Messer Lab

Dr. Messer's research focuses on dengue virus, a pathogen transmitted by mosquitos and endemic throughout the tropical and sub-tropical world.  His particular interest is in viral genetics and evolution and how those factors affect viral fitness, viral pathogenicity and the human immune response to dengue virus infection.  Dr. Messer's has three areas of active research: 1) vaccine strategies that provide robust cross-protective immunity to dengue infection, 2) the genetic determinants of virus fitness in the mosquito vector Aedes aegypti, and 3) using reverse genetics to identify mutations critical to viral RNA secondary structure and RNA function.