Kishore Challagundla, Ph.D.

Kishore Challagundla

 Kishore did his Masters in Biochemistry from Bharathidasan University (India) in 1999 and was admitted into a PhD program at Lucknow University (India) where he investigated the "Role of free radical induced oxidative stress in modulation of cellular response during argemone oil intoxication" with Prof. Raj Khanna. After completion of his PhD in 2007 he joined at the Division of Infectious Diseases at the Mayo Clinic college of Medicine in Rochester, Minnesota in United States for Post Doctoral studies. Later he moved to Portland (OR) in 2009 to initiate his career in basic cancer biology at Molecular and Medical Genetics in Mushui Dai's lab at OHSU. His research interests in the lab are diverse including the regulation of p53, cMyc turn over by ribosomal proteins. In addition to this he is also exploring the biogenesis pathway of micro RNAs.

He has won several awards including best Paper Published Award in graduate school (2007), Best Poster Presentation Award at the Society for Free Radical Research Asia conference (2007) and two international Fellowships from the European Cell Death Association (ECDO) in 2006 and International Redox Network (IRN) Japan in 2005.

Selected Publications

Sun X.-X., Challagundla K.B., Dai M.-S. (2012) Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J, 31(3): 576-592

Kishore B. Challagundla, Xiao-Xin Sun, Tiffany Devine, Qinghong Zhang, Rosalie C. Sears, Mu-Shui Dai (2011) Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. (Revision Submitted to Molecular & Cellular Biology)

Xiao-Xin Sun, Tiffany DeVine, Kishore B. Challagundla, Mu-Shui Dai. (2011) Interplay between ribosomal protein S27a and MDM2 in p53 activation in response to ribosomal stress.  J Biol Chem 286(26),22730-22741.3.    

Challagundla K Babu, Kannita Suwansrinon, Gary D. Bren, Andrew D. Badley. Stacey A. Rizza. (2009) HIV induces TRAIL sensitivity in hepatocytes. PLOSone, 4(2) e4623.