OHSU

John Muschler

John Muschler_web
Email:
Phone: 503 494-0519
Fax: 503 494-3688

Current Appointment
Research Associate Professor

Office
Collaborative Life Sciences Building (CLSB)
Mail Code: CL3G
2730 SW Moody Avenue, Portland, OR 97201

Education
Ph.D., University of Illinois
Postdoctoral Fellow, Pasteur Institute
Postdoctoral Fellow, Lawrence Berkeley National Laboratory

Research Area
OHSU Center for Spatial Systems Biomedicine

Research Interests
My research has focused on ECM receptor signaling in the context of normal cell biology and human disease, and the generation of unique reagents and methods for the dissection of these pathways.

Selected Publications
  • Akhavan, A., Griffith, O.L., Soroceanu, L., Leonoudakis, D., Luciani-Torres, M.G., Daemen, A., Gray, J.W., Muschler, J.L. (2012) Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes. Cancer Res. 72(10):2578-88.
  • Leonoudakis, D., Singh, M., Mohajer, R., Mohajer, P., Fata, J.E., Campbell, K.P., Muschler, J.L. (2010). Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity. J. Cell Science.
  • Beliveau, A., Mott, J.D., Lo., A, Chen, E.I.2, Koller, A.A., Yaswen, P., Muschler, J.L. and Bissell, M.J. (2010) Raf-induced MMP9 Disrupts Tissue Architecture of Human Breast Cells in Three-Dimensional Culture and is Necessary for Tumor Growth in vivo. Genes and Development 24:2800-11.
  • Muschler, J.L., Streuli, C.H. (2010). Cell-matrix interactions in mammary gland development and breast cancer. In Mammary Gland Biology. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a003202.
  • Xu, R., Nelson, C.M., Muschler, J.L., Veiseh, M., Vonderhaar, B.K., Bissell, M.J. (2009). Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biology. 184:57-66.