Juan Liang, Ph.D.
During her PhD study, Dr. Liang focused on the molecular mechanism of canonical Wnt signaling pathway. She identified a novel protein that could regulate the function of LRP6, the Wnt coreceptor and elucidated the underlying mechanisms. She also studied the function of this protein in embryonic development, using Xenopus embryos as models. After graduation, she went to OHSU and joined Sears' lab in Oct, 2011. Now she is studying the regulation of c-Myc protein stability in human cancers.
Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene. 2011 Aug 8. doi: 10.1038/onc.2011.294. [Epub ahead of print]
Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.
Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W. Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem. 2010 Apr 2;285(14):10890-901.
Qu XH, Wu Q, Liang J, Zou B, Chen GQ. Effect of 3-hydroxyhexanoate content in poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on in vitro growth and differentiation of smooth muscle cells. Biomaterials. 2006 May;27(15):2944-50.
Qu XH, Wu Q, Liang J, Qu X, Wang SG, Chen GQ. Enhanced vascular-related cellular affinity on surface modified copolyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx). Biomaterials. 2005 Dec;26(34):6991-7001.