Lisa M. Coussens, Ph.D.

Lisa Coussens

Professor & Chair
Associate Director of Basic Research, Knight Cancer Institute

Office: RJH 5508 | 503 494-7811
Lab: RJH 5508
Coussens Lab
Pubmed Search


1980     Biology, B.A., San Francisco State University
1993     Biological Chemistry, Ph.D., University of California, Los Angeles


1981 – 1988        Research Associate, Molec. & Devel. Biology, Genentech, Inc.
1997 – 1999        Assistant Research Biochemist, Hormone Research Inst., UCSF
1999 – 2004        Assistant Professor (in residence), Dept. of Pathology & Cancer Res. Inst., UCSF
2004 – 2006        Assoc. Professor (in residence), Dept. of Pathology & Cancer Res. Inst., UCSF
2006 – 2007        Associate Professor, Dept. of Pathology & Cancer Research Institute, UCSF
2007 – 2011         Professor, Dept. of Pathology & Cancer Research Institute, UCSF
2007 – 2012         Professor, Dept. of Pathology, UCSF
2011 – Present     Professor & Chair, Cell, Developmental & Cancer Biology, OHSU
2011 – Present     Associate Director for Basic Research, Knight Cancer Institute, OHSU
2012 – Present     Adjunct Professor, University of California, San Francisco

Other Positions Held Concurrently

1989 – 1992         Lecturer, Biology Dept., Whittier College
1992                     Scientific Consultant, Dept. of Legal Affairs. Genentech, Inc.
2000 – 2012         Co-Director, Mouse Pathology Core, Hellen Diller Family Comp. Cancer Center
2007 – 2009         Senior and Deputy Editor, Tumor Microenvironment Section, Cancer Research
2009 – 2012         Co-Leader, Program in Cancer Immunity & Microenvironment. UCSF
2009 – 2012         Deputy Editor, Breaking Advances. Cancer Research

Selected Publications

TH2-polarized CD4+ T cells and macrophages limit efficacy of radiotherapy.
 Shiao S, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. (2015) Can Immuno Res. 3(5):518-525.  PMID: 25716473. Download 

Macrophages and therapeutic resistance in cancer. Ruffell B, Coussens LM. (2015) Cancer Cell. 27(4):462-472. PMID:25828805. Download 

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas. Affara NI, Ruffell B, Medler TR, Gunderson AJ, Johansson M, Bornstein S, Bergsland E, Steinhoff M, Li Y, Gong Q, Ma Y, Wiesen JF, Wong MH, Kulesz-Martin M, Irving B, Coussens LM. (2014) Cancer Cell. 25 (6), 809-21.  Download

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Ruffell B, Affara NI, Cottone L, Junankar, S, Johansson M, DeNardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM. (2013) Genes Dev. 27(19): 2086-2098.  Download

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cells responses to lung adenocarcinoma. Ganessan AP, Johanson M, Ruffell B, Beltran A, Lau J, Jablons DM, Coussens LM.  (2013) J Immunology, 191(4):2009-2017.  Download

B cells and their mediators as targets for therapy in solid tumors. Gunderson AG, Coussens LM (2013) Exp Cell Res. 319, 1644-1649.  Download

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment. Hanahan D, Coussens LM.  (2012) Cancer Cell. 21(3), 309-322. Download

Leukocyte complexity in human breast cancer. Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM. (2012) Proc. Natl. Acad. Sci. 109, 2796-2801. Download

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy. Denardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirström K, West BL, Coussens LM. (2011) Cancer Discov. 1:54-67. Download

FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, Naldini L, de Visser KE, De Palma M, Coussens LM. (2010) Cancer Cell. 17(2):121-34.  Download

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.  DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. (2009) Cancer Cell. 16(2):91-102. Download