Susan Olson, PhD - Professor
Oregon Health & Science University
3181 SW Sam Jackson Park Road
Mail Code # MP350
Portland, OR 97239
Office: 503 494-8336
Fax: 503 494-6104
Chromosome aberrations contribute significantly to human disease. Close collaboration between our clinical and research cytogenetics laboratories contributes to a better understanding of specific chromosome regions and chromosome abnormalities, in particular, their structure, origin, segregation, stability, contribution to fetal development and survival, and impact on clinical genetics, including cancer. In collaboration with other laboratories at OHSU, we have a specific focus on the molecular biology of Fanconi anemia, a recessive disorder of DNA repair which has the classic finding of chromosome instability. Investigation of all of the above areas requires utilization of the following state-of-the-art tools: high resolution chromosomes, multiple staining techniques, breakage analysis, sister chromatid exchange assays, metaphase and interphase fluorescent in situ hybridization (FISH) and array comparative genomic hybridization.
Hanlon Newell AE*, Hemphill A*, Akkari YMN, Hejna J, Moses RE, Olson SB: Loss of homologous recombination or non-homologous end-joining leads to radial formation following DNA interstrand crosslink damage. *Co-First Authors. Cytogenet Genome Res, 121:174-180, 2008.
Hejna J, Holtorf M, Hines J, Mathewson L, Hemphill A, Al-Dhalimy M, Olson SB, Moses RE: Tip60 is required for DNA interstrand crosslink repair in the Fanconi anemia pathway. J Biol Chem, 283(15):9844-51, 2008.
Hemphill AW, Bruun D, Thrun L, Akkari Y, Torimaru Y, Hejna K, Jakobs PM, Hejna J, Olson SB, Moses RE: Mammalian SNM1 is required for genome stability. Mol Genet Metab., 94(1):38-45, 2008.
Maslen CL, Babcock D, Redig JK, Kapeli K, Akkari YM, Olson SB: CRELD2:Gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Gene, 382:11-120, 2006.
Sampson JE, Ouhibi N, Lawce H, Patton PE, Battaglia DE, Burry KA, Olson SB. The role for preimplantation genetic diagnosis in balanced translocation carriers. Amer. J. Obstet. Gynecol. 190(6):1707-11, discussion 1711-3, 2004.
Hanlon Newell AE, Akkari YMN, Torimaru Y, Rosenthal A, Reifsteck CA, Cox B, Grompe M, Olson SB: Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes. DNA Repair 3:535-542, 2004.