Determine the mechanism of pregnancy-associated breast cancer
Distinguishing Indolent from Life-threatening Disease
A second research effort is aimed at developing diagnostic tools to distinguish indolent from lethal breast cancers, as current breast cancer screening triggers a spectrum of potentially unnecessary treatments and psychological distress. This is particularly true for women diagnosed with Ductal Carcinoma in Situ (DCIS). We are investigating the tumor suppressive attributes of the mammary myoepithelial cell using genetically engineered murine models, 3D co-culture models with primary myoepithelial cells, and a human DCIS tissue cohort with available outcomes data.