OHSU

Owen McCarty

mccarty

Email:
Phone: 503 418-9307
Fax: 503 418-9311
Alt Phone: 503 418-9350

Current Appointments
Associate Professor, Department of Biomedical Engineering
Associate Professor, Department of Cell & Development Biology

Office
Center for Health and Healing
Mail code: CH13B
3303 SW Bond Avenue, Rm #13033

Education
Ph.D., Chemical & Biomolecular Engineering, Johns Hopkins University, 2002
B.S., Chemical Engineering, State University of New York at Buffalo, 1997

Research Area(s)
Cardiovascular Research
Thrombosis and Hemostasis
Vascular Biology and Vascular Tissue Engineering

Biography
Dr. McCarty received his Ph.D in Chemical & Biomolecular Engineering from Johns Hopkins University with dissertation work focused on the role of platelets in cancer metastasis and thrombosis. As a Wellcome Trust Postdoctoral Fellow, he continued his research in the area of thrombosis, examining the signaling pathways governing platelet cytoskeletal reorganization, at the Department of Pharmacology, Oxford University and Centre for Cardiovascular Sciences, University of Birmingham, UK.

Research Interests
Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.

Selected Publications

  1. McCarty OJ, Mousa SA, Bray PF, Konstantopoulos K. Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions. Blood 2000 Sep; 96(5): 1789-1797.

  2. Abulencia JP, Tien N, McCarty OJ, Plymire D, Mousa SA, Konstantopoulos K. Comparative antiplatelet efficacy of a novel nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis. Arteriosclerosis Thrombosis & Vascular Biology. 2001 Jan; 21(1): 149-156.

  3. Burdick MM, McCarty OJ, Jadhav S, Konstantopoulos K. Cell-cell interactions in inflammation and cancer metastasis. IEEE Engineering in Medicine and Biology 2001 May; 20(3): 86-91.

  4. Mousa SA, Abulencia JP, McCarty OJ, Turner NA, Konstantopoulos K. Comparative efficacy between the GPIIb/IIIa antagonists, roxifiban and orbofiban, in inhibiting platelet function in flow models of thrombosis. Journal of Cardiovascular Pharmacology 2002 Apr; 39(4): 552-5560.

  5. McCarty OJ, Jadhav S, Burdick MM, Bell WR, Konstantopoulos K. Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells. Biophysical Journal 2002 Aug; 83(2): 836-48.

  6. McCarty OJ, Tien N, Bochner BS, Konstantopoulos K. Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to Platelets in shear flow. American Journal of Physiology: Cell Physiology 2003 May; 284(5): C1223-34.

  7. Hanley W†, McCarty OJ†, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K. Single-molecule characterization of P-selectin/ligand binding. Journal of Biological Chemistry 2003 Mar; 278(12): 10556-61. †equally contributing first authors.

  8. McCarty OJ, Abulencia JP, Mousa SA, Konstantopoulos K. Evaluation of platelet antagonists in in-vitro flow models of thrombosis. Methods of Molecular Medicine 2004 Aug; 93: 21-34.

  9. McCarty OJ, Zhao Y, Andrew N, Machesky LM, Staunton D, Frampton J, Watson SP. Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion. Journal of Thrombosis and Haemostasis 2004 Oct; 2(10): 1823-1833. (Paper of the year).

  10. Ahn KC, Jun A*, Pawar P, Jadhav S, Napier S, McCarty OJ, Konstantopoulos K. Preferential binding of Platelets to monocytes over neutrophils under flow. Biochemical and Biophysical Research Communications 2005 Apr; 329(1): 345-355.

  11. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin αIIbβ3 signaling in Platelets. Journal of Thrombosis and Haemostasis 2005 Aug; 3(8): 1752-62.

  12. McCarty OJ, Larson M, Auger JM, Atkinson BT, Kalia N, Pearce AC, Ruf S, Henderson, Tybulewicz V, Machesky LM, Watson SP. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. Journal of Biological Chemistry 2005 Nov; 280(47): 39474-39484.
  13. Inoue O, Suzuki-Inoue K, McCarty OJ, Moroi M, Ruggeri ZM, Kunicki TJ, Ozaki Y, Watson SP. Laminin stimulates spreading of Platelets through integrin α6β1-dependent activation of GPVI. Blood 2006 Feb; 107(4): 1405-12.

