OHSU

Ellen Langer, Ph.D.

Dr. Langer performed her doctoral research in the lab of Dr. Gregory Longmore at Washington University in St. Louis, where she identified a role for Ajuba LIM proteins as corepressors of the Snail family of proteins.  Through this work, she found that Ajuba LIM proteins are essential for Snail function using Xenopus neural crest as an in vivo model of epithelial to mesenchymal transitions (EMT).  Throughout her graduate studies, Dr. Langer was supported by a Howard Hughes Medical Institute predoctoral fellowship.  Dr. Langer began her postdoctoral research in the lab of Dr. Kenneth Murphy, also at Washington University.  There, she studied early fate specification in embryonic stem (ES) cells.  She found that Snail, which could induce an EMT in ES cells, consistent with modeling cell changes at gastrulation, could also induce endothelial differentiation. In 2010, Dr. Langer joined the lab of Dr. Mario Capecchi at the University of Utah, and in 2011, she joined the lab of Dr. Rosalie Sears at OHSU.  Throughout these transitions, she has continued pursuing the mechanism of Snail-induced endothelium with the support of an American Cancer Society postdoctoral fellowship.  She is currently interested in understanding the implications of this role for Snail in endothelial differentiation in tumor angiogenesis and metastasis.

Selected Publications

Cai M, Langer EM, Gill JG, Satpathy A, Albring J, KC W, Murphy TL, Murphy KM.  Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.  Blood, submitted.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Murphy KM.  Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the miR-200 family.  Stem Cells and Development, 2011.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Kyba M, Murphy KM.  Snail and the miR-200 Family Act in Opposition to Regulate EMT and Germ Layer Fate Restriction in Differentiating ES Cells.  Stem Cells, 2011, 29: 764-776.

Lindsley RC, Gill JG, Murphy TL, Langer EM, Cai M, Mashayekhi M, Wang W, Niwa N, Nerbonne JM, Kyba M, Murphy KM.  Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs.  Cell Stem Cell, 2008, 3(1): 55-68.

Hou Z, Peng H, Ayyanathan K, Yan K, Langer EM, Longmore GD, Rauscher FJ 3rd.  The LIM protein Ajuba recruits protein arginine methyltransferase 5 (PRMT5) to mediate Snail-dependent transcriptional repression.  Molecular Cell Biology, 2008, 28(10): 3198-207.

Langer EM, Feng Y, Hou Z, Rauscher FJ 3rd, Kroll KL, Longmore GD.  Ajuba LIM proteins are Snail corepressors required for Xenopus neural crest development.  Developmental Cell, 2008, 14(3): 424-36. 

Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD and Rauscher FJ 3rd. The Ajuba LIM domain protein is a co-repressor for SNAG domain mediated repression and participates in nucleo-cytoplasmic shuttling. Cancer Research, 2007, 67(19):9097-106.