Radiology CME Grand Rounds and Visiting Professors
We invite professors from around the country to speak at our institution to enhance our residents and local radiologists knowledge base. Our visiting lecturers can be viewed online via live streaming in case you are unable to join us in person. Our target audience for our lectures are OHSU local and Regional, Primary Care Physicians, Specialty Physicians, Physician Assistants and Nurse Practitioners. CME is available.
Oregon Health & Science University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CreditIf you have any questions or would like to be a speaker please contact Katie Manoogian.
OHSU School of Medicine, Division of CME, designates this live activity for a maximum of 1 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Explore our archive videos of past visiting lecturers. Go to the previous visiting professor lecturers page
Friday February 19th
MR Elastography: New Quantitative Imaging Biomarkers
Friday, February 19th
12:00-1:00 pm Radiology Classroom 10C26
View the recorded session here
This CME Visiting Professor Lecture is Co-sponsored by Diagnostic Radiology and Oregon Radiological Society.
Professor of Radiology
Blanche R. & Richard J. Erlanger Professor of Medical Research
Richard L. Ehman, M.D., is Professor of Radiology at the Mayo Clinic and Emeritus member of the Mayo Board of Trustees. His research program is focused on developing new imaging technologies. He holds more than 40 patents and many of these inventions are widely used in medical care.
He has served as chair of the Radiology and Nuclear Medicine Study Section of the National Institutes of Health (NIH), as a member of the Advisory Council of the National Institute of Biomedical Imaging and Bioengineering of the NIH, and as a member of the Council of Councils of the NIH. Dr. Ehman was awarded the Gold Medal of the International Society for Magnetic Resonance in Medicine in 1995 for his research contributions and the Outstanding Researcher Award of the Radiological Society of North America in 2006. He was elected to the Institute of Medicine of the National Academies of Science in 2010 and named Mayo Clinic Distinguished Investigator in 2014.
Dr. Ehman has served as president of many professional organizations, including the International Society for Magnetic Resonance in Medicine in 2002-03, the academy of Radiology Research in 2012-14, and the Society for Body Computed Tomography and Magnetic Resonance in 2013-14. He currently serves as President- Elect of the Radiological Society of North America (RSNA).
Many disease processes cause profound changes in the mechanical properties of tissues. This accounts for the efficacy of palpation for detecting abnormalities and provides motivation for developing practical methods to quantitatively image tissue elasticity.
Magnetic Resonance Elastography (MRE) is an emerging imaging technique that uses a modified phase-contrast MRI technique to visualize propagating acoustic waves generated by surface drivers, inertial effects, acoustic radiation pressure, or endogenous mechanisms. MRE acquisition sequences are capable of visualizing waves of less a micron in amplitude in vivo. Inversion algorithms are used to process the wave data to generate maps of properties such as stiffness, viscosity, attenuation, and anisotropic behavior, providing access to a new range of previously unexplored tissue imaging biomarkers.
Human studies have demonstrated that it is feasible to quantitatively image the mechanical properties of skeletal muscle, gray and white matter in the brain, thyroid, myocardium, kidney, liver, and skin.
The first established clinical application of the technology is for detection of hepatic fibrosis. Extensive evidence and clinical experience now indicates that MRE is at least as accurate as liver biopsy for this diagnosis, while also being safer, more comfortable, and less expensive. Multiple studies have shown that MRE has higher diagnostic performance than ultrasound-based elastography for diagnosing liver fibrosis, while having a significantly lower technical failure rate.
Emerging evidence suggests that MRE may have an important role for assessing pancreatic disease and specifically for discriminating between mass-forming pancreatitis and malignancy. MRE also shows promise for prediction of pancreatic fistula following pancreatic surgery.
Recent research has suggested that brain stiffness, as measured by MRE, is a novel biomarker of Alzheimer’s disease. Preliminary evidence indicates that brain stiffness may fill a role not addressed by current biomarkers since it is a highly reliable measure that is significantly correlated with measures of functional connectivity.
New research has also shown that MRE-assessed estimates of tumor stiffness are helpful in the preoperative assessment of patients with menigiomas, skull base tumors, and pituitary adenomas.
This presentation will review the rationale and physical basis of MR elastographty and will provide an overview of a range of the emerging applications in bioengineering, mechanobiology, and clinical medicine.
- Describe the rationale for quantitively imaging the mechanical properties of tissue.
- Discuss the basic physical principles of shear wave elastography.
- Describe the emerging clinical applications of MR Elastography.