Research

Jacobs Lab Research Overview

The Jacobs Lab is developing new technologies in the fields of diabetes, telehealth, and hearing science:

  • Closed loop artificial pancreas research and development
  • Ubiquitous computing in the home
  • Hearing research

These projects also interrelate in various ways. For example, we are studying how ubiquitous sensing using body-worn sensors can be used to predict and grade exercise in people with type 1 diabetes so as to adjust their insulin and glucagon dosing within the context of a closed loop artificial pancreas system (Mitigating Risk project). As another example of projects cross-relating, in addition to designing systems that assess hearing within a test facility, we create systems that can be used by patients within the home environment or by clinicians within a hospital ward (Comprehensive Ototoxicity Monitoring Program for VA project).

Ubiquitous Computing (map of living quarters with monitoring/tracking device technology), Artificial Pancreas diagram, hearing science subject wearing headphone and using a computer tablet to give feedback responses.

(Left to Right:) Ubiquitous Computing in the home; Bi-Hormonal Artificial Pancreas; Hearing Science Research

Ongoing Research Projects

Mitigating risk in a closed loop system by exercise detection and miniaturization

Grant: 1DP3DK101044-01
Program: NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Principal Investigators: Peter Jacobs, Jessica R. Castle
Project Start and End Dates: September 30, 2013 to September 29, 2017APC System developed by the Peter Jacobs Lab

Project Summary: The objective of this project is to improve treatments for type 1 diabetes via optimization of a closed loop artificial pancreas system by 1) incorporating exercise detection to reduce the risk of hypoglycemia and 2) improving usability by reducing the number of system components.

Components of the bi-hormonal artificial pancreas system: Two Tandem pumps, a Dexcom glucose sensor, and a Nexus smart phone running our control algorithm.

Unobtrusive measurement of sleep disordered breathing in the home

Sleep Monitor

Grant: 2R01HL098621-04A1
Program: NIH National Heart, Blood and Lung Institute (NHLBI)
Principal Investigators: Chad Hagen, Peter Jacobs
Project Start and End Dates: January 1, 2014 to December 31, 2016

Project Summary: The purpose of this project is to use load cells to assess sleep apnea and other sleep disorders passively. Load cell developed to detect respiration and sleep apnea. This sensor gets placed on the rail of a bed frame. We use signal processing and machine learning to translate the sensed signal into an estimation of disordered breathing.

A Passive Tag-Free Approach to Localization and Activity Monitoring

Grant: ETAC-12-239042
Program: Alzheimer's Association 2012 Everyday Technologies for Alzheimer's Care
Principal Investigators: Eric Wan, Peter Jacobs
Project Start and End Dates
: November 1, 2012 to October 1, 2014

Grant:  1R43AG049573 –01A1 (Jacobs, Wan)                                            

Program: NIH/NIA National Institute for aging                   

Principal investigator: Peter Jacobs

Project start and End DatesSept 1 2010 – May 31, 2016

Co-investigator: Michelle Cameron                                                              

Project summary: In-home monitoring system for assessing gait using wall-mounted Radio Frequency transceivers. The objective of this project is to develop new ways of assessing gait using Radio Frequency fingerprinting and RSSI signals.


Project Summary: The objective of this grant is to research and develop a Position Tracking and Mobility Assessment System targeted specifically for monitoring patients with mild cognitive impairment / Alzheimer’s Disease within their home environment.

Comprehensive Ototoxicity Monitoring Program for VA: A Randomized Trial

Ototoxicity project

Grant: RX000239
Program: VA Rehabilitation Research and Development Merit Award
Principal Investigators: Marilyn Dille, Dawn Konrad-Martin
Project Start and End Dates: April 1, 2014 to March 31, 2018
Co-Investigator: Peter Jacobs

Project Summary: The proposed study is designed to establish that ototoxicity monitoring when introduced as a comprehensive program of evidence-based protocols will improve Veteran hearing outcomes and quality of life by influencing therapeutic planning and improving access to timely audiological rehabilitation services.

Position Tracking and Mobility Assessment System for Indoor Monitoring of Elders

Grant: 2R42AG035400-02A1
Program: NIH Small Business Technology Transfer (STTR)
Principal Investigator: Eric A. Wan
Co-investigator: Peter Jacobs
Project Start and End DatesSept 1 2010 – May 31, 2016

Project Summary: This phase-2 STTR will commercialize a Position Tracking and Mobility Assessment System targeted specifically for elderly patients within their home environment.

Three images of EmbedRF technology pieces.

Above: EmbedRF body-worn tag which includes a time-of-flight radio transceiver (TOF), an inertial measurement unit (IMU) with 3-axis accelerometer, 3-axis gyroscope. Wall-mounted access point shown on the right, which gets placed within the home to remotely assess mobility of a patient.

Mobile Monitoring of Chemotherapy-induced peripheral neuropathy

Mobile Monitoring of Chemotherapy

Program: OHSU Pilot Project
Principal Investigator: Kerri M. Winters-Stone
Co-investigator: Peter Jacobs
Project Start and End DatesSept 1, 2014-Aug 30 2016

 Project Summary: We are developing a mobile phone-based system that could accurately quantify chemotherapy-induced peripheral neuropathy symptoms and functional changes using a smartphone application interface that is easy to administer by a clinician or a non-expert such as by a patient herself and which could be broadly implemented in multiple settings and populations. For the proposed study we want to determine the feasibility and acceptability of the mobile phone system by clinicians, nurses, physical therapists and patients. The feasibility and acceptability data will be used to refine the user interface, data collection protocols, signal processing during a neuropathy test, balance and sway test, and walking test and other preferences and features of the system to maximize utilization potential in the clinic and home settings. We expect that following this feasibility study the system will be ready for near-term, widespread implementation.

Comprehensive Fall Prevention and Detection in MS

Grant: 1l01RX001831-01A1 (Cameron)                                                     

Program: VA RR&D VA Rehabilitation Research and Development Merit Award                

Principal Investigator: Michelle Cameron           

Project start and end datesJanuary 1 2016 – December 31 2020

Co-investigator: Peter Jacobs

Project Summary: The objective of this grant is to develop and evaluate a fall detection and localization system that my research team is currently developing. The evaluation will take place within a cohort of patients with MS who fall often.

 

iPancreas: Internet based on-demand artificial pancreas app-generator to accelerate clinical trials research

Grant:2017 Catalyst Award (Jacobs),

Program: OHSU OCTRI Pilot Award

Principal investigator, Peter G. Jacobs

Project start and end dates:July 1st 2016 – June 30th, 2017. Project summary:  iPancreas: Internet based on-demand artificial pancreas app-generator to accelerate clinical trials research

Project summary:The objective of this project is to translate the OHSU artificial pancreas (AP) technology for use by other research groups through the creation of iPancreas, an Internet-based on-demand AP app generator.


Non-aqueous glucagon formulation to enable outpatient studies with a bi-hormonal pump

Grant:Juvenile Diabetes Research Foundation, Discovery & Development Partnership

Program: JDRF

Principal investigatorCastle, Jacobs, Petrelski

Project start and end dates:January 1st 2016 – December 31, 2017. Project summary:  iPancreas: Internet based on-demand artificial pancreas app-generator to accelerate clinical trials research

Project summary:The goal of this project is to test a bi-hormonal closed-loop system utilizing two omnipods, one to deliver aspart insulin and one to deliver stabilized glucagon (formulated by Xeris) as compared to an insulin alone closed-loop system and as compared to standard of care (sensor-augmented pump) in the outpatient setting.