Abdominal Aortic Aneurysms (AAA)
An abdominal aortic aneurysm (AAA) is a pathological dilation of the abdominal aorta, which carries a high mortality rate if ruptured. The most commonly used surrogate marker of rupture risk is the maximal transverse diameter of the aneurysm. More recent studies suggest that wall stress from models of patient-specific aneurysm geometries extracted, for instance, from computed tomography images may be a more accurate predictor of rupture risk and an important factor in AAA size progression. However, quantification of wall stress is typically computationally intensive and time-consuming, mainly due to the nonlinear mechanical behavior of the abdominal aortic aneurysm walls. Further, by analyzing only maximal transverse diameter behavior we might be missing important information about the AAA progression.
The Rugonyi lab is currently developing approaches to facilitate computation of patient-specific wall stresses and to follow AAA progression over time.