OHSU

Heidi Feiler

Heidi Feiler

Email: Phone: 503 494-7707
Fax: 503 346-6971

Current Appointments
Research Associate Professor
Deputy Director, OHSU Center for Spatial Systems Biomedicine

Office
Collaborative Life Sciences Building (CLSB)
Mail Code: CL3G
2730 SW Moody Avenue, Portland, OR 97201

Education
M.A., University of Missouri, Columbia
Ph.D., University of Illinois, Urbana-Champaign
Post Doctoral Fellow, INRA Versailles, France
Post Doctoral Fellow, University of California, Berkeley

Research Area
OHSU Center for Spatial Systems Biomedicine

Research Interests
My research has focused on exploration of the mechanisms by which genomic, transcriptional and proteomic abnormalities occur in selected cancers, and the elucidation of how these abnormalities contribute to cancer pathophysiologies and influence response to gene targeted therapies.

Selected Publications

  • Heiser, L.M., Sadanandam, A., Kuo, W.L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Wooster, R.F., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc. Natl. Acad. Sci. USA. 109(8):2724-2729. PMC3286973.
  • Collisson, E.A., Sadanandam, A., Olson, P., Gibb, W.J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G.E., Jakkula, L., Feiler, H.S., Ko, A.H., Olshen, A.B., Danenberg, K.L., Tempero, M.A., Spellman, P.T., Hanahan, D., Gray, J.W. (2011) Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Med. 17:500-503. PMC278279.
  • Lapuk, A., Marr, H., Jakkula, L., Pedro, H., Bhattacharya, S., Purdom, E., Hu, Z., Simpson, K., Pachter, L., Durinck, S., Wang, N., Parvin, B., Fontenay, G., Speed, T., Garbe, J., Stampfer, M., Bayandorian, H., Dorton, S., Clark, T.A., Schweitzer, A., Wyrobek, A., Feiler, H., Spellman, P., Conboy, J., Gray, J.W. (2010) Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol. Cancer Res., 8(7): 961-74. PMC2911965.
  • Verhaak, R.G., Hoadley, K.A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M.D., Miller, C.R., Ding, L., Golub, T., Mesirov, J.P., Alexe, G., Lawrence, M., O'Kelly, M., Tamayo, P., Weir, B.A., Gabriel S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H.S., Hodgson, J.G., James, C.D., Sarkaria, J.N., Brennan, C., Kahn, A., Spellman, P.T., Wilson, R.K., Speed, T.P., Gray, J.W., Meyerson, M., Getz, G., Perou, C.M., Hayes, D.N. (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell, 17(1):98-110. PMC2818769.
  • Purcell, J.W., Davis, J., Reddy, M., Martin, S., Samayoa, K., Vo, H., Thomsen, K., Bean, P., Kuo, W.-L., Ziyad, S., Billig, J., Feiler, H.S., Gray, J.W., Wood, K.W., Cases, S. (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin. Cancer Res., 16(2):566-76. PMC2844774.