Clinical Laboratory Fellowship Programs
CLINICAL CYTOGENETICS FELLOWSHIP
The OHSU Clinical Cytogenetics Fellowship program is one of three laboratory training programs offered at OHSU, accredited by the American Board of Medical Genetics. It is designed to provide a solid grounding in medical genetics and clinical cytogenetics. The program is open to MD and/or PhD candidates with a sincere interest in medical genetics and clinical cytogenetics. Preference is given to those with a strong genetic background and experience in human cytogenetics. The training objectives are to thoroughly understand all aspects of clinical cytogenetic diagnostic testing including specific methodologies and their application to specific clinical presentations. Fellows rotate through pediatric, adult, prenatal and cancer clinics at OHSU. The laboratory experience, occurring at the OHSU Knight Diagnostic Laboratories, includes hands-on execution of cytogenetic tests including tissue culture, harvesting, slide making, G-banding, karyotyping, fluorescent in situ hybridization (FISH), microscopy, computerized image capturing and array comparative genomic hybridization. The fellow is exposed to clinical laboratory management including lab regulatory issues, quality control procedures, and lab information systems. The fellow learns to communicate test results and their implications to referring physicians and directly to patients. A fellow who successfully completes the training program will be eligible for certification in Clinical Cytogenetics through the American Board of Medical Genetics. The laboratory training is directed by Susan Olson, Ph.D.
CLINICAL BIOCHEMICAL GENETICS FELLOWSHIP
OHSU offers a fully ABMG-accredited training fellowship in Clinical Biochemical Genetics for eligible M.D.'s who have already completed a genetics residency. Fellows receive training in both laboratory diagnosis and clinical management of individuals with inborn errors of metabolism. The training objectives are to thoroughly understand biochemical genetic diagnostic testing including specific methodologies and their application to specific clinical settings and to understand the clinical presentation, etiology, diagnosis, treatment and natural history of inborn errors of metabolism. Trainees will participate in both the Metabolic Clinic at Doernbecher Children's Hospital and in the OHSU Metabolic Consultation Service. The laboratory experience, occurring at the OHSU Knight Diagnostic Laboratories, will include hands-on execution of several biochemical genetic diagnostic tests including amino acid analysis by ion exchange chromatography, organic acid analysis by GC-MS, analysis of carnitine, acylcarnitine profiles and other metabolites by tandem mass spectrometry, and several other qualitative or enzymatic assays. The trainee will learn clinical laboratory management including lab regulatory issues, quality control procedures, and lab information systems. The trainee will also learn to communicate test results and their implications to referring physicians and directly to patients. Additionally, the trainee will learn newborn screening laboratory and clinical follow up practices through our consultative relationship with the Northwest Regional Newborn Screening Program and the Oregon State Newborn Screening Laboratory. A trainee who successfully completes the training program will be eligible for certification in Clinical Biochemical Genetics through the American Board of Medical Genetics. The laboratory training is directed by Cary Harding, M.D.
CLINICAL MOLECULAR DIAGNOSTIC FELLOWSHIP
The training is a two year program in the OHSU Knight Diagnostic Laboratories within the Molecular Diagnostic Center. Fellows learn both technical and reporting components for clinical molecular genetic testing in the laboratory. Technologies within our laboratory include DNA extraction, PCR, melting curve analysis, Southern blotting, oligoligation assays, restriction digestion analysis, Sanger sequencing, allele-discrimination analysis, trinucleotide repeat size analysis, methylation analysis, multiplex-ligation-dependent probe amplification, quantiative PCR, liquid bead array, next generation sequencing, and custom microarray analysis for gene deletions/duplications. Testing includes diagnostic and prenatal diagnostic testing, carrier screening, predictive testing, presymptomatic testing, sex determination, and zygosity determination. The laboratory specializes in rare disorders and cancer tests and is currently developing next generation sequencing panels. The fellow trainee will have the opportunity to develop and validate new clinical tests and participate in research projects. A trainee who successfully completes the training program will be eligible for certification in Clinical Molecular Genetics through the American Board of Medical Genetics. The laboratory training is directed by Sue Richards, PhD.