APOM Lab Research Postdoctoral Fellows
Yingxin Chen, MD
Dr. Chen has been a postdoctoral fellow in our research division since September 2010. He came from the Drum Tower Hospital at Nanjing University Medical School in China where he is a radiologist. He is working with our research team to uncover molecular and cellular mechanisms associated with stroke in order to develop more effective treatments for these patients.
Dr. Chen earned his degree in medical imaging at Xuzhou Medical College followed by a residency in radiology at Shanghai First People Hospital. He then completed a post graduate program in research and applied medicine at The Second Military Medical University in Shanghai. His previous research focused on using imaging techniques for the diagnosis and differential diagnosis of renal cell carcinoma and pancreatic cancer.
When he takes a break from the laboratory, Yingxin enjoys jogging, swimming, and listening to Chinese classical music and American blues.
Mizuko Ikeda, MD, PhD
Dr. Ikeda joined the Anesthesiology and Perioperative Research Division in December 2012. She came from Kyushu University Hospital in Japan where she had been working as an anesthesiologist. She is a postdoctoral fellow under the mentorship of Dr. Koerner and Dr. Hutchens, with her research project involving examining the contribution of neuroinflammation to brain after cardiac arrest and the sexual dimorphism in incidence and outcome of ischemic renal failure. Most experimental work is done with a mouse model of cardiac arrest and cardiopulmonary resuscitation.
Dr. Ikeda earned her medical degree in 2002 at Kyushu University in Fukuoka, Japan. She went on to complete doctoral studies and a residency in anesthesiology at the same University. During her doctoral studies, she was involved in Fukuoka Cohort Study which was a large scale cohort constructed for research and education on lifestyle-related diseases.
When she takes a break from the laboratory, she enjoys reading, swimming, and windsurfing.
Carmen Methner, PhD
Dr. Methner joined Dr. Alkayed's lab as a postdoctoral fellow in January 2014. After earning her PhD from the University of Greifswald, Germany, her first postdoctoral position was in Cambridge, UK, where her research focus was on cardio protective mechanism against ischemia reperfusion injury. During that time she was able to establish an in vivo mouse model of myocardial infarction, which is also allowed investigating chronic heart failure development. This research was partly funded by the European section of the International Society of Heart Research, ISHR-ES/SERVIER Award. Her current research project is focusing on imaging microvascular perfusion and pericytes dynamics after stroke by using two-photon microscopy.
Laura Villasana, PhD
She recently completed her PhD in the Behavioral Neuroscience Program at OHSU in December 2011. Dr. Villasana's dissertation research examined the role of apoE-isoform on the cognitive function of adult female mice following cranial irradiation. Currently, she is a postdoctoral fellow under the mentorship of Dr. Eric Schnell in the APOM Department. Her research project involves examining the integration of new, adult born neurons generated after traumatic brain injury (TBI). It is well established that the rate of constitutive adult neurogenesis is substantially increased after TBI, and it is believed that these newly born neurons integrate into the brain and contribute to cognitive recovery. However, because network integration of new neurons after other types of brain pathology follows an atypical (and possibly dysregulated) pattern, we are interested in studying the maturation and integration of these new neurons after TBI.
Dr. Villasana is also a research trainee, being mentored by Dr. Eric Schnell, MD and senior co-mentor Dr. Nabil Alkayed, MD, PhD.
Jianming Wang, MD
Jianming Wang MD, relocated to Portland from Beijing, China to begin a postdoctoral fellowship in the Research Division in March 2012. In his previous research in APOM Research (2008-2009), he studied in vitro and in vivo model of ischemia to investigate the cellular mechanisms associated with post-ischemic neurogenesis and brain's inflammatory response. Future studies are expected to include the experimental stroke in animal models and the molecular mechanisms in brain's inflammatory response after local ischemia. He earned a medical degree at the Tongji Medical University of Wuhan city, China and was completed residency in department of neurology of Peking Union Medical College Hospital in China and my clinical research focused on cerebrovascular disease as an attending specialist of neurology. He enjoys jogging, travelling and photography.
Wenbin Zhu, MD
Wenbin Zhu MD, who is from Nanjing, China, began working as a postdoctoral fellow in the APOM Research Division in June 2012. He has been a neurological physician for more than 15 years and has now transferred his interests to research on ischemic stroke. In his previous research in APOM Research (2007-2009), he investigated the role of progesterone in isoflurane preconditioning ischemic female mouse brain as well as the neuroprotective effect of dihydrotestosterone to isoflurane preconditioning ischemic male mouse brain. Currenlty, he is will focus on the study of mechanisms of ischemic stroke and the potential for future neuroprotective drugs. He earned a medical degree at the Hunan Medical University in China and completed his residency in the department of neurology at the First Hospital of Changsha in China. When not working he enjoys music, reading, and photography.
