OHSU

Charles E. Roselli, PhD

Chuck 08

Professor of Physiology and Pharmacology

Professor of Anesthesiology

Primary Affiliation

 SOM-Physiology & Pharmacology Department

Program Affiliation

Neuroscience Graduate Program
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences

Background & Education

Ph.D., Hahnemann University, 1981

Research

My research goal is to obtain an integrated understanding of the steroid-sensitive brain circuitry, neurochemical mechanisms, and the subcellular signaling pathways that mediate the central actions of androgens. A major research focus is the characterization of the aromatase-signaling pathway in neural tissue. Aromatase is a cytochrome P450 enzyme (CYP 19) that catalyzes the conversion of testosterone to estradiol. Although androgens and brain-derived estrogens are believed to act coordinately to regulate brain function, the challenge is to understand the complexity of this interaction at a subcellular, cellular, and systems level. A second research direction in my laboratory aims to understand the cellular mechanism(s) by which herbal preparations inhibit prostate growth and to explore their potential as viable treatments for prostate carcinoma.

Roselli Lab cropped SEPT10 002

Research 

Publications

Article: PETA Crosses the Line PETA Crosses the Line

Article:  New York Times January 25, 2007

 

Contact Information

Charles E. Roselli, PhD
Department of Physiology and Pharmacology
Oregon Health & Science University
3181 SW Sam Jackson Park Rd
Portland, OR  97239
Phone: (503) 494-5837
Fax: (503) 494-4352