OHSU

Publications

Ines Koerner, Assistant Professor

  1. Weinstein JR, Koerner IP, Möller T. Microglia in ischemic brain injury. Future Neurology, 5:227-246, 2010
  2. Herson PS, Koerner IP, Hurn PD: Sex, sex steroids, and brain injury. Semin Reprod Med, 27:229-39, 2009
  3. Koerner IP, Zhang W, Cheng J, Parker S, Hurn PD, Alkayed NJ: Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Frontiers in Bioscience 13:2833-2841; 2008
  4. Vagnerova K, Koerner IP, Hurn PD: Gender and the injured brain. Anesthesia & Analgesia, 107:201-14, 2008     
  5. McCullough LD, Koerner IP, Hurn PD: Chapter 8 Effects of gender and sex steroids on ischemic injury. In Handbook of Clinical Neurology, Vol. 92 (3rd edition). Fisher M (ed.) Elsevier Publishing, 2008        
  6. Koerner IP, Jacks R, Grant DF, DeBarber AE, Koop D, Alkayed NJ: Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. Journal of Neuroscience 27:4642-4649; 2007
  7. Koerner IP and Alkayed NJ: Ischemic preconditioning. In: Acute Stroke: Bench to Bedside, Bhardwaj A (ed), Marcel Dekker New York, 2006
  8. Koerner IP, Murphy SJ, Hurn PD: Gender, Sex Steroids, and Cerebral Ischemic Pathobiology. In Acute Ischemic Injury and Repair in the Nervous System, Vol 23, Handbook of Neurochemistry and Molecular Neurobiology, 3e Chan P (ed). Kluwer Academic/Plenum Publishing, 2005

Top of Page

Michael Hutchens, Assistant Professor

  1. Hutchens MP, Traystman RJ, Fujiyoshi T, Nakayama S, Herson PS.  Normothermic cardiac arrest and cardiopulmonary resuscitation: a mouse model of ischemia-reperfusion injury.  J Vis Exp, accepted, in press
  2. Hutchens MP, Nakano T, Kosaka Y, Dunlap J, Zhang W, Herson PS, Murphy SJ, Anderson S, Hurn PD.  Estrogen is renoprotective via a non-receptor dependent mechanism after cardiac arrest in vivo.  Anesthesiology.2010;112(2)395-405.
  3. Hutchens MP, Nakano T, Dunlap J, Traystman RJ, Hurn PD, Alkayed NJ.  Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation.  Resuscitation. 2008;76(1)89-94
Top of Page

