Open Positions

Postdoctoral Researcher - IRC53937

Monday - Friday, 8:00 am – 5:00 pm; 1.0 FTE; Salary Range: NIH Guidelines; Location: Marquam Hill.
A Postdoctoral Fellow position with a bioinformatics/computational focus is available immediately in the laboratory of Dr. Brian J. O’Roak, Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) for highly motivated individuals. There is an immediate need for a fellow with next-generation sequence analysis experience to lead a project exploring the role of germline mutations and somatic mosaicism in autism and other neurodevelopmental disorders (e.g. neural tube detects), for which funding currently exists—a SFARI funded project. Experience with whole-exome or genome sequencing required. Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics is strongly preferred. Experience with RNA-seq and ChIP-seq is also preferred. Good communication skills are required.

OHSU is a highly collaborative environment. Fellows will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders. Moreover, OHSU has recently signed a unique collaborative agreement with Intel focused on developing the next-generation of computational approaches for human genetics; candidates with interest in this area of research are especially encouraged to apply.

The genetic intractability of complex genetic heterogeneous disorders, such as autism spectrum disorder (ASD), intellectual disability (ID), and broadly defined developmental delay, has been challenged in recent years; first by the application of genomewide platforms to detect copy number and more recently sequencing of the entire protein-coding genome (aka exome). Recent exome sequencing studies of families with simplex or “sporadic” ASD and ID has highlighted the importance of de novo mutations and led to the discovery of novel candidate genes. Moreover, genetic risk has been now shown to span what are generally considered distinct clinical disorders.

Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing. We are building on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies.

Candidates with Ph.D., M.D., or equivalent degrees and intensive training in the areas of genetics/genomics, molecular biology or biochemistry, neuroscience, computer science, bioinformatics are encouraged to apply.

Required Qualifications
  • PhD, MD or MD/PhD in relevant field.
  • Experience with whole-exome or genome sequencing.
  • Good communication skills.

Preferred Qualifications
  • Intensive training in the areas of genetics/genomics, computer science, or bioinformatics.
  • Experience with RNA-seq and ChIP-seq.
  • Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics.

Apply online here and reference job number IRC53937

Bioinformatics Specialist - IRC54045

Schedule Varies; 1.0 FTE; Salary Range: $33,674 - $45,000; Location: Marquam Hill.

This position requires a skilled bioinformaticist with experience processing and analyzing “next-generation” sequencing datasets. Individual will conduct primary and secondary analyzes that will likely require writing custom scripts/programs and running standard best practice computational pipelines in an HT Condor environment. Experience with whole-exome or genome sequencing required. Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics is strongly preferred. Experience with RNA-seq and ChIP-seq is also preferred. Good communication skills are required.

OHSU is a highly collaborative environment. Researchers will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders. Moreover, OHSU has recently signed a unique collaborative agreement with Intel focused on developing the next-generation of computational approaches for human genetics; candidates with interest in this area of research are especially encouraged to apply.

Highlights of Dr. O’Roak’s past research successes include: developing a chromosomal outlier approach to identify candidate genes for Tourette’s syndrome and autism, pioneering trio-based exome sequencing in simplex autism, and developing new technologies for rapid and economical targeted resequencing. We will build on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders.

Required Qualifications

  • Bachelor's Degree with major courses in field of research and 1 to 3 years of experience in computer science or bioinformatics.
  • Fluent in one or more programing languages.

Preferred Qualifications

  • Master's degree in related field.
  • Intensive training in the areas of genetics/genomics, computer science, bioinformatics.
  • Linux cluster management and architecture.

Apply online here and reference job number IRC54045

Research Assistant 2 - IRC53910

Schedule Varies; 1.0 FTE; Salary: $14.73/hour; Location: Marquam Hill.

The role of the position is to study the genetic basis of neurodevelopment disorders, such as autism, in a research group lead by Dr. Brian O'Roak. Bachelor’s degree preferred in Biological Sciences in addition to basic laboratory skills and knowledge of standard molecular biology and cell culturing techniques, such as DNA extraction, cloning, Sanger sequencing, working in tissue culture. Sterile tissue culture technique is required. A strong background in neuroscience, pluripotent stem cell culture, human genetics/genomics, or molecular biology is preferred. Key responsibilities will include supporting studies utilizing induced pluripotent stem cells (iPSCs) and next-generation sequencing to study neurodevelopment. This position demands excellent organizational skills, time flexibility, and the ability to work both independently and in a team environment. 

Required Qualifications

  • Bachelor's Degree with major courses in field of research and No Experience, OR AA and 2 years of relevant experience.
  • Sterile tissue culture technique.
  • Basic laboratory skills and knowledge of standard molecular biology techniques.
  • High level of attention to detail.
  • Proven ability to manage time effectively, especially with competing priorities.
  • Ability to communicate well and work with faculty and staff within the department and University.
  • Ability to take initiative and work independently and in a team environment.
  • Ability to complete tasks in an accurate and timely manner.
  • Some time flexibility.

Preferred Qualifications

  • Bachelor's Degree with major courses in the biological sciences: Neuroscience, Genetics/Genomics, Molecular or Cell Biology.
  • 2-4 years of experience serving on a research team.
  • Experience in an academic research setting, especially with qualitative and/or quantitative methods of data collection.
  • Pluripotent stem cell culture.
  • Human genetics/genomics.
  • Advanced molecular biology.
  • Next-generation library preparation.

Apply online here and reference job number IRC53910