OHSU

Habecker Lab

Research

We are answering several questions related to physical remodeling of sympathetic neurons after myocardial infarction:

  • What are the molecules and signaling pathways that trigger the loss of nerve fibers adjacent to the infarct?
  • What are the molecules and signaling pathways that cause nerve sprouting and hyperinnervation?
  • Does the aberrant distribution of innervation contribute to arrhythmias?
ventTHir_1

ECGs_1

We are answering several questions related to chemical plasticity of sympathetic neurons:

model

  • Why are the enzymes that make NE high in neuron cell bodies but low in the left ventricle next to the site of tissue damage?
  • What are the transcription factors that mediate inflammatory cytokine effects on the enzymes and transporters important for NE production and removal?
  • Why is the peptide galanin elevated in the heart after myocardial infarction?
  • Does galanin affect sympathetic or parasympathetic transmission in the heart?
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