Stephanie Murphy, Associate Professor

Peer-Reviewed

  1. Johnsen D, Murphy SJ. 2011.An in vitro model of isoflurane preconditioning using sex-segregated astrocytes J Neurosurg Anesthesiol 2011, In press.
  2. Ayala P, Uchida M, Cheng J, Ronnekleiv OK, Murphy SJ, Wiren KM, Hurn PD.Androgen Receptor Overexpression Is Neuroprotective In Experimental Stroke.Translational Stroke Research 2011, in press.
  3. Di Domenico F, Casalena G, Sultana R, Cai J, Pierce WM, Perluigi M, Cini C, Baracca A, Solaini G, Lenaz G, Jia J, Dziennis S, Murphy SJ, Alkayed, NJ. Involvement Of STAT3 In Mouse Brain Development And Sexual Dimorphism: A Proteomics Approach. Brain Res 2010, 1362:1-12
  4. Jones RE, Kaler LJ, Murphy SJ, Offner H.Tissue-Dependent Expression of Estrogen Receptor in 17-Estradiol-Mediated Attenuation of Autoimmune CNS Inflammation. Open Autoimmunity Journal 2010, 2:197-204
  5. Zhu W, Wang L, Zhang L, Palmateer JM, Libal NL, Hurn PD, Herson PS, Murphy SJ.Isoflurane Preconditioning Neuroprotection In Experimental Focal Stroke Is Androgen-Dependent In Male Mice.Neuroscience 2010, 169:758-769
  6. Prongay K, Lewis AB, Hurn PD, Murphy SJ.Dietary Soy May Not Confound Acute Experimental Stroke Infarct Volume Outcomes In Ovariectomized Female Rats.Laboratory Animals 2010, 44(3):238-246
  7. Vagnerova K, Liu K, Ardeshiri A, Cheng J, Murphy SJ, Hurn PD, Herson PS.PARP-1 Initiated Neuronal Cell Death Pathway – Do Androgens Matter?Neuroscience 2010, 166(2):476-81
  8. Hutchens MP, Nakano T, Dunlap J, Zhang W, Herson PS, Murphy SJ, Anderson S, Hurn PD.  Estrogen Is Renoprotective Via A Non-Receptor Dependent Mechanism After Cardiac Arrest In Vivo.  Anesthesiology 2010, 112(2):395-405.
  9. Mader SL, Libal NL, Pritchett-Corning K, Yang R, Murphy SJ.Refining Timed Pregnancies In Two Strains Of Genetically Engineered Mice.Lab Animal 2009; 38(9):305-310.
  10. Mito T, Nemoto M,Kwansa H, Sampei K, Habeeb M, Murphy SJ, Bucci E, Koehler RC.Decreased Damage From Transient Focal Cerebral Ischemia By Transfusion Of Zero-Link Hemoglobin Polymers In Mouse.Stroke 2009, 40(1):278-84.
  11. Murphy SJ, Kirsch JR, Zhang W, Grafe M, West AG, del Zoppo GJ, Traystman RJ, Hurn PD. Can Gender Differences Be Evaluated In A Rhesus Macaque (Macaca mulatta) Model Of Focal Cerebral Ischemia?Comp Med.2008, 58(6):588-596.
  12. Wang L, Kitano H, Hurn PD, Murphy SJ.Estradiol Attenuates Isoflurane Preconditioning Neuroprotection In Ischemic Mouse Brain.J Cereb Blood Flow Metab.2008, 28(11):1824-34.
  13. Liu M, Oyarzabal E, Yang R, Murphy SJ, Hurn PD.A Novel Method for Assessing Sex-Specific and Genotype-Specific Response to Injury in Astrocyte Culture.J Neuroscience Methods.2008, 171(2):214-7.
  14. Wang C, Dehghani B, Magrisso IJ, Rick BA, Bonhomme E, Cody DB, Elenich LA, Subramanian S, Murphy SJ, Kelly MJ, Rosenbaum JS, Vandenbark AA, Offner H.GPR30 Contributes to Estrogen-Induced Thymic Atrophy.Molecular Endocrinology.2008; 22(3):636-48.
  15. Kitano H, Young JM, Cheng J, Wang L, Hurn PD, Murphy SJ.Gender-Specific Response To Isoflurane Preconditioning In Focal Cerebral Ischemia.J Cereb Blood Flow Metab.2007; 27(7):1377-1386.
  16. Qui J. Bosch MA, Tobias SC, Graham SM, Murphy SJ, Korach KS, Chambon P, Scanlan TS, Ronnekleiv OK, Kelly MJ.A G Protein-Coupled Estrogen Receptor Is Involved In Hypothalamic Control Of Energy Homeostasis.Journal of Neuroscience.2006; 26(21):5649-5655.
  17. Hickman D, King-Herbert A, Murphy SJ.The Laboratory Animal Board Study Group (LABSG): A Multifaceted Tool for ACLAM Board Preparation.JAALAS.2006; 45(4):33-39.
  18. Joh HD, Searles RV, Selmanoff M, Alkayed NJ, Koehler RC, Hurn PD, Murphy SJ.Estradiol Alters Only GAD67 m RNA Levels In Ischemic Rat Brain With No Consequent Effects On GABA. J Cereb Blood Flow Metab.2006; 26(4);518-526.
