Become a member of a vibrant research team under supervision of Principal Investigator Dr. Joe Gray, an internationally renowned cancer and genomic scientist in the Biomedical Engineering Department and the Knight Cancer Institute. Participate in design and execution of imaging based techniques to identify changes in cellular signaling networks that accompany cancer progression and drug resistance. Participate in research efforts focusing on the design of immunohistochemical and electron microscopy (EM) based techniques for integrated light and electron microscopy imaging, and application of these imaging protocols to analysis of clinical samples.
Job Posting ID: IRC38675 (www.ohsujobs.com)
Assistant Professor / Associate Professor / Professor
Applicants are sought with interests in the basic molecular or cellular biosciences, and who could take a leadership role in the development of the newly established OHSU/FEI Living Lab, including a Titan Krios transmission cryo-electron microscope (TEM), a Helios NanoLab DualBeam microscope, an integrated electron and light microscope (Tecnai with iCorr) and a super resolution fluorescence microscopy (http://tinyurl.com/cl2va5w). The recruitment will be to the Center for Spatial Systems Biomedicine (http://www.ohsu.edu/ocssb) with an academic appointment in Biomedical Engineering and/or other basic science departments. This notice is in addition to the previously announced similar opening in the Department of Biochemistry & Molecular Biology (IRC37050). In both cases, the successful applicant will be expected to develop an independent, extramurally-funded basic science research program, and to contribute to research training programs as well as medical education. Preference will be given to candidates with experience in the application of electron microscopy to problems in cell biology. The appointment can be at the Assistant, Associate or Full Professor level, so junior, mid-level and senior candidates are encouraged to apply.
Job Posting ID: IRC33199 (www.ohsujobs.com)
Senior Research Assistant Position (Gray Lab)
Become a member of a vibrant research team under supervision of Principal Investigator Dr. Joe Gray, an internationally renowned cancer and genomic scientist in the Biomedical Engineering Department and the Knight Cancer Institute. Apply advanced imaging based high-throughput RNAi and small molecule analyses to identify changes in cellular signaling networks that accompany cancer progression and drug resistance. Participate in broader research efforts, including continued development of the cell microarray based techniques, cytochemical assay development for imaging cytometry based analyses and application of these cytochemical assays to analyses of clinical samples to dissect pathways regulating cancer progression and drug sensitivity.
Job Posting ID: IRC38596 (www.ohsujobs.com)
Post-Doc and Ph.D. Student Positions (Biomedical Signals and Systems Lab)
The Biomedical Engineering Department at Oregon Health & Science University is seeking one Ph.D. student and one postdoctoral researcher. The successful candidate will have a Ph.D. degree (for the postdoc position) or a Masters degree (for the Ph.D. student position) and experience in or more of the following areas:
- In-home technology development and big-data analytics
- Hearing science
- Medical device development
- Machine learning, pattern recognition, signal processing, statistical techniques
There are currently several funded projects to work on within this lab which span several areas within the broad field of biomedical engineering and include the following specific topic areas:
- Research on in-home health technologies and big-data analytics. We are developing a system that tracks mobility, location, and other movement metrics of a person within their living environment (home or assisted care facility) and attempts to infer cognitive and physical characteristics from these mobility metrics. The system includes both a body-worn tag and also incorporates a tag-free method for monitoring movement of the resident. We are currently developing machine learning tracking and classification algorithms for determining position of the resident within the home as well as activities of daily living. We are members of the Oregon Center for Aging and Technology (ORCATECH) www.orcatech.org, and the system is currently being deployed within the ORCATECH Living Labs, which are homes of older adults living within the community that have agreed to have their homes out-fit with various sensing technologies.
- Research on hearing science – hearing aids, otoacoustic emissions, and evoked responses. We are developing new signal processing algorithms that utilize face motion (mouth and lips) for improving voice activity detection (VAD). We are currently looking at using otoacoustic emissions and other hearing metrics to assess ototoxicity damage in people receiving cancer therapy. We have used otoacoustic emissions and the medial olivocochlear reflex to predict acute blood sugar changes in people with diabetes. Future projects may include using new technologies in brain-computer interfaces (BCI) to better assist people with sensory impairment. We are a member of the National Center for Rehabilitative Auditory Research (NCRAR) within the Portland VA Medical Center and much of our auditory research is done in collaboration with NCRAR.
- Research on diabetes algorithm and device development. We are currently designing and building a fully automated artificial pancreas system that includes multiple glucose sensors and multiple hormone delivery pumps (insulin and glucagon) along with a control algorithm. The work is done in collaboration with the OHSU Department of Endocrinology. The current system being evaluated on hospital wards was designed using off-the-shelf components and a custom control algorithm. Future work is focused on building a solid-state sensor-catheter to investigate integrating glucose sensing elements with the delivery catheter. This work is being done in collaboration with chemistry and microfabrication labs at Oregon State University.
The successful candidate may have a broad background to work across multiple disciplines in these topic areas or alternatively, be more interested in focusing in on one of these specific areas. The successful candidate will have sufficient skills to develop data acquisition systems (hardware and software development skills required) and knowledge about algorithm development including biomedical signal processing and machine learning to contribute within the lab. Specifically, the successful candidate should have excellent skills in Matlab and other programming languages such as C/C++/C#/Java.
