reperfusion. She studies the molecular basis for changes in noradrenergic function, investigating the regulation of neuronal proteins that synthesize, store and remove norepinephrine, and the genes that encode them. She is also examining the induction of neuropeptides in the cardiac innervation following infarction, and how those peptides alter neurotransmission and cardiac function. In addition, she is examining the role of neurotrophins in post-infarct denervation and nerve sprouting. She uses a variety of molecular, biochemical, and histological techniques to investigate the regulation of these proteins and genes, using cell lines, primary neuronal cultures, and whole animal studies. She has mentored 8 trainees.
Shaun F. Morrison, PhD, is a Professor of Physiology & Pharmacology and a Senior Scientist in the Division of Neuroscience at OHSU's Oregon National Primate Research Center. His lab uses electrophysiological and anatomical approaches to understand the functional organization, rhythmicities, developmental influences and pharmacology of the CNS circuits that regulate the sympathetic outflows controlling variables critical for homeostasis such as body temperature, energy expenditure, blood glucose, blood pressure, cardiac output, immune function and plasma catecholamines. He is currently pursuing 3 main areas of investigation in the rapidly growing field of autonomic neuroscience. The first concerns the regulation of the sympathetic outflow to brown adipose tissue in the rat as a model system for gaining insight into the central circuits involved in regulating energy metabolism and body temperature. The second is CNS regulation of catecholamine release from the adrenal medulla, an important component of a variety of stress responses including hypoglycemia, hemorrhage, and exercise. The third area of research involves the organization of the medullary pathways regulating sympathetic outflow to the cardiovascular system.
Physiology & Pharmacology faculty members listed elsewhere: Alkayed, Fryer, Heinricher, Thornburg
Daniel M. Hartung, PharmD, MPH, is an Assistant Professor of Pharmacy Practice. He is currently PI and coinvestigator on 2 grants aimed at improving the evidence-based use of prescription medications through medication outreach as well as informing drug policy in the Oregon Medicaid population, and he is supported as a scholar on Dr. Guise's comparative effectiveness research K12. With 7 years at the College of Pharmacy and with his expanding skills as a researcher, Dr. Hartung will be an effective career mentor for trainees from the College of Pharmacy.