  19. Littleton-Kearney MT, Gaines JM, Callahan KP, Murphy SJ, Hurn PD.Effects Of Estrogen On Platelet Reactivity After Transient Forebrain Ischemia In Rats.Biological Research for Nursing.2005; 7(2):135-145.
  20. Singletary SJ, Kirsch AJ, Watson J, Karim BO, Huso DL, Hurn PD, Murphy SJ.Lack Of Correlation Of Vaginal Impedance Measurements With Hormone Levels In The Rat.Contemp Top Lab Anim Sci.2005; 44(6):37-42.
  21. Toung TJ, Chen TY, Littleton-Kearney MT, Hurn PD, Murphy SJ.Effects Of Combined Estrogen And Progesterone On Brain Infarction In Reproductively Senescent Female Rats.J Cereb Blood Flow Metab.2004; 24(10):1160-1166.
  22. Antezana DF, Clatterbuck RE, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, Hurn PD, Traystman RJ, Tamargo RJ.High-Dose Ibuprofen Reduces Striatal Infarcts During Middle Cerebral Artery Occlusion In Rats.J Neurosurg.2003; 98:860-866.
  23. Murphy SJ, Littleton-Kearney MT, Hurn PD.Progesterone Administration During Reperfusion, But Not Preischemia Alone, Reduces Injury In Ovariectomized Rats.J Cereb Blood Flow Metab.2002; 22(10):1181-1188
  24. Kirsch JH, Klaus JA, Blizzard KK, Hurn PD, Murphy SJ.Pain Evaluation And Response To Buprenorphine In Rats Subjected To Sham Middle Cerebral Artery Occlusion.Contemp Top Lab Anim Sci.2002; 41(6):9-14.
  25. Murphy SJ, Smith P, Shaivitz AB, Rossberg MI, Hurn PD.The Effect Of Brief Halothane Anesthesia During Daily Gavage On Complications And Body Weight In Rats.Contemp Top Lab Anim Sci.2001; 40(2):9-12.
  26. Rossberg MI, Murphy SJ, Traystman RJ, Hurn PD.LY 353381.HCl, A Selective Estrogen Receptor Modulator (SERM), And Experimental Stroke.Stroke.2000; 31(12):3041-3046.
  27. Bhardwaj A, Harukuni I, Murphy SJ, Alkayed NJ, Crain BJ, Koehler RC, Kirsch JR, Hurn PD, Traystman RJ.Hypertonic Saline Worsens Infarction Volume After Transient Focal Ischemia In Rats.Stroke.2000; 31:1694-1701.
  28. Murphy SJ, Traystman RJ, Hurn PD.Progesterone Exacerbates Striatal Stroke Injury In Progesterone-Deficient Female Animals.Stroke.2000; 31(5):1173-1178.
  29. Alkayed NJ, Murphy SJ, Traystman RJ, Hurn PD.Neuroprotective Effects Of Female Gonadal Steroids In Reproductively Senescent Female Rats.Stroke.2000; 31:161-168.
  30. O'Malley J, Murphy SJ, Silverman B.Weight Loss And Diarrhea In A Research Dog.Laboratory Animal Science.1999; 49(6):585-587.
  31. Kuo M-F, Song D, Murphy S, Papadopoulos MD, Wilson DF, Pastuszko A.Excitatory Amino Acid Receptor Antagonists Decrease Hypoxia Induced Increase In Extracellular Dopamine In Striatum Of Newborn Piglets.Neurochem Int.1998; 32:281-289.
  32. Jiang K, Kim S, Murphy S, Song D, Pastuszko A.Effect Of Hypoxia And Reoxygenation On Regional Activity Of Nitric Oxide Synthase In Brain Of Newborn Piglets.Neuroscience Letters. 1996; 206:199-203.
  33. Murphy S, Song D, Welsh FA, Wilson DF, Pastuszko A.The Effect Of Hypoxia And Catecholamines On Regional Expression Of Heat-Shock Protein-72 mRNA In Neonatal Piglet Brain.Brain Res.1996; 727:145-152.
  34. Olano M, Song D, Murphy S, Wilson DF, Pastuszko A.Relationships Of Dopamine, Cortical Oxygen Pressure, And Hydroxyl Radicals In Brain Of Newborn Piglets During Hypoxia And Posthypoxic Recovery.J Neurochem.1995; 65(3):1205-1212.
  35. Murphy S, Pastuszko A.Effect Of Neurocatin On The Activity Of Monoamine Oxidase B In Rat Brain Synaptosomes.Neurochemical Research.1994; 19(2):177-182.
  36. Murphy S, Huang C-C, Lajevardi N, Tammela O, Wilson DF, Pastuszko A.Effect Of Hypoxia And Reoxygenation On The Activity Of Transglutaminase In Brain Of Newborn Piglets.Neuroscience Letters. 1994; 172:42-46.
  37. Kesavan P, Mukhopadhayay S, Murphy S, Rengaraju M, Lazar MA, Das M.Thyroid Hormone Decreases The Expression Of Epidermal Growth Factor Receptor.J Biol Chem.1991; 266(16):10282-10286.
  38. Pratt RF, McConnell T, Murphy SJ.Accumulation Of Acyl-Enzyme Intermediates During Turnover Of Penicillins By The Class A -Lactamase Of Staphylococcus aureus PC 1.Biochem J.1988; 254:919-922.