  14. McCarty OJ, Calaminus SD, Berndt MC, Machesky LM, Watson SP. VWF mediates platelet spreading through GPIb and αIIbβ3 in the presence of botrocetin and ristocetin, respectively. Journal of Thrombosis and Haemostasis 2006 Jun; 4(6): 1367-78.

  15. Thornber K, McCarty OJ, Watson SP, Pears CJ. Distinct but critical roles for integrin αIIbβ3 in platelet spreading on fibrinogen, collagen-related peptide and thrombin. FEBS Journal 2006 Nov; 273(22): 5032-5043. (Cover)

  16. Pearce AC, McCarty OJ, Calaminus SDJ, Vigorito E, Turner M, Watson SP. Vav family proteins are required for optimal regulation of the PLCγ2 by integrin αIIbβ3. Biochemical Journal 2007; 401: 753-761.

  17. Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP. GPVI-potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb & Vasc Biol. 2007; 27:422-429.

  18. Dhanjal TS, Ross EA, Auger JM, McCarty OJ, Hughes CE, Senis YA, Buckley CD, Watson SP. Minimal regulation of platelet activity by PECAM-1. Platelets 2007 Feb; 18(1): 56-67.

  19. Calaminus SD†, McCarty OJ†, Auger JM, Insall RH, Watson SP, Machesky LM. A major role for Scar/WAVE-1 downstream of GPVI in platelets. Journal of Thrombosis and Haemostasis 2007 Mar; 5(3): 537-43. †equally contributing first authors
  20. White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. The leech product saratin is a potent inhibitor of platelet integrin α2β1 and von Willebrand factor binding to collagen. FEBS Journal 2007 Mar; 274(6): 1481-1492.

  21. Gruber A, Marzec U, Bush L, Di Cera E, Fernandez JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. Relative antithrombotic and antihemostatic effects of protein C activator versus low molecular weight heparin in primates. Blood 2007 May; 109(9): 3733-40.

  22. Calaminus SDJ, Auger JM, McCarty OJ, Wakelam MJO, Machesky LM, Watson SP. MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. Journal of Thrombosis and Haemostasis 2007 Oct; 5(10): 2136-45. (Paper of the year)

  23. Berny MA, White TC, Tucker EI, Bush-Pelc LA, Di Cera E, Gruber A, McCarty OJ. The thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arteriosclerosis Thrombosis & Vascular Biology. 2008 Feb;28(2):329-34. (Featured article with Editorial)

  24. Markway BD, McCarty OJ, Marzec UM, Courtman DW, Hanson SR, Hinds MT. Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain antibody. Tissue Engineering Part C 2008 Jun; 14(2):97-105. (In Focus article)

  25. White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernandez JA, Griffin JH, Gruber A, McCarty OJ. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2'. Journal of Thrombosis and Haemostasis 2008 Jun; 6(6): 995-1002. (Cover)

  26. Calaminus SDJ, Thomas S, McCarty OJ, Machesky LM, Watson SP. Identification of a novel, actin-rich structure, the actin nodule, in the early stage of platelet spreading. Journal of Thrombosis and Haemostasis 2008 Nov; 6(11):1944-52.

  27. Lovely RS, Rein CM, White TC, Jouihan SA, Boshkov LK, Bakke AC, McCarty OJ, Farrell DH. γA/γ' fibrinogen inhibits thrombin-induced platelet aggregation. Thrombosis and Haemostasis 2008 Nov; 100(5):837-846.

  28. Yang XV, Banerjee Y, Fernandez JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proceedings of the National Academy of Science 2009 Jan; 106(1): 274-279.

  29. Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn M, Bennett JS, DeGrado WF. Small molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Science 2009 Jan; 106(3): 719-724.

  30. Tucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR. Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood 2009 Jan; 113(4): 936-944.

  31. Scholl B, Liu HY, Long BR, McCarty OJ, O'Hare T, Druker, BJ, Vu TQ. Single Particle quantum dot imaging achieves ultrasensitive detection capabilities for western immunoblot analysis. American Chemical Society Nano 2009 Jun 23;3(6):1318-28.

