OHSU

Habecker Lab

Research

We are answering several questions related to physical remodeling of sympathetic neurons after myocardial infarction:

  • What are the molecules and signaling pathways that trigger the loss of nerve fibers adjacent to the infarct?
  • What are the molecules and signaling pathways that cause nerve sprouting and hyperinnervation?
  • Does the aberrant distribution of innervation contribute to arrhythmias?

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We are answering several questions related to chemical plasticity of sympathetic neurons:

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  • Why are the enzymes that make NE high in neuron cell bodies but low in the left ventricle next to the site of tissue damage?
  • Is acetylcholine (ACh) produced in cardiac sympathetic nerves after myocardial infarction?

  • Is sympathetic ACh production triggered by gp130 inflammatory cytokines?
  • What are the functional consequences of sympathetic ACh release in the ventricle?

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