Non-peer-reviewed

  1. Libal N, Mader S, Yang R, Murphy SJ.  2009.  Optimization Of Genetically Engineered Mouse Breeding Colony Management.  OAALAS Observer 9(2):10-11.
  2. Hurn PD, Aardelt AA, Alkayed NJ, Crain BJ, Hu W, Kearney ML, McCullough LD, Murphy SJ, Toung TJK, Traystman RJ, Wang M.Estrogen And Testosterone As Neuroprotectants In Stroke.In Pharmacology of Cerebral Ischemia 2002.Krieglstein J (ed.).Medpharm Scientific Publishers, Stuttgart, Germany, 2002, pp. 17-24.
  3. Hurn PD, NJ Alkayed, A Bhardwaj, RC Koehler, JR Kirsch, MT Littleton-Kearney, LD McCullough, SJ Murphy, MI Rossberg, TJ Toung, RJ Traystman.Cerebral Ischemia: Pathophysiology And Neuroprotection.In Yearbook of Intensive Care and Emergency Medicine: 2001.Vincent JL (ed.).Springer-Verlag Publishing, Heidelberg, 2001.
  4. Murphy SJ, Liu T, Windfuhr M, Song D, Wilson DF, Pastuszko A.Altered Ligand Binding of D1 and D2 Dopamine Receptors In Response To Hypoxia And Posthypoxic Reoxygenation.Adv Exp Med Biol.1999; 471:147-154.
  5. Murphy SJ, Song D, Welsh FA, Wilson DF, Pastuszko A.Regional Expression Of Heat Shock Protein 72 mRNA Following Mild And Severe Hypoxia In Neonatal Piglet Brain. Adv Exp Med Biol.1999; 471:155-163.
  6. Song D, Murphy S, Olano M, Wilson DF, Pastuszko A.Effect Of Hemorrhagic Hypotension On Hydroxyl Radicals In Cat Brain.Adv Exp Med Biol.1998; 454:173-180.
  7. Song D, Murphy SJ, Wilson DF, and Pastuszko A.Response Of Cortical Oxygen And Striatal Dopamine In Newborn Piglets To Alcohol Infusion Under Normoxic And Hypoxic Conditions.Adv Exp Med Biol.1997; 428:197-205.


Chapters

  1. Koerner I, Murphy SJ, Hurn PD.Gender, Sex Steroids, and Cerebral Ischemic Pathobiology.In: Acute Ischemic Injury and Repair in the Nervous System.P Chan (ed).Kluwer Academic/Plenum Publishers.2007, pp. 186-207.
  2. Murphy SJ, Littleton Kearney MT, McCullough LD, Hurn PD.2004.Sex, Hormones and the Endothelium.In:Principles of Sex-Based Differences in Physiology.VM Miller and M Hay (eds). Elsevier Publishing Company: Amsterdam, pp. 71-84


Reviews

  1. Wang L, Traystman RJ, Murphy SJ.Inhalational Anesthetics As Preconditioning Agents In Ischemic Brain.Curr Opin Pharmacol, 2008; 8(1):104-110.
  2. Kitano H, Kirsch JR, Hurn, PD, Murphy SJ.Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents In Ischemic Brain.J Cereb Blood Flow Metab.2007; 27(6):1108-1128.
  3. Graham SM, McCullough, LD, Murphy SJ.Animal Models Of Ischemic Stroke: Balancing Experimental Aims And Animal Care.Comp Med.2004; 54(5):486-496.
  4. Murphy SJ, McCullough LD, Smith JM.Stroke In The Female: Role Of Biological Sex And Estrogen.ILAR J.2004; 45(2):147-159.
  5. Murphy SJ, McCullough LD, Littleton Kearney MT, Hurn PD.Estrogen and Selective Estrogen Receptor Modulators: Neuroprotection After The Women's Health Initiative.Endocrine.2003; 21(1):17-26.

