Congratulations to Dr. Nabil Alkayed
Dr. Nabil Alkayed, Professor of Anesthesiology and Perioperative Medicine, has been awarded a 5-year R01 grant from the National Institutes of Aging for his project entitled "Neuroinflammatory mechanisms of aging-related vascular cognitive impairment (VCI)." Dr. Alkayed is an accomplished translational neuroscientist with long standing expertise and interest in the eicosanoid biology and the role of the enzyme soluble epoxidehydrolase in cerebrovascular function and stroke neuroprotection.
The project is based on analysis of postmortem human tissuefrom deceased patients with vascular dementia (VD) which led to the developmentof novel genetic mouse model of VD which is underpinned by the overexpressionthe human gene encoding the protein soluble epoxide hydrolase in vascularendothelial cells. The proposal will use the model to explore the mechanistic underpinning of VD, specifically looking at the role of the peripheral immune system in the development of VD. It is an excellent example of the two-way interplay between basic and clinical research that can lead to novel and clinically-relevant approaches to preventing or treating neurological disease.
Collaborating with Dr. Alkayed on this project will be VA and affiliated APOM researcher Dr. Halina Offner (Co-Investigator) and Department of Behavioral Neuroscience researcher Dr. Jacob Raber.