OHSU

Deanne Tibbitts, Ph.D.

Deanne Tibbitts

Deanne received her PhD from Oregon Health and Science University in September 2011. Working under the direction of Dr. Rosalie Sears, Deanne focused on how the c-Myc oncoprotein is overexpressed in leukemia. Her work has shown that c-Myc is aberrantly stabilized and phosphorylated in acute lymphoblastic leukemia and acute myeloid leukemia. She also studied whether changes in the scaffolding protein Axin1 could underlie aberrant c-Myc protein stabilization in leukemia. As an extension of these studies, she also investigated whether using Axin1 to promote c-Myc degradation in vivo could delay the onset of c-Myc-driven lymphoma. As a graduate student, Deanne was supported by the Training Program in Molecular Hematology and two Tartar Trust fellowships.

Deanne is currently a postdoctoral fellow in the Sears lab, completing the studies begun during her graduate work.


Selected Publications


Arnold HK, Zhang X, Daniel CJ, Tibbitts D, Escamilla-Powers J, Farrell A, Tokarz S, Morgan C, Sears RC. 2009. The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. EMBO Journal 28(5):500-12.

O'neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. 2007. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors. Journal of Experimental Medicine 204(8):1813-24.

Malempati S, Tibbitts D, Cunningham M, Akkari Y, Olson S, Fan G, Sears RC.  2006.  Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias. Leukemia 20(9):1572-81.

Tibbitts D, Rao RR, Shin S, West FD, Stice SL.  2006.  Uniform adherent neural progenitor populations from rhesus embryonic stem cells.  Stem Cells and Development 15(2):200-8.