Top of Page

Nabil Alkayed, Professor and Vice Chair

  1. Endothelium-derived hyperpolarizing factor in the brain: influence of sex, vessel size and disease state. Davis CM, Siler DA, Alkayed NJ. Womens Health (Lond Engl). 2011 May;7(3):293-303.
  2. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. J Neurochem. 2011 May;117(4):632-42. doi: 10.1111/j.1471-4159.2010.07139.x. Epub 2011 Jan 24.
  3. In vivo optical imaging of revascularization after brain trauma in mice. Jia Y, Grafe MR, Gruber A, Alkayed NJ, Wang RK. Microvasc Res. 2011 Jan;81(1):73-80. Epub 2010 Nov 12.
  4. Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons. Iliff JJ, Fairbanks SL, Balkowiec A, Alkayed NJ. J Neurochem. 2010 Dec;115(6):1530-42. doi: 10.1111/j.1471-4159.2010.07059.x. Epub 2010 Nov 19.
  5. Involvement of stat3 in mouse brain development and sexual dimorphism: a proteomics approach. Di Domenico F, Casalena G, Sultana R, Cai J, Pierce WM, Perluigi M, Cini C, Baracca A, Solaini G, Lenaz G, Jia J, Dziennis S, Murphy SJ, Alkayed NJ, Butterfield DA. Brain Res. 2010 Nov 29;1362:1-12. Epub 2010 Sep 25.
  6. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC. FASEB J. 2010 Oct;24(10):3770-81. Epub 2010 May 21.
  7. Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. Merkel MJ, Liu L, Cao Z, Packwood W, Young J, Alkayed NJ, Van Winkle DM. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H679-87. Epub 2009 Dec 11.
  8. Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent. Iliff JJ, Alkayed NJ. Future Neurol. 2009 Mar 1;4(2):179-199.
  9. Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo. Jia Y, Alkayed N, Wang RK. J Biomed Opt. 2009 Jul-Aug;14(4):040505.
  10. Epoxyeicosanoid signaling in CNS function and disease. Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ. Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):68-84. Epub 2009 Jun 21. Review.
  11. Mechanisms of gender-linked ischemic brain injury. Liu M, Dziennis S, Hurn PD, Alkayed NJ. Restor Neurol Neurosci. 2009;27(3):163-79. Review.
  12. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia. Zhang W, Iliff JJ, Campbell CJ, Wang RK, Hurn PD, Alkayed NJ. J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. Epub 2009 May 27.
  13. Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. Iliff JJ, Wang R, Zeldin DC, Alkayed NJ. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1352-63. Epub 2009 Mar 20.
  14. Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP). Yang S, Alkayed NJ, Hurn PD, Kirsch JR. Anesth Analg. 2009 Mar;108(3):964-70.
  15. Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Dziennis S, Alkayed NJ. Rev Neurosci. 2008;19(4-5):341-61. Review.
  16. Estrogen inhibits Fas-mediated apoptosis in experimental stroke. Jia J, Guan D, Zhu W, Alkayed NJ, Wang MM, Hua Z, Xu Y. Exp Neurol. 2009 Jan;215(1):48-52. Epub 2008 Oct 7.
  17. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Iliff J, Alkayed NJ, Van Winkle DM. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2128-34. Epub 2008 Oct 3.
  18. Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke. Liu X, Zhang W, Alkayed NJ, Froehner SC, Adams ME, Amiry-Moghaddam M, Ottersen OP, Hurn PD, Bhardwaj A. J Cereb Blood Flow Metab. 2008 Dec;28(12):1898-906. Epub 2008 Jul 23.
  19. In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide. Iliff JJ, Alkayed NJ, Golshani KJ, Weinstein J, Traystman RJ, West GA.
  20. J Cardiovasc Pharmacol. 2008 Jul;52(1):82-9.
  21. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Dziennis S, Yang D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. Environ Health Perspect. 2008 Apr;116(4):474-80.
  22. Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ. Stroke. 2008 Jul;39(7):2073-8. Epub 2008 Mar 27.
  23. Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Koerner IP, Zhang W, Cheng J, Parker S, Hurn PD, Alkayed NJ. Front Biosci. 2008 Jan 1;13:2833-41.
  24. Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation. Hutchens MP, Nakano T, Dunlap J, Traystman RJ, Hurn PD, Alkayed NJ. Resuscitation. 2008 Jan;76(1):89-94. Epub 2007 Aug 28.
  25. A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat. Iliff JJ, Close LN, Selden NR, Alkayed NJ. Exp Physiol. 2007 Jul;92(4):653-8.
  26. Mitochondrial mechanism of neuroprotection by CART. Mao P, Ardeshiri A, Jacks R, Yang S, Hurn PD, Alkayed NJ. Eur J Neurosci. 2007 Aug;26(3):624-32. Epub 2007 Jul 18.
  27. Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. Dziennis S, Jia T, Rønnekleiv OK, Hurn PD, Alkayed NJ. J Neurosci. 2007 Jul 4;27(27):7268-74.
  28. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ. J Neurosci. 2007 Apr 25;27(17):4642-9.
  29. Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2. Yang S, Bhardwaj A, Cheng J, Alkayed NJ, Hurn PD, Kirsch JR. Anesth Analg. 2007 May;104(5):1179-84, tables of contents.
  30. Soluble epoxide hydrolase: a novel therapeutic target in stroke. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. J Cereb Blood Flow Metab. 2007 Dec;27(12):1931-40. Epub 2007 Apr 18.
  31. Deleterious effects of dihydrotestosterone on cerebral ischemic injury. Cheng J, Alkayed NJ, Hurn PD. J Cereb Blood Flow Metab. 2007 Sep;27(9):1553-62. Epub 2007 Feb 21.
  32. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Xu Y, Zhang W, Klaus J, Young J, Koerner I, Sheldahl LC, Hurn PD, Martínez-Murillo F, Alkayed NJ. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14489-94. Epub 2006 Sep 13.
  33. Role of P450 aromatase in sex-specific astrocytic cell death. Liu M, Hurn PD, Roselli CE, Alkayed NJ. J Cereb Blood Flow Metab. 2007 Jan;27(1):135-41. Epub 2006 May 17.
  34. Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA. Joh HD, Searles RV, Selmanoff M, Alkayed NJ, Koehler RC, Hurn PD, Murphy SJ. J Cereb Blood Flow Metab. 2006 Apr;26(4):518-26.
  35. Cocaine- and amphetamine-regulated transcript (CART) peptide: a vasoactive role in the cerebral circulation. Iliff JJ, Alkayed NJ, Gloshani KJ, Traystman RJ, West GA. J Cereb Blood Flow Metab. 2005 Oct;25(10):1376-85.
  36. Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. Liu M, Alkayed NJ. J Cereb Blood Flow Metab. 2005 Aug;25(8):939-48.
  37. Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. Peng X, Zhang C, Alkayed NJ, Harder DR, Koehler RC. J Cereb Blood Flow Metab. 2004 May;24(5):509-17.
  38. High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. Antezana DF, Clatterbuck RE, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, Hurn PD, Traystman RJ, Tamargo RJ. J Neurosurg. 2003 Apr;98(4):860-6.
  39. Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice. Goto S, Sampei K, Alkayed NJ, Doré S, Koehler RC. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R222-30. Epub 2003 Mar 27.
  40. Mechanisms of ischemic brain damage. Bhardwaj A, Alkayed NJ, Kirsch JR, Hurn PD. Curr Cardiol Rep. 2003 Mar;5(2):160-7. Review.
  41. Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H2029-37.
  42. Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD. Stroke. 2002 Jun;33(6):1677-84.

