OHSU

Nicholas Wang

Email:
Phone: 503 494-4943
Fax: 503 418-9311

Current Appointment
Research Assistant Professor

Office
Biomedical Research Building, Rm #519
Mail Code: L346JG
3181 SW Sam Jackson Park Rd., Portland, OR 97239

Education
Ph.D., University of California, Los Angeles
Postdoctoral Fellow, Lawrence Berkeley National Laboratory

Research Areas
OHSU Center for Spatial System Biomedicine

Research Interests
Dr. Wang is focused on identifying mechanisms of drug sensitivity and resistance in breast cancer for a large panel of FDA approved drugs using the latest sequencing technologies. His work has centered on the development of next-generation sequencing as a research tool for identification of biomarkers of drug response.

Selected Publications
  • Heiser, L.M., Sadanandam, A., Kuo, W.L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Wooster, R.F., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc. Natl. Acad. Sci. USA. 109(8):2724-2729. PMC3286973.
  • Wang, N.J., Sanborn, Z., Arnett, K.L., Bayston, L.J., Liao, W., Proby, C.M., Leigh, I.M., Collisson, E.A., Gordon, P.B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J.P., Vemula, S.S., Mauro, T.M., Neuhaus, I.M., Leboit, P.E., Hur, J.S., Park, K., Huh, N., Kwok, P.Y., Arron, S.T., Massion, P.P., Bale, A.E., Haussler, D., Cleaver, J.E., Gray, J.W., Spellman, P.T., South, A.P., Aster, J.C., Blacklow, S.C., Cho, R.J. (2011) Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc. Natl. Acad. Sci. USA. 108(43):17761-6. PMC3203814.
  • Durinck, S., Ho, C., Wang, N.J., Liao, W., Jakkula, L.R., Collisson, E.A., Pons, J., Chan, S.-W., Lam, E.T., Chu, C., Park, K., Hong, S.-W., Hur, J.S., Huh, N., Neuhaus, I.M., Yu, S.S., Grekin, R.T., Mauro, T.M., Cleaver, J.E., Kwok, P.-Y., LeBoit, P.E., Getz, G., Cibulskis, K., Aster, J.C., Huang, H., Purdom, E., Li, J., Bolund, L., Arron, S.T., Gray, J.W., Spellman, P.T., Cho, R.J. (2011) Temporal dissection of tumorigenesis in primary cancers. Cancer Discovery, 1:137-143. PMC3187561.
  • Lapuk, A., Marr, H., Jakkula, L., Pedro, H., Bhattacharya, S., Purdom, E., Hu, Z., Simpson, K., Pachter, L., Durinck, S., Wang, N., Parvin, B., Fontenay, G., Speed, T., Garbe, J., Stampfer, M., Bayandorian, H., Dorton, S., Clark, T.A., Schweitzer, A., Wyrobek, A., Feiler, H., Spellman, P., Conboy, J., Gray, J.W. (2010) Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol. Cancer Res., 8(7): 961-74. PMC2911965.
  • Kuo, W.-L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W.J., Heiser, L.M., Sadanandam, A., Fontenay, G.V., Hu, Z., Wang, N.J., Bayani, N., Feiler, H.S., Neve, R.M., Wyrobek, A.J., Spellman, P.T., Marton, L.J. Gray, J.W. (2009) A systems analysis of chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med., 7:77. PMC2803786.