OHSU

Pierre Moenne-Loccoz

Pierre Moenne Loccoz

Email: 
Phone:  503 748-1673
Fax:  503 748-1464
Lab Phone:  503 748-1004

 

Current Appointments

Associate Professor, Division of Environmental and Biomolecular Systems

 

Education

Diplome d'Etudes Approfondies de Biophysique Moleculaire de l'Universite Pierre et Marie Curie Paris VI, 1987
Doctorat de l'Universite Pierre et Marie Curie, Paris VI, 1989

 

Biography

  • University of Oregon, Postdoctoral Research Associate, Department of Chemistry, 1990-92
  • University College London, Department of Biology, 1992-93
  • OHSU/OGI School of Science & Engineering, 1994-95; Research Scientist, 1996-1999; Research Assistant Professor, 1999-2000; Assistant Professor, 2000-2007

 

Research Interests

Structure-function relationships within proteins. Metalloenzymes and hemoproteins. Spectroscopic studies of enzymatic active sites, cofactors, and metal clusters. Reaction intermediates within catalysis. Nitric oxide in bioinorganic chemistry.

 

Selected Publications

Sivaramakrishnan, S.; Ouellet, H.; Matsumura, H.; Guan, S.; Moenne-Loccoz, P.; Burlingame, A. L.; Ortiz, d. M. P. R. (2012) Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion. J. Am. Chem. Soc., 134, 6673-6684. (DOI: 10.1021/ja211499q)

Hayashi, T.; Caranto, J. D.; Matsumura, H.; Kurtz, D. M.; Moenne-Loccoz, P. (2012) Vibrational analysis of mononitrosyl complexes in hemerythrin and flavodiiron proteins: Relevance to detoxifying NO reductase. J. Am. Chem. Soc., 134, 6878-6884. (DOI: 10.1021/ja301812p)

Yukl, E. T.; Ioanoviciu, A.; Sivaramakrishnan, S.; Nakano, M. M.; Ortiz, d. M. P. R.; Moenne-Loccoz, P. (2011) Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis. Biochemistry, 50, 1023-1028. (DOI: 10.1021/bi1015315)

Tran, N. G.; Kalyvas, H.; Skodje, K. M.; Hayashi, T.; Moenne-Loccoz, P.; Callan, P. E.; Shearer, J.; Kirschenbaum, L. J.; Kim, E. (2011) Phenol nitration induced by an {Fe(NO)2}10 dinitrosyl iron complex. J. Am. Chem. Soc., 133, 1184-1187. (DOI: 10.1021/ja108313u)

Hayashi, T.; Miner, K. D.; Yeung, N.; Lin, Y.-W.; Lu, Y.; Moenne-Loccoz, P. (2011) Spectroscopic characterization of mononitrosyl complexes in heme-nonheme diiron centers within the myoglobin scaffold (FebMBs): Relevance to denitrifying no reductase. Biochemistry, 50, 5939-5947. (DOI: 10.1021/bi200409a)

Focke, P. J.; Moenne-Loccoz, P.; Larsson, H. P. (2011) Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate. J. Neurosci., 31, 6255-6262. (DOI: 10.1523/jneurosci.6096-10.2011)

Yukl, E. T.; Jepkorir, G.; Alontaga, A. Y.; Pautsch, L.; Rodriguez, J. C.; Rivera, M.; Moenne-Loccoz, P. (2010) Kinetic and spectroscopic studies of hemin acquisition in the hemophore HasAp from Pseudomonas aeruginosa. Biochemistry, 49, 6646-6654. (DOI: 10.1021/bi100692f)

Namuswe, F.; Hayashi, T.; Jiang, Y.; Kasper, G. D.; Sarjeant, A. A. N.; Moenne-Loccoz, P.; Goldberg, D. P. (2010) Influence of the nitrogen donors on nonheme iron models of superoxide reductase: High-spin FeIII-OOR complexes. J. Am. Chem. Soc., 132, 157-167. (DOI: 10.1021/ja904818z)

Moenne-Loccoz, P.; Fee, J. A. (2010) Catalyzing NO to N2O in the nitrogen cycle. Science (Washington, DC, U. S.), 330, 1632-1633. (DOI: 10.1126/science.1200247)

Kommineni, S.; Yukl, E.; Hayashi, T.; Delepine, J.; Geng, H.; Moenne-Loccoz, P.; Nakano, M. M. (2010) Nitric oxide-sensitive and -insensitive interaction of Bacillus subtilis NsrR with a ResDE-controlled promoter. Mol. Microbiol., 78, 1280-1293. (DOI: 10.1111/j.1365-2958.2010.07407.x)

Jepkorir, G.; Rodriguez, J. C.; Rui, H.; Im, W.; Lovell, S.; Battaile, K. P.; Alontaga, A. Y.; Yukl, E. T.; Moenne-Loccoz, P.; Rivera, M. (2010) Structural, nmr spectroscopic, and computational investigation of hemin loading in the hemophore HasAp from Pseudomonas aeruginosa. J. Am. Chem. Soc., 132, 9857-9872. (DOI: 10.1021/ja103498z)

Hayashi, T.; Caranto, J. D.; Wampler, D. A.; Kurtz, D. M., Jr.; Moenne-Loccoz, P. (2010) Insights into the nitric oxide reductase mechanism of flavodiiron proteins from a flavin-free enzyme. Biochemistry, 49, 7040-7049. (DOI: 10.1021/bi100788y)

Do, L. H.; Hayashi, T.; Moenne-Loccoz, P.; Lippard, S. J. (2010) Carboxylate as the protonation site in (peroxo)diiron(III) model complexes of soluble methane monooxygenase and related diiron proteins. J. Am. Chem. Soc., 132, 1273-1275. (DOI: 10.1021/ja909718f)