  32. White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arteriosclerosis Thrombosis & Vascular Biology. 2009 Oct; 29(10): 1602-7. (Featured article with Editorial)

  33. Vartanian KB, Kirkpatrick SJ, McCarty OJ, Vu TQ, Hanson SR, Hinds MT. Progenitor and carotid endothelial cells elongated on micropatterned surfaces exhibit distinct and shape-dependent extracellular matrix microenvironments. Journal of Biomedical Materials Research Part A 2009 Nov; 91A(2): 528-539.

  34. Eshel-Green T, Berny MA, Conley RB, McCarty OJ. Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow. Thrombosis and Haemostasis 2009 Nov; 102(5): 958-65
  35. Vartanian KB, Berny MA, McCarty OJ, Hanson SR, Hinds MT. Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress. American Journal of Physiology: Cell Physiology 2010 Feb; 298(2):C333-41.

  36. Berny MA, Munnix ICA, Auger JM, Schols SEM, Cosemans JMEM, Panizzi P, Bock PE, Watson SP, McCarty OJ†, Heemskerk JWM†. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS ONE 2010 Apr; 5(4): e10415(1-8). †equally contributing senior authors.

  37. Berny MA, Patel IA, White-Adams TC, Simonson P, Gruber A, Rugonyi S, McCarty OJ. Rational design of an ex vivo model of thrombosis. Cellular and Molecular Bioengineering 2010 Jun; 3(2): 187-189.

  38. White-Adams TC, Berny MA, Patel IA, Tucker EI, Gailani D, Gruber A, McCarty OJ. Laminin promotes coagulation and thrombus formation in a FXII-dependent manner. Journal of Thrombosis and Haemostasis 2010 Jun; 8(6):1295-301.

  39. Tucker EI, Marzec UM, Berny MA, Hurst S, Bunting S, McCarty OJ, Gruber A, Hanson SR. Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Science Translational Medicine 2010 Jun; 2(37): 37ra45.

  40. Sinha S, Miller L, Subramanian S, McCarty OJ, Proctor T, Meza-Romero R, Burrows GG, Vandenbark AA, Offner H. Binding of recombinant T cell receptor ligands (RTL) to APC prevents upregulation of CD11b and Ly6c and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2010 Aug 25;225(1-2):52-61.

  41. McCarty OJ, Conley RB, Shentu W, Tormoen GW, Zha D, Xie A, Qi Y, Zhao Y, Carr C, Belcik T, Keene DR, de Groot PG, Lindner JR. Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. JACC Cardiovascular Imaging 2010 Sep; 3; 947-955. (with Editorial)

  42. Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun M, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renne T, Gruber A, Gailani D. A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood 2010 Nov; 116(19): 3981-9.

  43. Itakura A, Aslan JE, Sinha S, White-Adams TC, Patel IA, Vandenbark AA, Burrows GG, Offner H, McCarty OJ. Characterization of human platelet binding of recombinant T-cell receptor ligand. Journal of Neuroinflammation 2010 Nov 8;7:75.

  44. Berny-Lang MA, Aslan JE, Tormoen GW, Patel IA, Bock PE, Gruber A, McCarty OJ. Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells. Physical Biology 2011 Feb 7; 8(1): 015014.

  45. Berny-Lang MA, Hurst S, Tucker EI, Pelc LA, Wang RK, Hurn PD, Di Cera E, McCarty OJ, Gruber A. Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke 2011 Jun; 42(6):1736-41.

  46. Aslan JE, Spencer AM, Loren CP, Pang J, Welch HC, Greenberg DL, McCarty OJ. Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in Platelets. Journal of Molecular Signaling 2011 Sep; 6(1):11.

  47. Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood 2011 Sep; 118(11):3129-36. (Cover)

  48. Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ. Activated factor XI stimulates neutrophil oxidative burst and inhibits chemotaxis. Journal of Leukocyte Biology 2011 Nov; 90 (5):923-927.

  49. Tormoen GW, Rugonyi S, Gruber A, McCarty OJ. Role of carrier number on the procoagulant activity of tissue factor in blood and plasma. Physical Biology 2011 Dec; 8(6): 066005.