OHSU

Yuhuang (Daniel) Li, M.D., Ph.D.

Yuhuang Daniel Li

After his medical training in 2007, Dr. Li joined Professor Chaohong Li’s lab in Sun Yat-sen University, China. During his PhD study, Dr. Li focused on molecular and biochemical mechanisms underlying the regulation of MAPKs pathway in multiple pathopoiesis, like metabolic syndrome. Particularly, he has discovered that synergistic MAPKs activation contributes to accelerated vascular remodeling (e.g., atherosclerosis) initiated by hypertension-mechanical stress plus diabetes-AGEs or hyperlipemia-oxLDL or hyperexcitability-norepinephrine. In addition, he participated in the clinical project, collaborated with the First Affiliated Hospital of Sun Yat-sen University, in which survival quality of patients with gastric cancer, risk factors as well as prognostic predictors were explored. They have demonstrated that combined evaluation of centromere protein H and Ki-67 as a valuable prognostic biomarker for patients with gastric carcinoma. In 2012, Dr. Li moved to OHSU and joined Mushui Dai's lab. He is now furthering the field of signaling regulation, including p53 tumor suppression and c-Myc oncogenic pathways.


Selected Publications

Liu S*, Li Y*, Zhang Z, et al. (2013) Alpha1-adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft atherosclerosis. J Vasc Surg. In press. *Authors are equal contribution.

Zhang Z, Zhang M, Li Y, et al. (2013) Simvastatin inhibits the additive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxLDL through LOX-1 pathway. Cell Signal, 2013. 25(1): p. 332-40.

He W.L.*, Li Y.H.*, Yang D.J.*, et al. (2012) Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma. Eur J Surg Oncol. 2012 Sep. doi: 10.1016/j.ejso.2012.08.023. [Epub ahead of print]. *Authors are equal contribution.

Li Y, Liu S, Zhang Z, et al. (2012) RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Increased ERK Activation. PLoS One. 2012;7(4):e35016.