Working toward breast cancer chemopreventive strategies. See our projects.
The long-term objective of our laboratory research program is to develop breast cancer preventive and therapeutic strategies targeted to specific windows of breast development. The mammary gland is unique in that it can exist in one of several distinct developmental states, such as pubertal or lactational. These distinct “windows of mammary gland development” confer hot spots of risk for breast cancer development and progression, and our lab has identified developmentally regulated stromal-epithelial remodeling programs as the underlying mechanism. While the inherent plasticity of the normal breast microenvironment contributes significantly to breast cancer risk and outcomes, it also provides unique opportunities for life-cycle specific prevention and treatment strategies.