Holly received her B.S. degree in Micro/Molecular Biology from Portland State University (2012). She is currently in Cheryl Maslen's lab where she is studying one of major consequences of chromosomal aneuploidies, cardiovascular defects/disease. In Down syndrome, atrioventricular septal defect is increased 2000x, while in Turner syndrome, aortic defects and diseases are increased 100x. Using sequencing and medical data, she is identifying genes and mutations that might be disease-causing.This will allow them to predict who will need medical or operative treatment and to identify protein targets to direct drug development. Holly enjoys wakeboarding, soccer, and rock-hunting in her off time.
Michael grew up in the hilly
suburbs of San Francisco, California and studied biology at UC Santa Barbara.
Returning to northern California, Michael completed a masters degree focusing
in molecular endocrinology at the University of San Francisco and briefly
worked in electronic medical devices and web optimization software before
joining OHSU as a graduate student in Molecular and Medical Genetics. Michael
is a member of the Spellman Lab and is interested in understanding the cancer
genome as well as supporting development of computational approaches to
incorporate many types of high dimensional data into fundamental biological
analyses. In addition to his devotion to science, Michael enjoys
competitive cycling and classical guitar.
Ellie is from Monterrey, Mexico and grew up in Brownsville Texas. She received her Bachelors of Science in Biology from The University of Texas at Brownsville in 2010. She came to Portland in the fall of 2011 and joined the PMCB program at OHSU. She is currently a graduate student in the Molecular and Medical Genetics Department and is a member of the McCullough-Lloyd lab. Her current work focuses on the importance of chromatin remodeling for the processing of DNA-protein crosslinks induced by formaldehyde exposure. When not in lab she loves to explore new cuisines and restaurants in and around the Pacific Northwest, and attend all sorts of sporting events.
Asia Mitchell graduated in 2008 from Chatham University, in Pittsburgh, PA, with a Bachelor's of Science in Biochemistry, and subsequently, in 2009, completed a Graduate Certificate in Biomedical Informatics at the University of Pittsburgh. She came to OHSU soon after to work in the lab of Dr. Amanda Vinson, and then began her graduate studies, in 2011, through the Program in Molecular & Cellular Biosciences at OHSU. In June of 2012, Asia joined the lab of Paul Spellman, Ph.D. and is pursuing a degree in Molecular and Medical Genetics. She is currently working on elucidating receptor tyrosine kinase signaling disruption in luminal and basal subtypes of breast cancer. Ultimately, Asia would like to develop a research career focused on personalize or precision medicine within academia.
Brian O'Roak Lab
3rd Year Graduate Student
BS, Stony Brook University
John Powers was born and raised in Beaverton, Oregon. He received his Bachelors of Science in Biology with minors in chemistry and molecular biology from Washington State University in 2011. He is currently a graduate student in the Molecular and Medical Genetics Department. As a member of Dr. Hiroyuki Nakai's lab, his current work focuses on the development of novel adeno-associated virus (AAV) vectors and AAV vector mediated approaches for ocular diseases. His main project aims to identify optimal neuroprotection and gene therapy approaches for inherited eye diseases. When not in lab, John enjoys hiking, camping, and spending time with family and friends.
Daelyn was raised in Sugar Land, TX and moved to the Pacific Northwest when she was a senior in high school. She received her Bachelors of Science with Honors from Portland State University in 2014 and quickly matriculated into the Program of Molecular and Cellular Biosciences here at Oregon Health & Science University. She joined the Harding laboratory in the Medical and Molecular Genetics Department and is passionate about improving therapies for people with rare disorders. She is researching gene therapy for the treatment of phenylketonuria, a rare disorder that affects 1 in 15,000 births, which is currently treated with life-long dietary management. When patients go off diet, they can suffer severe neurological complications. She is also performing research to better understand the mechanism of this neuro-pathophysiology. In her spare time she likes to run marathons and play with her two Labrador retrievers, Dallas and Cordelia Lulu.
Jimi Rosenkrantz received a Bachelors of Science degree in Molecular, Cell & Developmental Biology in 2010 from the University of California, Santa Cruz. After completing her undergraduate studies, Jimi worked as a research technician in the laboratory of Dr. David Haussler. In 2014 she began her graduate studies through the Program in Molecular & Cellular Bioscience at OHSU. In January 2015, she joined the Molecular and Medical Genetics Department as a graduate student in Dr. Lucia Carbone & Dr. ShawnChavez's laboratories. Her current research is focused on investigating the level, mechanism and consequences of somatic aneuploidy and retrotransposon activity in the developing embryo and in the adult brain. Jimi is interested in pursuing a career as an independent researcher focused on better understanding humans and human disease using DNA sequencing technologies and comparative genomic studies, with an ultimate goal of advancing molecular diagnostics and therapeutics options available clinically. In her free time, Jimi enjoys exploring the Pacific Northwest, socializing with friends, and drinking a beer on her front porch with her cat, Jaspurr, by her side.
Lizzyis a native of Cincinnati, OH, and she recently graduated from Cedar Crest College with her BS degree in 2012 as valedictorian of her class. While there, she pursued a major in Genetic Engineering with a minor in Chemistry and a concentration in Forensic Science. Lizzy was also a student athlete playing basketball and being awarded a Second Team Capital One Academic All-American in Division III, a NCAA Postgraduate Scholarship, and the Jostens Trophy. She came to OHSU straight from undergraduate through the Program in Molecular and Cellular Biosciences. In April of 2013, Lizzy joined Doris Kretzschmar's lab, and she is pursuing a doctoral degree in Molecular andMedical Genetics. She is currently working to understand pathways that are involved in neurodegenerative diseases such as Alzheimer's disease. In particular, she is working on understanding how a loss of Neuropathy Target Esterase function leads to Endoplasmic Reticulum stress and how mutations are causing a spectrum of disorders. Ultimately,Lizzy would like to develop a research career that involves clinical diagnostics and teaching at a college level.
Andrew Adey Lab
3rd Year Graduate Student
BS, Eötvös Loránd Tudományegyetem
MS, Eötvös Loránd Tudományegyetem