Ellen Langer, Ph.D.
Oregon Health & Science University
2730 SW Moody Ave
Mail Code: CL4RS
Portland, OR 97201
Dr. Ellen Langer received her Ph.D. from Washington University in St. Louis in 2007. In her doctoral research in the lab of Dr.Gregory Longmore, she identified a role for Ajuba LIM proteins as corepressors of the Snail family of proteins. Using Xenopus neural crest as an in vivo model of epithelial to mesenchymal transitions (EMT), she found that Ajuba LIM proteins are essential for Snail function. Dr. Langer began her postdoctoral research in the labs of Dr. Kenneth Murphy at Washington University and Dr. Mario Capecchi at the University of Utah. There, she studied early fate specification in embryonic stem (ES) cells and found that Snail, which induces an EMT in ES cells, also induces endothelial differentiation. In 2011, Dr. Langer joined the lab of Dr. Rosalie Sears at OHSU where she studies the impact of cell stress and the tumor microenvironment on cancer cell heterogeneity, plasticity, and metastasis. Her current projects include investigating the regulation of vascular mimicry in breast cancer cells and interrogating how tumor microenvironment proteins and cells contribute to tumorigenic phenotypes using 2-dimensional cell culture, mouse modeling, and 3d-bioprinting.
Deverman, BE, Cook, BL, Manson, SR, Niederhoff, RA, Langer, EM, Rosova, I, Kulans, LA, Fu, X, Weinberg, JS, Heinecke, JW, Roth, KA, Weintraub, SJ. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell, 2002, 111(1):51-62.PMID: 12371300.
Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ 3rd. The Ajuba LIM domain protein is a co-repressor for SNAG domain mediated repression and participates in nucleo-cytoplasmic shuttling. Cancer Research, 2007,67(19):9097-106. PMID: 17909014.
Langer EM, Feng Y, Hou Z, Rauscher FJ 3rd, Kroll KL, Longmore GD. Ajuba LIM proteins are Snail corepressors required for Xenopus neural crest development. Developmental Cell, 2008, 14(3): 424-36. PMCID: PMC2279146.
Hou Z, Peng H, Ayyanathan K, Yan K, Langer EM, Longmore GD, Rauscher FJ 3rd. The LIM protein Ajuba recruits protein arginine methyltransferase 5 (PRMT5) to mediate Snail-dependent transcriptional repression. Molecular Cell Biology, 2008, 28(10): 3198-207. PMCID:PMC2423142.
Lindsley RC, Gill JG, Murphy TL, Langer EM,Cai M, Mashayekhi M, Wang W, Niwa N, Nerbonne JM, Kyba M, Murphy KM. Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell,2008, 3(1): 55-68. PMCID: PMC2497439.
Gill JG, Langer EM, Lindsley RC, CaiM, Murphy TL, Kyba M, Murphy KM. Snail and the miR-200 Family Act in Oppositionto Regulate EMT and Germ Layer Fate Restriction in Differentiating ES Cells. StemCells, 2011, 29: 764-776. PMID: 21394833.
Gill JG, Langer EM, Lindsley RC, CaiM, Murphy TL, Murphy KM. Snail promotes the cell-autonomous generation ofFlk1(+) endothelial cells through the repression of the miR-200 family. Stem Cells and Development, 2012, 21(2):167-76. PMID: 21861700.
Cai M, Langer EM, Gill JG, Satpathy AT, Albring JC, K C W, Murphy TL, Murphy KM. Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Blood, 2012, 120(2): 335-46. PMID: 22665933.
Janghorban M, Farrell AS, Allen-Petersen BL, Pelz C, Daniel CJ, Oddo J, Langer EM, Christensen DJ, Sears RC. Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer. ProcNatl Acad Sci U S A, 2014, Jun 24;111(25):9157-62. PMID: 24927563
Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF,Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR. The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene, 2016. PMID:2694701