Top of Page

Michael Aziz, Assistant Professor

  1. Insulator-to-Metal Transition in Sulfur-Doped Silicon. Winkler MT, Recht D, Sher MJ, Said    AJ, Mazur E, Aziz MJ. Phys Rev Lett. 2011 Apr 29;106(17):178701. Epub 2011 Apr 25.
  2. Thermal activation and saturation of ion beam sculpting. Hoogerheide DP, George HB, Golovchenko JA, Aziz MJ.
     J Appl Phys. 2011 Apr 1;109(7):74312-743124. Epub 2011 Apr 7.
  3. Molecular dynamics of single-particle impacts predicts phase diagrams for large scale pattern formation. Norris SA, Samela J, Bukonte L, Backman M, Djurabekova F, Nordlund K, Madi CS, Brenner MP, Aziz MJ.
     Nat Commun. 2011;2:276.
  4. Mass redistribution causes the structural richness of ion-irradiated surfaces.
  5.  Madi CS, Anzenberg E, Ludwig KF Jr, Aziz MJ.
     Phys Rev Lett. 2011 Feb 11;106(6):066101. Epub 2011 Feb 8.
  6. The Storz C-MAC video laryngoscope: description of a new device, case report, and brief case series.
  7.  Aziz M, Brambrink A.
     J Clin Anesth. 2011 Mar;23(2):149-52.
  8. Routine clinical practice effectiveness of the Glidescope in difficult airway management: an analysis of 2,004 Glidescope intubations, complications, and failures from two institutions.
  9.  Aziz MF, Healy D, Kheterpal S, Fu RF, Dillman D, Brambrink AM.
     Anesthesiology. 2011 Jan;114(1):34-41
  10. Nanopore fabrication in amorphous Si: Viscous flow model and comparison to experiment.
  11.  George HB, Tang Y, Chen X, Li J, Hutchinson JW, Golovchenko JA, Aziz MJ.
     J Appl Phys. 2010 Jul 1;108(1):14310. Epub 2010 Jul 7.
  12. Evidence-based medicine: ultrasound guidance for truncal blocks.
  13.  Abrahams MS, Horn JL, Noles LM, Aziz MF.
     Reg Anesth Pain Med. 2010 Mar-Apr;35(2 Suppl):S36-42. Review.
  14. Linear dynamics of ion sputtered surfaces: instability, stability and bifurcations.
  15.  Davidovitch B, Aziz MJ, Brenner MP.
     J Phys Condens Matter. 2009 Jun 3;21(22):224019. Epub 2009 May 1
    From crater functions to partial differential equations: a new approach to ion bombardment induced nonequilibrium pattern formation.
  16.  Norris SA, Brenner MP, Aziz MJ.
     J Phys Condens Matter. 2009 Jun 3;21(22):224017. Epub 2009 May
    Linear stability and instability patterns in ion-sputtered silicon.
  17.  Madi CS, Bola George H, Aziz MJ.
     J Phys Condens Matter. 2009 Jun 3;21(22):224010. Epub 2009 May 12.
    Video laryngoscopy with the macintosh video laryngoscope in simulated prehospital scenarios by paramedic students.
  18.  Aziz M, Dillman D, Kirsch JR, Brambrink A.
     Prehosp Emerg Care. 2009 Apr-Jun;13(2):251-5.
  19. Multiple bifurcation types and the linear dynamics of ion sputtered surfaces.
  20.  Madi CS, Davidovitch B, George HB, Norris SA, Brenner MP, Aziz MJ.
     Phys Rev Lett. 2008 Dec 12;101(24):246102. Epub 2008 Dec 9.
  21. Electrochemical acceleration of chemical weathering as an energetically feasible approach to mitigating anthropogenic climate change.
  22.  House KZ, House CH, Schrag DP, Aziz MJ.
     Environ Sci Technol. 2007 Dec 15;41(24):8464-70.
  23. Point defect engineered Si sub-bandgap light-emitting diode.
  24.  Bao J, Tabbal M, Kim T, Charnvanichborikarn S, Williams JS, Aziz MJ, Capasso F.
     Opt Express. 2007 May 28;15(11):6727-33.
  25. Continuum theory of nanostructure decay via a microscale condition.
  26.  Margetis D, Fok PW, Aziz MJ, Stone HA.
     Phys Rev Lett. 2006 Sep 1;97(9):096102. Epub 2006 Sep 1.
  27. Shocks in ion sputtering sharpen steep surface features.
  28. Chen HH, Urquidez OA, Ichim S, Rodriquez LH, Brenner MP, Aziz MJ.
     Science. 2005 Oct 14;310(5746):294-7.
  29. Synthesis of nearly monodisperse embedded nanoparticles by separating nucleation and growth in ion implantation.
  30.  Ramaswamy V, Haynes TE, White CW, MoberlyChan WJ, Roorda S, Aziz MJ.
     Nano Lett. 2005 Feb;5(2):373-7.
  31. Medical pathology in patients with leg ulcers: a study carried out in a leg ulcer clinic in a day hospital for the elderly.
  32.  Schofield M, Aziz M, Bliss MR, Bull RH.
     J Tissue Viability. 2003 Jan;13(1):17-22.

