OHSU

Thomas Baumann

thomas_baumann
Email: Phone: 503 494-4985
Lab Phone: 503 494-4539
Fax: 503-494-2664

Current Appointments
Adjunct Associate Professor

Office
Robert Jones Hall, Rm #1598
3181 SW Sam Jackson Park Rd, Portland, OR 97239
Mail code: CR-137

Education
Ph.D., Brain Research Institute, University of Zurich, Switzerland, 1983

Research Interests:
sensory neurophysiology, microneurography, patch-clamp, trigeminal, pain, hyperalgesia, ion channels, functional imaging, diabetic neuropathy » PubMed Listing

Summary of Current Research

My laboratory investigates transduction and signaling by somatosensory primary afferent neurons. We use patch clamp recording, immunofluorescence, molecular biology and functional imaging techniques to study ion channels which are responsible for the transduction of chemical, mechanical and thermal stimuli. We also investigate how ion channels are modulated by inflammatory mediators. These studies are important for a better understanding of the cellular mechanisms that are involved in sensory transduction and primary hyperalgesia. In addition, we utilize two approaches for studying peripheral neural mechanisms of chronic pain. One approach focuses upon the biophysical, pharmacological and immunohistochemical characteristics of neurons obtained from diabetic animals and patients treated by ganglionectomy for intractable pain due to nerve injury. A second approach utilizes microneurographic recordings in patients with trigeminal neuralgia or complex regional pain syndrome. These more clinically oriented studies seek to elucidate the cause of abnormal action potential discharge in injured neurons.

Recent Publications

  • Oort PJ, Warden CH, Baumann TK, Knotts TA, Adams SH: Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons. Mol Cell Endocrinol 2007;276:24-35.
  • Baumann TK, Bostock H, Campero M, Ochoa JL: Response of human cold fibers and C-fiber nociceptors to menthol. In Neuroscience 2007. San Diego Convention Center, 2007.Online Abstract Viewer 827.8/KK14
  • Slavin KV, Baumann TK, Burchiel KJ: Treatment of hemiballismus with stereotactic pallidotomy. Case report and review of the literature. Neurosurgical Focus 2004;17:E7.
  • Favre J, Baumann T: Signal Processing and Pattern Recognition in Microelectrode Recordings. in Israel Z, Burchiel KJ (eds): Microelectrode Recording in Movement Disorder Surgery. New York: Thieme, 2004, 100-110.
  • Burchiel KJ, Baumann TK: Pathophysiology of trigeminal neuralgia: new evidence from a trigeminal ganglion intraoperative microneurographic recording. Case report. Journal of Neurosurgery 2004;101:872-873.
  • Baumann TK, Chaudhary P, Martenson ME: Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain. Eur J Neurosci 2004;19:1343-1351.
  • Baumann TK, Burchiel KJ: A method for intraoperative microneurographic recording of unitary activity in the trigeminal ganglion of patients with trigeminal neuralgia. Journal of Neuroscience Methods 2004;132:19-24.