BME Seminar w/ Dr. Joseph J. Shatzel
03/09/18 Portland, Ore.
Engineering solutions to the unmet needs in clinical hematology; Preventing post thrombotic syndrome and beyond
Speaker: Joseph J. Shatzel, MD
Knight Cancer Institute
Oregon Health &Science University
Time: Friday, March 9, 2018
Location: Center for Health and Healing, Third Floor, Conference Room 4
3303 S.W. Bond Ave.
Portland, OR 97239
Abstract: Deep vein thrombosis (DVT) is common, affecting 1 out of every 1000 people annually in America. Approximately 30% of patients will develop chronic symptoms after a DVT secondary to irreversible venous damage, including chronic edema, pain, and debilitating leg ulcers. There are currently no validated preventative interventions to avert these chronic symptoms, coined "post thrombotic syndrome," other than anticoagulation, with recent trials of catheter directed interventions failing to find a benefit. Likewise, once post thrombotic syndrome develops there are no effective treatments to mitigate the symptoms. In this talk we will discuss the pathophysiology of post thrombotic syndrome including the roles of acute venous damage, venous obstruction, and the inflammatory process of thrombosis resolution that leads to permanent venous damage. We will overview current in vivo models of post thrombotic syndrome, and discuss potential targeted therapies to prevent post thrombotic syndrome including multi-tyrosine kinase inhibitors and drugs targeting the intrinsic pathway of coagulation. Lastly, we will discuss methods to clinically trial such interventions in patients with high risk DVTs.