The study of immunology aims to explain how the immune system detects and responds to infection and damage, and yet avoids mounting inappropriate responses against self or other innocuous antigens. Cellular immunologists in the MMI department at OHSU employ rodent and non-human primate models, as well as tissue culture and epidemiologic studies to understand how this careful balance is achieved. Research in the department addresses questions such as how T and B lymphocytes are regulated to prevent autoimmunity and how they collaborate to mount effective immune responses, what intracellular signaling pathways are involved in lymphocyte and innate immune cell responses to danger, and how chronic infections evade elimination by the immune system.