OHSU

Amy Farrell, Ph.D.

Amy received her BS from the College of William and Mary (Williamsburg, Virginia) in May of 2000.  She then went to the University of Nebraska Medical Center (UNMC) in Omaha to pursue her PhD.  At UNMC, she worked in the laboratory of Dr. Judith Christman where she studied DNA methylation. As a graduate student, Amy was also a representative on the Student Senate, the Graduate Student Association, and the Graduate Student Discipline Hearing Board.  Amy received her PhD degree in Biochemistry and Molecular Biology from UNMC in December of 2006.  She then did a post-doc in the laboratory of Dr. Michel Ouellette at UNMC's Eppley Cancer Institute from January 2007 to May 2008, where she studied the DNA binding promoters of human telomeric proteins.  While in Dr. Ouellette's lab, Amy was funded by an NIH training grant to the Eppley Cancer Institute.  

Amy joined the laboratory of Rosalie Sears at OHSU in June 2008 as a post-doctoral fellow, where she studies the role of the prolyl isomerase Pin1 in the regulation of c-Myc transcriptional activity and oncogenic potential.  She is also interested in the role of c-Myc in pancreatic cancer development and progression, and the development of novel therapies targeting the c-Myc degradation pathway in cancer.  Amy was funded by the Training Grant in Molecular Basis of Skin Pathobiology from June 2008 to May 2010, and received a Collins Medical Trust Research Fellowship for her work in pancreatic cancer in February 2011.  While not in the lab, Amy enjoys spending time with her husband, who is neurosurgery resident at OHSU, and their two children. 

Selected Publications

"The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc." Hugh K Arnold, Xiaoli Zhang, Colin J Daniel, Deanne Tibbitts, Julie Escamilla-Powers, Amy Farrell, Sara Tokarz, Charlie Morgan and Rosalie C Sears.  EMBO Journal (2009) 28:500-512.  

"The tumor suppressor protein HBP1 is a novel c-Myc binding protein that negatively regulates c-Myc's transcriptional activity."  Julienne R. Escamilla-Powers, Colin J. Daniel, Amy Farrell, Karyn Taylor, Xiaoli Zhang, Sarah Byers and Rosalie Sears.  The Journal of Biological Chemistry (2010) 285:4847-4858.

"Deregulated c-Myc phosphorylation and increased protein stability are associated with aberrant Axin1 expression in breast cancer." Xiaoli Zhang, Amy Farrell, Hugh Arnold, Charles Scanlan, Bryan Laraway, Lawrence Lum, Dexi Chen, Megan Troxell & Rosalie C. Sears. In Press, PNAS.

"Characterization of the DNA-binding specificity of Shelterin Complexes." Kyung Choi, Amy Farrell, and Michel Ouellette. In Press, Nucleic Acids Research.

"The Pin1 prolyl isomerase regulates the dynamic interaction of c-Myc with DNA to facilitate c-Myc target gene regulation and oncogenesis." Amy S. Farrell, Colin J. Daniel, Xiaoli Zhang, Xiaoyan Wang, Charlie Morgan, and Rosalie C. Sears. Submitted to Genes and Development.