Kristen Zuloaga, PhD
Dr. Zuloaga is currently a postdoctoral fellow in Dr. Nabil Alkayed's laboratory. She has a background in both neuroendocrinology and vascular physiology, with a specific interest in sex steroids and their influence on the cerebral vasculature during pathophysiological conditions. As a graduate student, she was supported by a predoctoral fellowship from the American Heart Association to study the effects of androgens on cerebrovascular inflammation induced by endotoxins and cytokines, and following oxygen-glucose deprivation.
Dr. Zuloaga's current project is a logical follow-up to the predoctoral work, and allows her to continue to pursue her interest in the role of sex steroids in cerebrovascular pathophysiology. The goal of her current research is to investigate the role of endothelial specific aromatase in sex-specific endothelial dysfunction following cerebral ischemia.
APOM Research Trainees
Katie Schenning, MD
(Mentor: Michael Hutchens, MD; Senior Co-Mentor: Sharon Anderson, MD) Dr. Schenning completed MD and MPH training at the University of Wisconsin School of Medicine and Public Health before joining our Oregon Scholars Program in 2010. She is currently evaluating mechanisms for protection of the kidney from hypoxic injury. Dr. Schenning was recently selected as a recipient of the 2012 Renal Specialty Award, which recognizes excellence in critical care research. This award was based on her research abstract on the protective effects of hyperglycemia on hypoxic injury in glomerular endothelial cell monolayers that was accepted for oral presentation at the 2012 Society of Critical Care Medicine Meeting. She has also been elected to serve as a member of the ACGME Anesthesiology Residency Review Committee, which defines the rules for training of interns, residents, and fellows in anesthesiology and then assess whether individual programs are in compliance with those rules. Only one resident is chosen amongst the more than 3000 anesthesiology residents in the US to serve on this committee. Dr. Schenning plans to submit a Research Fellowship Grant application to the Foundation for Anesthesia Education and Research (FAER) in 2012.
Ryan Anderson, MD, PhD
Past Trainee- (Mentor: Matthias Merkel, MD, PhD; Senior Co-Mentor: Donna Van Winkle, PhD) Dr. Anderson completed an MD/PhD program at the Duke University School of Medicine before beginning our residency program in 2009. While supported by this training grant, he developed methodology to allow quantification of myocardial ischemia and reperfusion injury in a mouse model using unbiased stereology and demonstrated that this technique had greater efficiency and precision in comparison to conventional planimetry. Dr. Anderson's work led to a first author abstract and poster presentation at the 2011 ASA Annual meeting. He is currently using this methodology to assess the scar formation in mice undergoing temporary occlusion of the left coronary artery as part of a multi-investigator project. Upon completion, the results will be presented at a national meeting and will lead to a co-author manuscript. Dr. Anderson will be starting a cardiothoracic fellowship within our department following completion of his residency training in June 2012.
Ann Bingham, MD
Past Trainee-(Mentor: Matthew Abrahams, MD) Dr. Bingham received her MD from OHSU before beginning her residency training in our department in 2008. While supported by our T32 grant, she performed a meta-analysis of studies identified via a comprehensive systematic search comparing various outcomes of continuous peripheral nerve block catheters with single injection peripheral nerve blocks so as to better clarify and compare the risks and benefits of these procedures. This work led to a first author published abstract and a first author manuscript that is currently under review by Regional Anesthesia and Pain Medicine. She also received a resident travel award for her research abstract entitled "Continuous Peripheral Nerve Block Compared with Single Injection Peripheral Nerve Block: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" that was accepted for poster presentation at the 2011 American Society of Regional Anesthesia Spring Meeting. Dr. Bingham completed her training in June 2011 and is currently engaged in a cardiothoracic anesthesiology fellowship at Columbia University. She is expected to return to OHSU for a faculty position in July 2012.
Nathan Bronson, MD
Past-Trainee(Mentor: James Dolan, MD; Co-Mentor: Jeffrey Kirsch, MD) Dr. Bronson received his MD from the University of California, Davis before beginning a residency in general surgery at OHSU in 2008. He is taking a course in clinical research through the Human Investigators Program at OHSU which offers an integrated and translation research education curriculum. Dr. Bronson is currently completing a study on the effects of pressors on swine gastric conduit as measured by optical fiber spectroscopy that will lead to a first author manuscript. He Bronson is also working on a retrospective review of hiatal hernia following minimally invasive esphogectomy. Dr. Bronson will be moving forward on a clinical study using optical fiber spectroscopy in intra- and post-operative monitoring after low anterior resection (LAR) and other bowel resection to evaluate the effects of epidural in post-LAR patients. His resident research and related activities has so far led to 2 first author and 2 second author abstracts. Dr. Bronson also has grant applications under review by the Oregon Medical Research Foundation and the Society of American Gastrointestinal and Endoscopic Surgeons.
