Chemical Tools for Molecular Imaging of Proteins and Pathogens
The overarching goal of The Beatty Group is to develop chemical probes that advance our understanding of microbial pathogenesis and cancer.My group will develop innovative approaches to molecular imaging of various targets, from single proteins to whole organisms. Projects will be inherently multi-disciplinary as my group seeks to reveal pivotal events in disease pathogenesis.
Molecular Imaging with Enzyme Activated Probes
Mycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis (TB).Decades of basic biological and medical research have sought to understand this devastating human disease.Yet we still lack a good understanding of how M. tuberculosis is able to interact successfully with the proteins, organelles, cells, and tissues that make up the human body.The Beatty Group will use approaches from the physical sciences to push the boundaries of what we know about TB.Overall, my group will develop new chemical tools and molecular imaging approaches that will advance our knowledge of mycobacterial biomarkers, infections, and pathogenesis.
Rapid and accurate disease detection could have an enormous impact on diagnosis, treatment, and reducing the spread of TB.My group will create enzyme activated probes to identify biomarkers and develop enzyme-based molecular diagnostics for TB.My group will find enzymes linked to virulence and survival using state-of-the-art chemistry techniques, including activity based profiling and proteomics.Select enzymes will become targets of imaging and diagnostic probe development.Target enzymes might include sulfatases, proteases, or esterases.A long term goal of this project will be to translate novel probes into clinical assays and simple point-of-care diagnostic devices.
Tags for High Resolution Molecular Imaging
Many aspects of human diseases could be elucidated by molecular imaging.Although electron microscopy reveals the greatest molecular-level information about structural organization and protein localization, it is difficult to obtain target-specific contrast.A primary aim of The Beatty Group will be developing new tags for high resolution imaging by correlated light and electron microscopy.Genetically encoded protein tags will be powerful tools for various imaging studies, including elucidating cell signaling pathways or examining tumor microenvironments.
Research projects in my group will require synergistic approaches from many disciplines, including chemistry, microbiology, biochemistry, epidemiology, microscopy, and bioinformatics.Students will develop fluency in a variety of fields and techniques.Graduate students interested in joining the group should contact Prof. Beatty for more information (beattyk [at] ohsu.edu).
The Beatty Lab is recruiting postdoctoral fellows.Please visit the OHSU human resources page to view postings or apply directly by sending a cover letter and CV to Prof. Beatty.