Strong English language skills (writing and speaking) are required.
Within the lab, you will gain experience publishing papers, writing grant proposals, giving presentations at technical meetings, and working with partners in both industry and university / government. The post-doc candidate should have a prior record of publications.
Both positions are open immediately. The Ph.D. student position is open-ended (with a minimum of 3 years) and the post-doctoral position is for two years with competitive salary and compensation.
Cardiovascular Development (Rugonyi Lab)
The laboratory of Dr. Sandra Rugonyi hasa postdoctoral fellow opening to work on projects related to cardiovascular development.
Candidates considered for this position must have:
i) strong background in mechanics and cardiovascular principles (flow, pressure, tissue strains/stresses);
ii) lab hands-on experience in imaging, measuring blood flows and/or blood pressures (experience manipulating embryos or small organisms is a plus);
iii) strong data analysis skills; and iv) intellectual curiosity. PhD in a relevant field is required. Candidates must also have a demonstrated ability for independent research, strong written and oral communication skills, and the ability to work as part of a collaborative team. Experience in cardiovascular mechanics is not required but it is preferred, however, a strong desire to perform advanced research in cardiovascular development is a must.
Job Posting ID: IRC36791 (www.ohsujobs.com)
Postdoctoral Fellow Position (Gibbs Lab)
Super-Resolution Imaging Microscopy
The Center for Spatial Systems Biomedicine and Department of Biomedical Engineering at OHSU has an open postdoctoral fellow position in the laboratory of Dr. Summer Gibbs to develop super resolution, quantitative imaging microscopy for visualizing intracellular processes signaling at the nanoscopic level.
The successful applicant will develop libraries of photoswitchable fluorophores enabling multi-spectral super resolution microscopy based on single molecule localization technology. The applicant will be responsible for the following research areas:
- Synthesis of libraries of photoswitchable fluorophores optimized for single molecule localization microscopy
- Intracellular protein tagging with newly developed fluorophores
- Optimization of sample preparation for super resolution imaging
- Multi-spectral super resolution microscopy imaging of intracellular processes in collaboration with Dr. Xiaolin Nan’s research group
Numerous opportunities are available for application of the developed technology to both fundamental and clinically-direct projects in the areas of spatial systems biology/biomedicine and in the areas of cancer and neurological disease. This position will involve interaction in team-collaborative projects composed of biologists and clinicians, physicists, and industrial partners.
How to Apply:
Applicants should submit a letter of application, curriculum vitae, and three letters of reference using the on-line system via the OHSU Human Resources website (see position listing IRC36791 at www.ohsujobs.com).
Visit our website at www.ohsu.edu/ocssb.
- Recent (within last 2 years) Ph.D. degree in synthetic chemistry/biomedical engineering/chemical engineering or related field
- Expertise in synthetic chemistry/microscopy/imaging
- Excellent verbal and written communication skills
- Proven ability to organize research results for publication and presentations
(Senior Research Assistant)
The Center for Spatial Systems Biomedicine and Department of Biomedical Engineering at OHSU have an open postdoctoral fellow position under the supervision of Dr. Laura Heiser. The successful applicant will be part of a research group focused on integrating 'omics' approaches to research cancer biology. Work in the group is interdisciplinary and highly collaborative. Key responsibilities include analysis of RNAseq data to identify genes of interest; maintaining Postgresql database of drug response data; managing high throughput profiling data; running standard analysis pipeline for drug response data; responding to data access requests from other lab members, assisting PI with grant and manuscript preparation and submission; maintaining an accurate and detailed records of all work and preparing results for publication in scientific journals and presentations at seminars.
Job Posting ID: IRC37756 (www.ohsujobs.com)
Postdoctoral Position (Yantasee Lab)
Pre-Clinical Nanoparticle Cancer Therapeutics
The Yantasee Lab in the Department of Biomedical Engineering at OHSU has an open postdoctoral fellow position in a pre-clinical therapeutics laboratory that focuses on nanoparticle delivery of siRNA and drugs for the treatment of breast and prostate cancer. The successful candidate will contribute to one or more of the following activities; nanomaterial synthesis and characterization, efficacy and safety studies of the nanomaterials both in cultured cells and cancer mouse models. The overall goal is to develop new drugs that will overcome resistance to the gold standard therapies of cancer as a result of gene overexpression.
Applicants should possess a recently earned MS or PhD degree(s) in one or more of the following areas: tumor/molecular cell biology, experimental therapeutics, and synthetic chemistry specific to polymeric-inorganic nanomaterials. Experience in animal handling, cancer mouse models, imaging techniques, and cell-based assays is preferred.
OHSU Center for Spatial Systems Biomedicine
Additional positions may be available with the OHSU Center for Spatial Systems Biomedicine.
OHSU is an Affirmative Action, Equal Opportunity Employer. Women, minorities, disabled persons, Vietnam era and disabled veterans are encouraged to apply. OHSU is a smoke-free workplace.
Contact Janet Itami