Stacey Fairbanks, MD
Past Trainee-(Mentor: Nabil Alkayed, MD, PhD) Dr. Fairbanks received her MD from the OHSU School of Medicine before beginning our Oregon Scholars Program in 2008. As a medical student, she was involved in research within our department under the supervision of her current resident research mentor, Dr. Nabil Alkayed. Her project examined sex differences between male and female neurons in response to oxygen glucose deprivation, an in vitro ischemia model, and other toxins. Her current research as a resident builds upon this previous research experience and is exploring soluble epoxide hydrolase and epoxyeicosatrienoic acids as a possible mechanism to explain sex differences in neuronal cell death outcomes following cerebral ischemia. Her research and clinical activities has led to 3 first author abstracts, 1 first author and 1 second author publications, 1 first author book chapter, 1 first author manuscript under review, and 3 poster presentations at national meetings. She also received a Research Fellowship Grant from the Foundation for Anesthesia Education and Research (FAER) in 2009 to support her resident research efforts and served as chief resident during her CA3 year. In June 2012, Dr. Fairbanks joined the Anesthesiology faculty at the University of Colorado as an Assistant Professor after the completion of her residency training.
Hoa (Lee-Lee) Nguyen, MD
Past Trainee-(Mentors: Tonya Palermo, PhD and Roger Chou, MD) Dr. Nguyen received an MD from Texas A & M University System HSC College of Medicine before starting our Oregon Scholars Program in 2007. While supported by this training grant, she was involved in comparative effectiveness research evaluating different pain treatment and management modalities. She was also involved with Dr. Chou in developing clinical guidelines for postoperative pain management on behalf of the American Society of Anesthesiology and the American Pain Society. To supplement her clinical research activities, Dr. Nguyen completed a course on systematic reviews through the Human Investigations Program at OHSU. Her resident research and related activities has led to 2 first author abstracts, a co-authored publication in preparation, and 2 poster presentations at national meetings. She also has a first author book chapter on drug interactions in perioperative medicine. Dr. Nguyen received an educational grant from the Foundation for Anesthesia Education and Research and Society of Education in Anesthesia Resident Scholar Program to attend the 2009 ASA Annual Meeting. She also received a scholarship to attend the Fundamentals of Pain Management: Primer for Residents and Fellows course during the 2010 American Pain Society Annual Meeting.
Justin Ortiz, MD
Past Trainee-(Mentor: Paco Herson, PhD) Dr. Ortiz received his MD from the Harvard Medical School in 2002. He then completed a 1 year general surgery internship followed by 2 years in an otolaryngology residency program at the Stanford University Medical Center. Before beginning our Oregon Scholars Program in 2007, Dr. Ortiz was involved with postdoctoral research on behavioral neuropharmacology, cytoarchitecture, circuitry, and electrophysiology of descending modulation of nociception. While supported by this training grant, he examined potential mechanisms by which ischemia altered GABAA receptor sensitivity to various general anesthetics (propofol, etomidate) and sedative/hypnotic drugs (zolpidem, diazepam) used in the clinical practice of anesthesia. This work led to a first author abstract, a co-first authored publication pending review by Neuropharmacology, and a poster presentation at the 2009 American Society of Anesthesiology meeting. Dr. Ortiz completed his training in June 2011 and is currently an Assistant Professor in our department.
Eun Jung Yi, MD
Past Trainee-(Mentor: Julio Gonzalez-Sotomayor, MD) Dr. Yi received her MD from the OHSU School of Medicine before beginning her residency training in our department. During medical school, she was awarded a one year, NIH funded Mentored Medical Student Clinical Research Program Grant via the General Clinical Research Center at OHSU which allowed her to participate in an IRB approved pilot project utilizing functional MRI to monitor changes in brain activity between lean and obese subjects. During her residency, she was involved in a retrospective chart review examining short-term outcomes of peripheral nerve blocks with indwelling catheters. Her work led to a published first author abstract and a poster presentation at the 2011 American Society of Regional Anesthesia Fall Meeting. Dr. Yi completed her residency training in June 2011 and is currently engaged in a Pain Fellowship within our department. As part of her Pain Fellowship, she is involved with research related to lesion sizes of curved radiofrequency probes used in interventional spinal procedures in addition to continuing the retrospective chart review of peripheral nerve block catheters.