Top of Page

Ansgar Brambrink, MD Professor

  1. Preconditioning and postconditioning for neuroprotection: The most recent evidence.  Fairbanks SL, Brambrink AM. Best Pract Res Clin Anaesthesiol. 2010 Dec;24(4):521-34. Epub 2010 Nov 29.
  2. The Storz C-MAC video laryngoscope: description of a new device, case report, and brief case series.  Aziz M, Brambrink A. J Clin Anesth. 2011 Mar;23(2):149-52.
  3. Routine clinical practice effectiveness of the Glidescope in difficult airway management: an analysis of 2,004 Glidescope intubations, complications, and failures from two institutions.  Aziz MF, Healy D, Kheterpal S, Fu RF, Dillman D, Brambrink AM. Anesthesiology. 2011 Jan;114(1):34-41.
  4. A new name behind the established acronym: society for neuroscience in anesthesiology and critical care.  Brambrink AM. J Neurosurg Anesthesiol. 2010 Jul;22(3):186. No abstract available.
  5. Accreditation and standardization of neuroanesthesia fellowship programs: results of a specialty-wide survey.  Mashour GA, Lauer K, Greenfield ML, Vavilala M, Avitsian R, Kofke A, Koht A, Brambrink A. J Neurosurg Anesthesiol. 2010 Jul;22(3):252-5.
  6. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.  Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW. Anesthesiology. 2010 Apr;112(4):834-41.
  7. "Therapeutic hypercapnia" after ischemic brain injury: is there a potential for neuroprotection?  Brambrink A, Orfanakis A. Anesthesiology. 2010 Feb;112(2):274-6. No abstract available.
  8. Video laryngoscopy with the macintosh video laryngoscope in simulated prehospital scenarios by paramedic students.  Aziz M, Dillman D, Kirsch JR, Brambrink A. Prehosp Emerg Care. 2009 Apr-Jun;13(2):251-5.
  9. Perioperative care of patients with neuromuscular disease and dysfunction.  Brambrink AM, Kirsch JR. Anesthesiol Clin. 2007 Sep;25(3):483-509, viii-ix.
  10. Laser resection of the prostate: implications for anesthesia.  Hanson RA, Zornow MH, Conlin MJ, Brambrink AM. Anesth Analg. 2007 Aug;105(2):475-9. Review.
  11. Induction of cerebral ischemic tolerance by erythromycin preconditioning reprograms the transcriptional response to ischemia and suppresses inflammation.  Koerner IP, Gatting M, Noppens R, Kempski O, Brambrink AM. Anesthesiology. 2007 Mar;106(3):538-47.
  12. Isoflurane is associated with a similar incidence of emergence agitation/delirium as sevoflurane in young children--a randomized controlled study.  Meyer RR, Münster P, Werner C, Brambrink AM. Paediatr Anaesth. 2007 Jan;17(1):56-60.
  13. Management of the paediatric airway: new developments.  Brambrink AM, Meyer RR. Curr Opin Anaesthesiol. 2002 Jun;15(3):329-37
  14. Brain protection by anesthetic agents.  Koerner IP, Brambrink AM. Curr Opin Anaesthesiol. 2006 Oct;19(5):481-6. Review.
  15. Comparison of direct and video-assisted views of the larynx during routine intubation.  Kaplan MB, Hagberg CA, Ward DS, Brambrink A, Chhibber AK, Heidegger T, Lozada L, Ovassapian A, Parsons D, Ramsay J, Wilhelm W, Zwissler B, Gerig HJ, Hofstetter C, Karan S, Kreisler N, Pousman RM, Thierbach A, Wrobel M, Berci G. J Clin Anesth. 2006 Aug;18(5):357-62.
  16. An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia.  Noppens RR, Christ M, Brambrink AM, Koerner IP, Heimann A, Kempski O. Crit Care Med. 2006 Aug;34(8):2194-200.
