OHSU

Robert Duvoisin, PhD

Duvoisin MAR 10 007

Primary Affiliation

Professor - Physiology & Pharmacology Department

Program Affiliation

Physiology & Pharmacology, Program in Molecular & Cellular Biosciences
Neuroscience Graduate Program

Background & Education

Ph.D., University of Geneva, Switzerland, 1987

Postdoctoral Fellow, The Salk Institute, La Jolla, CA, 1987-1991

Associate Professor, Cornell University Medical College, New York, NY, 1991-2001

Research

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. In addition to its role in normal brain processes, such as learning and memory, imbalances in glutamatergic function can result in excitotoxic neuronal cell death, epileptic seizures or psychiatric diseases. Glutamate stimulates two classes of receptors: 1) glutamate-gated ion channels, so called ionotropic receptors, which are subdivided into the NMDA, AMPA, and kainate types, and 2) G protein-coupled metabotropic glutamate receptors (mGluRs). Research in the Duvoisin lab is currently focused on group-III mGluRs, a subset of related mGluRs that are selectively activated by L-2-amino-4-phosphonobutyric acid (L-AP4, also abbreviated APB). Group-III mGluRs comprise mGluR4, -R6, -R7, and -R8.

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Publications

Contact Information


L334/BRB609
Department of Physiology and Pharmacology
Oregon Health & Science University
3181 SW Sam Jackson Park Rd
Portland, OR  97239
Phone: (503) 418-2665
Fax: (503) 494-4352