OHSU

David K. Grandy, PhD

Grandy head shot

Primary Affiliation

Professor - Physiology & Pharmacology Department

Program Affiliation

Physiology & Pharmacology
Neuroscience Graduate Program
Professor of Cell and Developmental Biology
Program in Molecular & Cellular Biosciences

Background & Education

Ph.D. 1985, Michigan State University

Research

I am interested in how neurons communicate with each other. At the molecular level, these cells express an array of proteins that are organized into several complex signaling systems. The system that I have chosen to study is composed of a receptor protein that is coupled to an effector molecule via a GTP-binding protein. The G protein-coupled receptors constitute a large family of molecules that share several structural features yet are diverse with respect to the ligands that they bind and the second messenger systems that they modulate. Taking advantage of the sequence that is conserved between known G protein-coupled receptors, we have employed two strategies which led to the cloning of several dopamine receptors as well as a novel orphan receptor that is homologous to the opioid receptors. We recently discovered the endogenous peptide ligand for this orphan receptor and have demonstrated that one function of orphanin FQ-nociceptin (OFQ-N) is to functionally antagonize the actions of morphine. We are currently using a combination of molecular, cellular, and behavioral approaches to explore the involvement of the dopamine and OFQ-N receptors in the development of opiate tolerance and drug dependence.

Publications

Contact Information


L334/BRB619
Department of Physiology and Pharmacology
Oregon Health & Science University
3181 SW Sam Jackson Park Rd
Portland, OR  97239
Phone: (503) 494-4671
Fax: (503) 494-4352