  17. The antibiotic erythromycin induces tolerance against transient global cerebral ischemia in rats (pharmacologic preconditioning).  Brambrink AM, Koerner IP, Diehl K, Strobel G, Noppens R, Kempski O. Anesthesiology. 2006 Jun;104(6):1208-15.
  18. Airway management in infants and children.  Brambrink AM, Braun U. Best Pract Res Clin Anaesthesiol. 2005 Dec;19(4):675-97. Review.
  19. Fiberoptic techniques.  Koerner IP, Brambrink AM. Best Pract Res Clin Anaesthesiol. 2005 Dec;19(4):611-21. Review.
  20. Traumatic brain injury in children--clinical implications.  Noppens R, Brambrink AM. Exp Toxicol Pathol. 2004 Oct;56(1-2):113-25. Review.
  21. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial.  Seekamp A, van Griensven M, Dhondt E, Diefenbeck M, Demeyer I, Vundelinckx G, Haas N, Schaechinger U, Wolowicka L, Rammelt S, Stroobants J, Marzi I, Brambrink AM, Dziurdzik P, Gasiorowski J, Redl H, Beckert M, Khan-Boluki J. Crit Care Med. 2004 Oct;32(10):2021-8.
  22. Percutaneous dilatation tracheostomy: which technique is the best for the critically ill patient, and how can we gather further scientific evidence?  Brambrink A. Crit Care. 2004 Oct;8(5):319-21. Epub 2004 Sep 8.
  23. Prehospital advanced trauma life support: how should we manage the airway, and who should do it?  Brambrink AM, Koerner IP. Crit Care. 2004 Feb;8(1):3-5. Epub 2003 Dec 29.
  24. Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets.  Golden WC, Brambrink AM, Traystman RJ, Shaffner DH, Martin LJ. Neurochem Res. 2003 Dec;28(12):1883-9.
  25. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia.  Guerguerian AM, Brambrink AM, Traystman RJ, Huganir RL, Martin LJ. Brain Res Mol Brain Res. 2002 Jul 15;104(1):66-80.

Top of Page

Matthias Merkel, Assistant Professor

  1. Synaptic filtering of rate-coded information. Merkel M, Lindner B.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Apr;81(4 Pt 1):041921. Epub 2010 Apr 29.
  2. The role of echocardiography in hemodynamic assessment of septic shock.Griffee MJ, Merkel MJ, Wei KS. Crit Care Clin. 2010 Apr;26(2):365-82, table of contents.
  3. Rationale and design of the FreezeAF trial: a randomized controlled noninferiority trial comparing isolation of the pulmonary veins with the cryoballoon catheter versus open irrigated radiofrequency ablation in patients with paroxysmal atrial fibrillation. Luik A, Merkel M, Hoeren D, Riexinger T, Kieser M, Schmitt C. Am Heart J. 2010 Apr;159(4):555-560.e1.
  4. Persistent atrial fibrillation converts to common type atrial flutter during CFAE ablation. Luik A, Merkel M, Riexinger T, Wondraschek R, Schmitt C.
     Pacing Clin Electrophysiol. 2010 Mar;33(3):304-8. Epub 2009 Dec 16.
  5. Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. Merkel MJ, Liu L, Cao Z, Packwood W, Young J, Alkayed NJ, Van Winkle DM.
     Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H679-87. Epub 2009 Dec 11.
  6. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Iliff J, Alkayed NJ, Van Winkle DM.
     Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2128-34. Epub 2008 Oct 3.
  7. Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes. Merkel MJ, Liu L, Cao Z, Packwood W, Hurn PD, Van Winkle DM. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H409-15. Epub 2008 May 23.
  8. Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt. Cao Z, Liu L, Packwood W, Merkel M, Hurn PD, Van Winkle DM.
     Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H302-10. Epub 2007 Nov 2.

Top of Page