OHSU

Kei Adachi, Ph.D.

Kei Adachi

During his PhD study at Nagasaki University in Japan, Dr. Adachi studied on the development of AIDS vaccine using influenza virus as a vector and the characteristics of fish nodavirus (Betanodavirus). Particularly, he has discovered that Betanodavirus can replicate in not only fish cell lines but also various mammalian cell lines, but not in human cell lines. In addition, he has also discovered that the post-binding step of Betanodavirus to the cells is inhibited by endocytosis inhibitors, suggesting that Betanodavirus enters the cells by endocytosis pathways. Dr. Adachi has received PhD degree in 2007 from Nagasaki University. Dr.Adachi joined Division of Gene Therapy, Saitama Medical University Research Center for Genomic Medicine in Japan as a postdoctoral fellow and focused on the molecular mechanisms of adenovirus serotype-specific replication. In 2010, Dr. Adachi joined Dr. Hiroyuki Nakai's lab in University of Pittsburgh and started the research on the development and application of Adeno-associated virus (AAV) as a vector for gene therapy. In 2011, Dr. Adachi moved to OHSU with Dr. Nakai and is now focusing on the understanding of AAV capsid structure-phenotype relationships for developing novel AAV vectors with the most desirable biological properties.


Selected Publications

Adachi K and Nakai H. (2011) The role of DNA Repair Pathways in Adeno-associated Virus Infection and Viral Genome Replication/ Recombination/ Integration. DNA Repair and Human Health. Chapter 28: 685-714 2.

Kotchey NM, Adachi K, Nakai H, et al. (2011) A Potential Role of Distinctively Delayed Blood Clearance of Recombinant Adeno-associated Virus Serotype 9 in Robust Cardiac Transduction. Molecular Therapy. 19(6): 1079-1089

Adachi K and Nakai H. (2010) A new recombinant adeno-associated virus (AAV)-based random peptide display library system: Infection-defective AAV1.9-3 as a novel detargeted platform for vector evolution. Gene Therapy and Regulation. 5: 31-55

Adachi K, and Okinaka Y, et al. (2010) Susceptibilities of medaka (Oryzias latipes) cell lines to a betanodavirus. Virology Journal. 7:150-156.

Adachi K and Mitani K. (2009) Insufficient accumulation of viral late mRNAs restricts the replicative cycle of human adenovirus type 37 in A549 cells. Arch Virol. 154(9):  1401-1407

Takizawa N*, Adachi K*, Kobayashi N, et al. (2008) Efficient propagation of betanodavirus in a murine astrocytoma cell line. Virus Research. 136 (1-2): 206-210  *Authors are equal contribution.